{"id":"https://openalex.org/W2536030005","doi":"https://doi.org/10.1109/embc.2016.7591310","title":"A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization","display_name":"A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2536030005","doi":"https://doi.org/10.1109/embc.2016.7591310","mag":"2536030005","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268898"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591310","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591310","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016565833","display_name":"Clayton S. Bingham","orcid":"https://orcid.org/0000-0001-5850-1308"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Clayton S. Bingham","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052774849","display_name":"Kyle Loizos","orcid":"https://orcid.org/0000-0002-1461-0489"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle Loizos","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044622241","display_name":"Gene J. Yu","orcid":"https://orcid.org/0000-0002-8154-4119"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gene Yu","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019810821","display_name":"Andrew Gilbert","orcid":"https://orcid.org/0000-0001-5758-1756"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Gilbert","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047655773","display_name":"Jean\u2010Marie C. Bouteiller","orcid":"https://orcid.org/0000-0003-3069-0826"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Marie Bouteiller","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070732235","display_name":"Dong Song","orcid":"https://orcid.org/0000-0002-6179-1120"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Song","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044898858","display_name":"Gianluca Lazzi","orcid":"https://orcid.org/0000-0002-6365-7283"},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianluca Lazzi","raw_affiliation_strings":["Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911478","display_name":"Theodore W. Berger","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore W. Berger","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5016565833"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.4868,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64588794,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2016","issue":null,"first_page":"2794","last_page":"2797"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6401506662368774},{"id":"https://openalex.org/keywords/emulation","display_name":"Emulation","score":0.5492602586746216},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.5016710758209229},{"id":"https://openalex.org/keywords/neural-prosthesis","display_name":"Neural Prosthesis","score":0.49499768018722534},{"id":"https://openalex.org/keywords/perforant-path","display_name":"Perforant path","score":0.4690288305282593},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"Dentate gyrus","score":0.40228503942489624},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.356328547000885},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3396182060241699},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.30325788259506226},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.27022701501846313},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.22316384315490723},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.21898499131202698},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15615642070770264}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6401506662368774},{"id":"https://openalex.org/C149810388","wikidata":"https://www.wikidata.org/wiki/Q5374873","display_name":"Emulation","level":2,"score":0.5492602586746216},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5016710758209229},{"id":"https://openalex.org/C2908765479","wikidata":"https://www.wikidata.org/wiki/Q1431093","display_name":"Neural Prosthesis","level":2,"score":0.49499768018722534},{"id":"https://openalex.org/C2776168963","wikidata":"https://www.wikidata.org/wiki/Q7168164","display_name":"Perforant path","level":4,"score":0.4690288305282593},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.40228503942489624},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.356328547000885},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3396182060241699},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.30325788259506226},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.27022701501846313},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.22316384315490723},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.21898499131202698},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15615642070770264},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004566","descriptor_name":"Electrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018891","descriptor_name":"Dentate Gyrus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019580","descriptor_name":"Perforant Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019580","descriptor_name":"Perforant Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019580","descriptor_name":"Perforant Pathway","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7591310","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591310","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268898","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268898","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1850752598","https://openalex.org/W1989345995","https://openalex.org/W2058871194","https://openalex.org/W2116671604","https://openalex.org/W2117120818","https://openalex.org/W2154174049","https://openalex.org/W2161659486","https://openalex.org/W2202145822","https://openalex.org/W6687854690"],"related_works":["https://openalex.org/W2412674874","https://openalex.org/W2402272727","https://openalex.org/W2031089116","https://openalex.org/W175346361","https://openalex.org/W2147376325","https://openalex.org/W2045688816","https://openalex.org/W1979133354","https://openalex.org/W2168377218","https://openalex.org/W2050305231","https://openalex.org/W2153376189"],"abstract_inverted_index":{"Owing":[0],"to":[1,65,112,151,155,192,200],"the":[2,18,28,52],"dramatic":[3],"rise":[4],"in":[5,22,27,78,214],"treatment":[6],"of":[7,30,44,57,68,71,96,106,118,139,159,171,185,203,210,216],"neurological":[8],"disorders":[9],"with":[10,125,134,189],"electrical":[11,69],"micro-stimulation":[12],"it":[13,99],"has":[14,60,84],"become":[15],"apparent":[16],"that":[17,74,102,180],"major":[19],"technological":[20],"limitation":[21],"deploying":[23],"effective":[24],"devices":[25],"lies":[26],"process":[29],"designing":[31],"efficient,":[32],"safe,":[33],"and":[34,41,51,55,63,127,161,206,220],"outcome":[35],"specific":[36],"electrode":[37,164,204],"arrays.":[38],"The":[39],"time-consuming":[40],"low-fidelity":[42],"nature":[43],"gathering":[45],"test":[46],"data":[47],"using":[48,121],"experimental":[49,193],"means":[50],"immense":[53],"control":[54],"flexibility":[56],"computational":[58],"models,":[59],"prompted":[61],"us":[62],"others":[64],"build":[66],"models":[67,95,124],"stimulation":[70,160,173],"neural":[72,97],"networks":[73],"can":[75,148],"be":[76,149],"simulated":[77],"a":[79,114],"computer.":[80],"Because":[81],"prior":[82],"work":[83,196],"been":[85],"focused":[86],"on":[87],"single":[88],"cells,":[89],"very":[90],"small":[91],"networks,":[92],"or":[93],"non-biological":[94],"tissue,":[98,147,172],"was":[100],"expedient":[101],"we":[103],"take":[104],"advantage":[105],"our,":[107],"4,040":[108],"processor,":[109],"computing":[110],"cluster":[111],"construct":[113],"large-scale":[115],"3-dimensional":[116],"emulation":[117],"hippocampal":[119],"tissue":[120,153,162],"detailed":[122],"neuronal":[123,187],"explicit":[126],"unique":[128],"morphologies.":[129],"This":[130,195],"model,":[131],"when":[132],"paired":[133],"an":[135,156,198],"equivalent":[136],"circuit":[137],"method":[138],"estimating":[140],"voltage":[141],"signal":[142],"attenuation":[143],"throughout":[144],"anisotropic":[145],"resistive":[146],"used":[150],"predict":[152],"response":[154],"exhaustive":[157],"set":[158],"conditions:":[163],"geometry,":[165,167],"array":[166],"static":[168],"dielectric":[169],"properties":[170],"pulse":[174],"features,":[175],"etc.":[176],"Preliminary":[177],"experiments":[178],"demonstrate":[179],"this":[181],"system":[182],"is":[183],"capable":[184],"yielding":[186],"responses":[188],"striking":[190],"similarities":[191],"results.":[194],"provides":[197],"avenue":[199],"qualitative":[201],"evaluation":[202],"arrays,":[205],"more":[207],"meaningful":[208],"modeling":[209],"local":[211],"field":[212],"potentials":[213],"terms":[215],"their":[217],"contributing":[218],"sources":[219],"sinks.":[221]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
