{"id":"https://openalex.org/W2533939322","doi":"https://doi.org/10.1109/embc.2016.7591309","title":"Heterogeneous neural amplifier integration for scalable extracellular microelectrodes","display_name":"Heterogeneous neural amplifier integration for scalable extracellular microelectrodes","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2533939322","doi":"https://doi.org/10.1109/embc.2016.7591309","mag":"2533939322","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268897"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591309","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086823889","display_name":"J\u00f6rg Scholvin","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jorg Scholvin","raw_affiliation_strings":["MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009840268","display_name":"Justin P. Kinney","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Justin P. Kinney","raw_affiliation_strings":["MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019978507","display_name":"Jacob Bernstein","orcid":"https://orcid.org/0000-0003-2774-9030"},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob G. Bernstein","raw_affiliation_strings":["MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109400379","display_name":"Caroline Moore-Kochlacs","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Moore-Kochlacs","raw_affiliation_strings":["Boston University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077516931","display_name":"Nancy Kopell","orcid":"https://orcid.org/0000-0002-8568-8750"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy J. Kopell","raw_affiliation_strings":["Boston University, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Boston University, Boston, MA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108225886","display_name":"Clifton G. Fonstad","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifton G. Fonstad","raw_affiliation_strings":["Department of Electrical Engineering and Computer Science, MIT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, MIT","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109593948","display_name":"Edward S. Boyden","orcid":null},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward S. Boyden","raw_affiliation_strings":["MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8418,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.71867501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2016","issue":null,"first_page":"2789","last_page":"2793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.704029381275177},{"id":"https://openalex.org/keywords/amplifier","display_name":"Amplifier","score":0.6535582542419434},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5196079611778259},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.5013632774353027},{"id":"https://openalex.org/keywords/modular-design","display_name":"Modular design","score":0.4978301525115967},{"id":"https://openalex.org/keywords/electronic-engineering","display_name":"Electronic engineering","score":0.496905118227005},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.470201313495636},{"id":"https://openalex.org/keywords/multielectrode-array","display_name":"Multielectrode array","score":0.464205801486969},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.44953611493110657},{"id":"https://openalex.org/keywords/scaling","display_name":"Scaling","score":0.4484430253505707},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.4340871274471283},{"id":"https://openalex.org/keywords/electrical-impedance","display_name":"Electrical impedance","score":0.42661598324775696},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.41325607895851135},{"id":"https://openalex.org/keywords/cmos","display_name":"CMOS","score":0.30960172414779663},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.2814345359802246},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.23732107877731323},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.1290741264820099},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.12780660390853882},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.07927492260932922},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.0766647458076477}],"concepts":[{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.704029381275177},{"id":"https://openalex.org/C194257627","wikidata":"https://www.wikidata.org/wiki/Q211554","display_name":"Amplifier","level":3,"score":0.6535582542419434},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5196079611778259},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.5013632774353027},{"id":"https://openalex.org/C101468663","wikidata":"https://www.wikidata.org/wiki/Q1620158","display_name":"Modular design","level":2,"score":0.4978301525115967},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.496905118227005},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.470201313495636},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.464205801486969},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.44953611493110657},{"id":"https://openalex.org/C99844830","wikidata":"https://www.wikidata.org/wiki/Q102441924","display_name":"Scaling","level":2,"score":0.4484430253505707},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4340871274471283},{"id":"https://openalex.org/C17829176","wikidata":"https://www.wikidata.org/wiki/Q179043","display_name":"Electrical impedance","level":2,"score":0.42661598324775696},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.41325607895851135},{"id":"https://openalex.org/C46362747","wikidata":"https://www.wikidata.org/wiki/Q173431","display_name":"CMOS","level":2,"score":0.30960172414779663},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.2814345359802246},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.23732107877731323},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1290741264820099},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.12780660390853882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07927492260932922},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0766647458076477},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000669","descriptor_name":"Amplifiers, Electronic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012815","descriptor_name":"Signal Processing, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017097","descriptor_name":"Electric Impedance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7591309","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591309","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268897","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268897","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.4099999964237213,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1893378582","https://openalex.org/W1974867806","https://openalex.org/W2023628599","https://openalex.org/W2036082632","https://openalex.org/W2045701127","https://openalex.org/W2055965799","https://openalex.org/W2065682167","https://openalex.org/W2081826483","https://openalex.org/W2139426119","https://openalex.org/W2259663018","https://openalex.org/W4229594554","https://openalex.org/W6692564225"],"related_works":["https://openalex.org/W2061877343","https://openalex.org/W2028205923","https://openalex.org/W2381760774","https://openalex.org/W2037345099","https://openalex.org/W2964977587","https://openalex.org/W2768056422","https://openalex.org/W2417316355","https://openalex.org/W2354662944","https://openalex.org/W3151450825","https://openalex.org/W2162019548"],"abstract_inverted_index":{"We":[0,30],"here":[1],"demonstrate":[2],"multi-chip":[3],"heterogeneous":[4,71],"integration":[5,72],"of":[6,37],"microfabricated":[7,80],"extracellular":[8],"recording":[9,42,96],"electrodes":[10,97],"with":[11,58],"neural":[12,41,53,81,99],"amplifiers,":[13],"highlighting":[14],"a":[15,85],"path":[16,87],"to":[17,56],"scaling":[18,77,93],"electrode":[19],"channel":[20],"counts":[21],"without":[22],"the":[23,32,38,46,51,59,66],"need":[24],"for":[25,79,88],"more":[26],"complex":[27],"monolithic":[28],"integration.":[29],"characterize":[31],"noise":[33],"and":[34,44,61,83,91,98],"impedance":[35],"performance":[36],"heterogeneously":[39],"integrated":[40],"electrodes,":[43],"analyze":[45],"design":[47,86],"parameters":[48],"that":[49],"enable":[50,75],"low-voltage":[52],"input":[54],"signals":[55],"co-exist":[57],"high-frequency":[60],"high-voltage":[62],"digital":[63],"outputs":[64],"on":[65],"same":[67],"silicon":[68],"substrate.":[69],"This":[70],"approach":[73],"can":[74],"future":[76],"efforts":[78],"probes,":[82],"provides":[84],"modular,":[89],"fast,":[90],"independent":[92],"innovations":[94],"in":[95],"amplifiers.":[100]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}