{"id":"https://openalex.org/W2533113097","doi":"https://doi.org/10.1109/embc.2016.7591378","title":"Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions","display_name":"Unsupervised selection of RV144 HIV vaccine-induced antibody features correlated to natural killer cell-mediated cytotoxic reactions","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2533113097","doi":"https://doi.org/10.1109/embc.2016.7591378","mag":"2533113097","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268960"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591378","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591378","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023779408","display_name":"Ferdi Sarac","orcid":"https://orcid.org/0000-0002-7080-1634"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ferdi Sarac","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037936080","display_name":"Volkan Uslan","orcid":"https://orcid.org/0000-0001-6252-8853"},"institutions":[{"id":"https://openalex.org/I3129561438","display_name":"Mevlana University","ror":"https://ror.org/00zv6rh96","country_code":"TR","type":"education","lineage":["https://openalex.org/I3129561438"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Volkan Uslan","raw_affiliation_strings":["Bio-Health Informatics Research Group, Mevlana University, Selcuklu, Konya, Turkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bio-Health Informatics Research Group, Mevlana University, Selcuklu, Konya, Turkiye","institution_ids":["https://openalex.org/I3129561438"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057405456","display_name":"H\u00fcseyin \u015eeker","orcid":"https://orcid.org/0000-0002-1255-9552"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Huseyin Seker","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033623398","display_name":"Ahmed Bouridane","orcid":"https://orcid.org/0000-0002-1474-2772"},"institutions":[{"id":"https://openalex.org/I32394136","display_name":"Northumbria University","ror":"https://ror.org/049e6bc10","country_code":"GB","type":"education","lineage":["https://openalex.org/I32394136"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmed Bouridane","raw_affiliation_strings":["Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Engineering and Environment, The University of Northumbria at Newcastle, Newcastle-upon-Tyne, The United Kingdom","institution_ids":["https://openalex.org/I32394136"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6965,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74921113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"9","issue":null,"first_page":"3072","last_page":"3075"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5834226012229919},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5728245377540588},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.5726366639137268},{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.5535090565681458},{"id":"https://openalex.org/keywords/hiv-vaccine","display_name":"HIV vaccine","score":0.5366472601890564},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5130764245986938},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.42111122608184814},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.41842931509017944},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3926717936992645},{"id":"https://openalex.org/keywords/vaccine-trial","display_name":"Vaccine trial","score":0.3729330897331238},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.338247686624527},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.24675911664962769},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17795869708061218},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.10263639688491821}],"concepts":[{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5834226012229919},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5728245377540588},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5726366639137268},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5535090565681458},{"id":"https://openalex.org/C2780195530","wikidata":"https://www.wikidata.org/wiki/Q1479804","display_name":"HIV vaccine","level":4,"score":0.5366472601890564},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5130764245986938},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42111122608184814},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.41842931509017944},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3926717936992645},{"id":"https://openalex.org/C2778190748","wikidata":"https://www.wikidata.org/wiki/Q7907956","display_name":"Vaccine