{"id":"https://openalex.org/W2533878847","doi":"https://doi.org/10.1109/embc.2016.7590985","title":"Host-aware modelling of a synthetic genetic oscillator","display_name":"Host-aware modelling of a synthetic genetic oscillator","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2533878847","doi":"https://doi.org/10.1109/embc.2016.7590985","mag":"2533878847","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268602"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7590985","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590985","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067923983","display_name":"Alexander P. S. Darlington","orcid":"https://orcid.org/0000-0001-8025-6329"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alexander Darlington","raw_affiliation_strings":["Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I39555362"],"apc_list":null,"apc_paid":null,"fwci":0.8511,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.80770708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2016","issue":null,"first_page":"1463","last_page":"1466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11975","display_name":"Evolutionary Algorithms and Applications","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9904999732971191,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.7309134006500244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6946258544921875},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.6558504104614258},{"id":"https://openalex.org/keywords/electronic-circuit","display_name":"Electronic circuit","score":0.457317054271698},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4179172217845917},{"id":"https://openalex.org/keywords/computer-architecture","display_name":"Computer architecture","score":0.3417348265647888},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.14082211256027222},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.13691586256027222},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1125478446483612},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.08902761340141296},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.07833492755889893}],"concepts":[{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.7309134006500244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6946258544921875},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6558504104614258},{"id":"https://openalex.org/C134146338","wikidata":"https://www.wikidata.org/wiki/Q1815901","display_name":"Electronic circuit","level":2,"score":0.457317054271698},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4179172217845917},{"id":"https://openalex.org/C118524514","wikidata":"https://www.wikidata.org/wiki/Q173212","display_name":"Computer architecture","level":1,"score":0.3417348265647888},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.14082211256027222},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.13691586256027222},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1125478446483612},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08902761340141296},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.07833492755889893},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7590985","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590985","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268602","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1528051627","https://openalex.org/W1963204303","https://openalex.org/W1966645118","https://openalex.org/W1970971896","https://openalex.org/W2037913229","https://openalex.org/W2076477598","https://openalex.org/W2087504899","https://openalex.org/W2132828256","https://openalex.org/W2137871876"],"related_works":["https://openalex.org/W3141738981","https://openalex.org/W2099102792","https://openalex.org/W4254255930","https://openalex.org/W4377564965","https://openalex.org/W4205129443","https://openalex.org/W2009687716","https://openalex.org/W634364059","https://openalex.org/W4250188017","https://openalex.org/W2555186193","https://openalex.org/W2153914641"],"abstract_inverted_index":{"Synthetic":[0],"genetic":[1],"circuits":[2],"sometimes":[3],"exhibit":[4],"unexpected":[5],"functionality":[6],"or":[7],"even":[8],"fail":[9],"entirely":[10],"when":[11],"implemented":[12],"in":[13,30,43,70,73,85],"vivo,":[14],"due":[15],"to":[16,79,90],"the":[17,22,31,39,48,66,77],"effects":[18,40,60],"of":[19,50,65,82],"interactions":[20,84],"with":[21],"host":[23],"cell":[24],"that":[25,41,57,88],"were":[26],"not":[27],"accounted":[28],"for":[29,96],"circuit's":[32],"design.":[33],"In":[34],"this":[35],"paper,":[36],"we":[37],"consider":[38],"limitations":[42],"cellular":[44,53],"resources":[45],"have":[46],"on":[47],"dynamics":[49],"a":[51,62],"synthetic":[52,67,97],"oscillator.":[54],"We":[55],"show":[56],"incorporating":[58],"these":[59],"into":[61],"host-aware":[63],"model":[64],"oscillator":[68],"results":[69],"significant":[71],"changes":[72],"its":[74],"dynamics,":[75],"highlighting":[76],"need":[78],"take":[80],"account":[81],"host-circuit":[83],"mathematical":[86],"models":[87],"are":[89],"be":[91],"used":[92],"as":[93],"CAD":[94],"tools":[95],"circuitry.":[98]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}