{"id":"https://openalex.org/W2533651723","doi":"https://doi.org/10.1109/embc.2016.7591032","title":"A mathematical model of ultradian sleep-wake regulation in rodents","display_name":"A mathematical model of ultradian sleep-wake regulation in rodents","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2533651723","doi":"https://doi.org/10.1109/embc.2016.7591032","mag":"2533651723","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268648"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7591032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100982649","display_name":"Hao Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Department of Biomedical Engineering, University of Kentucky"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091431299","display_name":"Farid Yaghouby","orcid":"https://orcid.org/0000-0002-5380-2483"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farid Yaghouby","raw_affiliation_strings":["Department of Biomedical Engineering, University of Kentucky"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041765061","display_name":"Sridhar Sunderam","orcid":"https://orcid.org/0000-0002-2457-6157"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Sunderam","raw_affiliation_strings":["Department of Biomedical Engineering, University of Kentucky"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Kentucky","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100982649"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10244769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2016","issue":null,"first_page":"1656","last_page":"1659"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9650999903678894,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultradian-rhythm","display_name":"Ultradian rhythm","score":0.945726752281189},{"id":"https://openalex.org/keywords/wake","display_name":"Wake","score":0.7676693201065063},{"id":"https://openalex.org/keywords/sleep","display_name":"Sleep (system call)","score":0.45495808124542236},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.43864381313323975},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26288896799087524},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.24339386820793152},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"Circadian rhythm","score":0.22910797595977783},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11364740133285522},{"id":"https://openalex.org/keywords/aerospace-engineering","display_name":"Aerospace engineering","score":0.08104565739631653}],"concepts":[{"id":"https://openalex.org/C136792703","wikidata":"https://www.wikidata.org/wiki/Q377893","display_name":"Ultradian rhythm","level":3,"score":0.945726752281189},{"id":"https://openalex.org/C48939323","wikidata":"https://www.wikidata.org/wiki/Q294879","display_name":"Wake","level":2,"score":0.7676693201065063},{"id":"https://openalex.org/C2775841894","wikidata":"https://www.wikidata.org/wiki/Q4683692","display_name":"Sleep (system call)","level":2,"score":0.45495808124542236},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.43864381313323975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26288896799087524},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24339386820793152},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.22910797595977783},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11364740133285522},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.08104565739631653},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001143","descriptor_name":"Arousal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012890","descriptor_name":"Sleep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014851","descriptor_name":"Wakefulness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7591032","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7591032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268648","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1973592658","https://openalex.org/W1990536075","https://openalex.org/W2004945722","https://openalex.org/W2016354087","https://openalex.org/W2033733716","https://openalex.org/W2046424015","https://openalex.org/W2114915160","https://openalex.org/W2120543763","https://openalex.org/W2123400242","https://openalex.org/W2132816179","https://openalex.org/W2167480019","https://openalex.org/W2272349904","https://openalex.org/W2319421743"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W80206153","https://openalex.org/W2555438545","https://openalex.org/W4387523829","https://openalex.org/W2024796694","https://openalex.org/W2410967782","https://openalex.org/W2113835591","https://openalex.org/W2583443600","https://openalex.org/W94577721"],"abstract_inverted_index":{"Rodent":[0],"models":[1,69],"are":[2],"widely":[3],"used":[4],"for":[5],"the":[6,24,47,71,80,99,109,117,129],"experimental":[7],"analysis":[8],"of":[9,37,49,74,94,102,120],"sleep.":[10],"While":[11],"this":[12],"is":[13,32,55],"motivated":[14,67],"by":[15,57],"similarities":[16],"in":[17,28,44,106,132,137],"brain":[18],"circuitry":[19],"and":[20,39,104,123],"electrophysiological":[21],"rhythms,":[22],"unlike":[23],"circadian":[25,130],"sleep-wake":[26],"cycle":[27],"humans,":[29],"rodent":[30],"sleep":[31,38,53,96,103,122],"polyphasic,":[33],"containing":[34],"multiple":[35],"bouts":[36,125],"wake":[40,124],"minutes":[41,64],"to":[42,63,97],"hours":[43],"duration":[45],"over":[46],"course":[48],"a":[50,89],"day.":[51],"Each":[52],"bout":[54,134],"punctuated":[56],"several":[58,61],"brief":[59],"arousals":[60],"seconds":[62],"long.":[65],"Physiologically":[66],"mathematical":[68],"replicate":[70],"shorter":[72],"timescale":[73],"arousal":[75],"within":[76],"sleep,":[77],"but":[78],"not":[79],"longer":[81,110],"one":[82],"representing":[83],"prolonged":[84],"wakefulness.":[85],"Here,":[86],"we":[87],"adapt":[88],"previously":[90],"published":[91],"\"flip-flop\"":[92],"model":[93,114],"human":[95],"capture":[98],"ultradian":[100],"alternation":[101],"wakefulness":[105],"mice":[107],"on":[108,140],"timescale.":[111],"The":[112],"resulting":[113],"reproduces":[115],"both":[116],"mean":[118],"durations":[119,135],"alternating":[121],"as":[126,128],"well":[127],"trends":[131],"their":[133],"documented":[136],"our":[138],"experiments":[139],"mice.":[141]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}