trial","level":3,"score":0.3729330897331238},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.338247686624527},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.24675911664962769},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17795869708061218},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.10263639688491821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069558","descriptor_name":"Unsupervised Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007694","descriptor_name":"Killer Cells, Natural","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015699","descriptor_name":"HIV Envelope Protein gp120","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016915","descriptor_name":"AIDS Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2016.7591378","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591378","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268960","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:nrl.northumbria.ac.uk:29518","is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/29518/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Book Section"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","score":0.6700000166893005,"id":"https://metadata.un.org/sdg/10"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1570713908","https://openalex.org/W1966607693","https://openalex.org/W1976344112","https://openalex.org/W2014801508","https://openalex.org/W2040015143","https://openalex.org/W2052200679","https://openalex.org/W2057961805","https://openalex.org/W2084376194","https://openalex.org/W2128873747","https://openalex.org/W2133462743","https://openalex.org/W2137226992","https://openalex.org/W2143857397","https://openalex.org/W2149298154","https://openalex.org/W2149620660","https://openalex.org/W2152048324","https://openalex.org/W2152640863","https://openalex.org/W2153635508","https://openalex.org/W2158933803","https://openalex.org/W2160358721","https://openalex.org/W2256782633","https://openalex.org/W2264003125","https://openalex.org/W2293981868","https://openalex.org/W2319347498","https://openalex.org/W6660318337","https://openalex.org/W6681822384"],"related_works":["https://openalex.org/W3142450751","https://openalex.org/W2966479367","https://openalex.org/W2330692954","https://openalex.org/W2944090095","https://openalex.org/W3117318727","https://openalex.org/W4297780793","https://openalex.org/W3125943952","https://openalex.org/W2020357104","https://openalex.org/W2986505809","https://openalex.org/W3016404901"],"abstract_inverted_index":{"HIV-1":[0,33],"vaccine":[1,76,92,114],"injection":[2],"has":[3,120],"been":[4],"shown":[5],"less":[6],"effective":[7,30],"due":[8],"to":[9,47,58,79,129,149,170],"the":[10,15,18,37,60,81,105,113,151,163],"diversity":[11],"of":[12,17,39,53,62,102,110,126],"antigens.":[13],"Increasing":[14],"knowledge":[16],"associations":[19],"between":[20,84,173],"immune":[21,85],"system":[22,86],"and":[23,66,78,87,108,132,181,198,206],"virus":[24],"would":[25],"ultimately":[26],"result":[27],"in":[28,99,147],"producing":[29],"vaccines":[31],"against":[32],"virus.":[34,89],"To":[35],"increase":[36],"understanding":[38],"immunological":[40],"information,":[41],"computational":[42],"models":[43],"can":[44],"be":[45],"utilised":[46,146,169],"construct":[48],"predictive":[49,209],"models.":[50],"The":[51,90,188],"aim":[52],"this":[54,136],"study":[55],"is,":[56],"therefore,":[57],"predict":[59],"effect":[61],"antibody":[63,122,153],"features":[64,123,127,154],"(IgGs)":[65],"primary":[67],"Natural":[68,177],"Killing":[69],"(NK)":[70,179],"cells'":[71],"cytotoxic":[72],"activities":[73],"on":[74],"RV144":[75,91],"recipients":[77],"disclose":[80],"functional":[82],"relationship":[83],"HIV":[88],"data":[93,97,118],"set":[94],"contains":[95],"100":[96],"samples":[98,107],"which":[100],"20":[101],"them":[103,111],"are":[104,112,145,157,168],"placebo":[106],"80":[109],"injected":[115],"samples.":[116],"Each":[117],"sample":[119],"twenty":[121],"that":[124,183],"consist":[125],"related":[128],"IgG":[130],"subclass":[131],"antigen":[133],"specificity.":[134],"In":[135],"paper,":[137],"five":[138],"different":[139],"unsupervised":[140],"feature":[141],"selection":[142],"methods":[143,167],"(USFSMs)":[144],"order":[148],"identify":[150],"discriminating":[152],"as":[155,159,194,196],"USFSMs":[156],"regarded":[158],"unbiased":[160],"approach.":[161],"Then,":[162],"support":[164,202],"vector":[165,203],"based":[166],"assess":[171],"association":[172],"cellular":[174],"cytotoxicity":[175],"by":[176],"Killer":[178],"cells":[180,182],"release":[184],"glycoprotein":[185],"(gp)120":[186],"antibody.":[187],"results":[189],"yield":[190],"high":[191],"correlation":[192],"coefficient":[193],"much":[195],"0.48":[197],"0.65":[199],"for":[200],"classificationthe":[201],"regression":[204],"(SVR)":[205],"classification":[207],"(SVM)":[208],"models,":[210],"respectively.":[211]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
