{"id":"https://openalex.org/W2520631810","doi":"https://doi.org/10.1109/embc.2016.7591481","title":"Estimation of second-phase insulin secretion in the Zucker fatty rat","display_name":"Estimation of second-phase insulin secretion in the Zucker fatty rat","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2520631810","doi":"https://doi.org/10.1109/embc.2016.7591481","mag":"2520631810","pmid":"https://pubmed.ncbi.nlm.nih.gov/28324988"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591481","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591481","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017957196","display_name":"Micaela Morettini","orcid":"https://orcid.org/0000-0002-8327-8379"},"institutions":[{"id":"https://openalex.org/I210167222","display_name":"Foro Italico University of Rome","ror":"https://ror.org/03j4zvd18","country_code":"IT","type":"education","lineage":["https://openalex.org/I210167222"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Micaela Morettini","raw_affiliation_strings":["Department of Information Engineering, University of Rome \u201cForo Italico\u201d, Rome, Italy","Department of Information Engineering, University of Rome \"Foro Italico\", Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, University of Rome \u201cForo Italico\u201d, Rome, Italy","institution_ids":["https://openalex.org/I210167222"]},{"raw_affiliation_string":"Department of Information Engineering, University of Rome \"Foro Italico\", Rome, Italy","institution_ids":["https://openalex.org/I210167222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039811734","display_name":"Francesco Di Nardo","orcid":"https://orcid.org/0000-0002-5362-3776"},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Di Nardo","raw_affiliation_strings":["Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047369575","display_name":"Carla Cogo","orcid":null},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla E. Cogo","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007049139","display_name":"Emanuela Faelli","orcid":"https://orcid.org/0000-0002-9093-8021"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Faelli","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064947412","display_name":"Sandro Fioretti","orcid":"https://orcid.org/0000-0002-7783-3065"},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sandro Fioretti","raw_affiliation_strings":["Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091455235","display_name":"Laura Burattini","orcid":"https://orcid.org/0000-0002-9474-7046"},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Burattini","raw_affiliation_strings":["Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Information Engineering, Universit\u00e0 Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068590188","display_name":"Piero Ruggeri","orcid":"https://orcid.org/0000-0001-5939-1489"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Ruggeri","raw_affiliation_strings":["Department of Experimental Medicine, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":null,"first_page":"3494","last_page":"3497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.6767803430557251},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.670903742313385},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.6591472029685974},{"id":"https://openalex.org/keywords/correlation-coefficient","display_name":"Correlation coefficient","score":0.49987316131591797},{"id":"https://openalex.org/keywords/secretion","display_name":"Secretion","score":0.46764111518859863},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.4194403290748596},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4001638889312744},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3800670802593231},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.12248721718788147},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.07342267036437988}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6767803430557251},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.670903742313385},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6591472029685974},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.49987316131591797},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.46764111518859863},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4194403290748596},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4001638889312744},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3800670802593231},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.12248721718788147},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07342267036437988}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002096","descriptor_name":"C-Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005951","descriptor_name":"Glucose Tolerance Test","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2016.7591481","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591481","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28324988","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28324988","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:iris.univpm.it:11566/245028","is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/245028","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","score":0.8299999833106995,"display_name":"Zero hunger"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W44668478","https://openalex.org/W1586058223","https://openalex.org/W1916626870","https://openalex.org/W1989171776","https://openalex.org/W1990945706","https://openalex.org/W2009918956","https://openalex.org/W2011571924","https://openalex.org/W2026118624","https://openalex.org/W2037211078","https://openalex.org/W2043869817","https://openalex.org/W2048491320","https://openalex.org/W2077149049","https://openalex.org/W2091452791","https://openalex.org/W2101766292","https://openalex.org/W2103358437","https://openalex.org/W2105955034","https://openalex.org/W2115804516","https://openalex.org/W2117647378","https://openalex.org/W2122138196","https://openalex.org/W2135217219","https://openalex.org/W2137174239","https://openalex.org/W2137473529","https://openalex.org/W2149413499","https://openalex.org/W2152703443","https://openalex.org/W2169578859","https://openalex.org/W2936189053","https://openalex.org/W3144259829","https://openalex.org/W4231043992","https://openalex.org/W4239044368","https://openalex.org/W6601835136","https://openalex.org/W6680151119"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2065284647","https://openalex.org/W2152471247","https://openalex.org/W2164386116","https://openalex.org/W2475128168","https://openalex.org/W1900806339","https://openalex.org/W2146278644","https://openalex.org/W2112178421","https://openalex.org/W2137121488","https://openalex.org/W1979139803"],"abstract_inverted_index":{"The":[0,55],"purpose":[1],"of":[2,11,22,41,57,165,174,180,204],"the":[3,9,12,20,27,36,39,63,145,156,172,175,188,191,205],"present":[4],"study":[5,189],"was":[6,60],"to":[7,148,161],"test":[8],"efficacy":[10],"empiric":[13],"index":[14,32,59,67,109,158,196],"SPIR":[15,31,86,108,138,157],"(Second-phase":[16],"Insulin":[17],"Release)":[18],"in":[19,26,94,144,171,183,209],"quantification":[21,203],"second-phase":[23,64,176,206],"insulin":[24,42,177,207],"secretion":[25,178,208],"Zucker":[28,96,104,184],"Fatty":[29,185],"Rat.":[30],"is":[33,159],"defined":[34],"as":[35,193],"area":[37],"under":[38],"curve":[40],"between":[43],"8":[44],"and":[45,85,101,137,179,201],"90":[46],"min":[47],"after":[48],"an":[49],"Intravenous":[50],"Glucose":[51],"Tolerance":[52],"Test":[53],"(IVGTT).":[54],"validation":[56],"such":[58],"performed":[61],"against":[62],"\u03b2-cell":[65],"responsiveness":[66],"(\u03a6":[68],"<sub":[69,82,117,133,167],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[70,83,118,134,168],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sub>":[71,84,119,135,169],")":[72],"provided":[73],"by":[74],"C-peptide":[75],"minimal":[76],"model.":[77],"To":[78],"this":[79],"aim,":[80],"\u03a6":[81,116,132,166],"were":[87],"simultaneously":[88],"computed":[89],"from":[90],"IVGTT":[91],"data,":[92],"measured":[93],"six":[95],"fatty":[97],"rats":[98,106],"(ZFR),":[99],"7-to-9week-old,":[100],"seven":[102],"age-matched":[103],"lean":[105],"(ZLR).":[107,151],"showed":[110,140],"a":[111,141,194,198],"significant":[112,142],"linear":[113],"correlation":[114,121],"with":[115],"(Pearson's":[120],"coefficient,":[122],"r":[123],"=":[124,127],"0.91,":[125],"R-square":[126],"0.82,":[128],"P<;0.001).":[129],"Moreover,":[130],"both":[131],"(P<;0.001)":[136,139],"increase,":[143],"ZFRs,":[146],"compared":[147],"control":[149],"group":[150],"These":[152],"findings":[153],"suggest":[154],"that":[155],"able":[160],"provide":[162],"similar":[163],"information":[164],",":[170],"evaluation":[173],"its":[181],"alteration":[182],"Rats.":[186],"Thus,":[187],"proposes":[190],"SPIR,":[192],"suitable":[195],"for":[197],"simple,":[199],"reliable":[200],"low-cost":[202],"ZFR.":[210]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}