{"id":"https://openalex.org/W2535389728","doi":"https://doi.org/10.1109/embc.2016.7590929","title":"A chicken embryo cardiac outflow tract atlas for registering changes due to abnormal blood flow","display_name":"A chicken embryo cardiac outflow tract atlas for registering changes due to abnormal blood flow","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2535389728","doi":"https://doi.org/10.1109/embc.2016.7590929","mag":"2535389728","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268548"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7590929","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5475363","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078550956","display_name":"James P. Carson","orcid":"https://orcid.org/0000-0001-9009-5645"},"institutions":[{"id":"https://openalex.org/I4388891828","display_name":"Texas Advanced Computing Center","ror":"https://ror.org/00xg4bh43","country_code":null,"type":"facility","lineage":["https://openalex.org/I4388891828","https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. Carson","raw_affiliation_strings":["Texas Advanced Computing Center, University of Texas, Austin, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Advanced Computing Center, University of Texas, Austin, TX, USA","institution_ids":["https://openalex.org/I4388891828"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042401678","display_name":"Monique Y. Rennie","orcid":"https://orcid.org/0000-0003-2919-2221"},"institutions":[{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Monique Y. Rennie","raw_affiliation_strings":["Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005089361","display_name":"Michael V. Danilchik","orcid":"https://orcid.org/0000-0003-2282-496X"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Danilchik","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084158432","display_name":"Kent L. Thornburg","orcid":"https://orcid.org/0000-0002-5561-4785"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kent Thornburg","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052575593","display_name":"Sandra Rugonyi","orcid":"https://orcid.org/0000-0001-9262-7959"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sandra Rugonyi","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3482,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.69498076,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2003","issue":null,"first_page":"1236","last_page":"1239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subdivision","display_name":"Subdivision","score":0.674248218536377},{"id":"https://openalex.org/keywords/outflow","display_name":"Outflow","score":0.6714977025985718},{"id":"https://openalex.org/keywords/atlas","display_name":"Atlas (anatomy)","score":0.5995856523513794},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.5927236676216125},{"id":"https://openalex.org/keywords/heart-disease","display_name":"Heart disease","score":0.5524123907089233},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.5039162039756775},{"id":"https://openalex.org/keywords/cardiac-cycle","display_name":"Cardiac cycle","score":0.47903504967689514},{"id":"https://openalex.org/keywords/ventricular-outflow-tract","display_name":"Ventricular outflow tract","score":0.47105953097343445},{"id":"https://openalex.org/keywords/embryonic-heart","display_name":"Embryonic heart","score":0.4514464735984802},{"id":"https://openalex.org/keywords/embryonic-stem-cell","display_name":"Embryonic stem cell","score":0.44267839193344116},{"id":"https://openalex.org/keywords/great-vessels","display_name":"Great vessels","score":0.43602418899536133},{"id":"https://openalex.org/keywords/heart-development","display_name":"Heart development","score":0.419981986284256},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39896705746650696},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3955345153808594},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3751150369644165},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34163957834243774},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.24756526947021484},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13358256220817566},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12171989679336548},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11451059579849243}],"concepts":[{"id":"https://openalex.org/C143392562","wikidata":"https://www.wikidata.org/wiki/Q449111","display_name":"Subdivision","level":2,"score":0.674248218536377},{"id":"https://openalex.org/C86132830","wikidata":"https://www.wikidata.org/wiki/Q3308838","display_name":"Outflow","level":2,"score":0.6714977025985718},{"id":"https://openalex.org/C2776673561","wikidata":"https://www.wikidata.org/wiki/Q655357","display_name":"Atlas (anatomy)","level":2,"score":0.5995856523513794},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5927236676216125},{"id":"https://openalex.org/C2780074459","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Heart disease","level":2,"score":0.5524123907089233},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5039162039756775},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.47903504967689514},{"id":"https://openalex.org/C2777361368","wikidata":"https://www.wikidata.org/wiki/Q7920318","display_name":"Ventricular outflow tract","level":2,"score":0.47105953097343445},{"id":"https://openalex.org/C2777837822","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Embryonic heart","level":4,"score":0.4514464735984802},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.44267839193344116},{"id":"https://openalex.org/C2775877586","wikidata":"https://www.wikidata.org/wiki/Q5600417","display_name":"Great vessels","level":2,"score":0.43602418899536133},{"id":"https://openalex.org/C62425271","wikidata":"https://www.wikidata.org/wiki/Q14819288","display_name":"Heart development","level":4,"score":0.419981986284256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39896705746650696},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3955345153808594},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3751150369644165},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34163957834243774},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.24756526947021484},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13358256220817566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12171989679336548},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11451059579849243},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006330","descriptor_name":"Heart Defects, Congenital","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2016.7590929","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590929","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268548","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5475363","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5475363","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5475363","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5475363","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[{"score":0.7099999785423279,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309650","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W173658555","https://openalex.org/W1513220135","https://openalex.org/W1528814089","https://openalex.org/W1967359970","https://openalex.org/W1970516435","https://openalex.org/W1983344263","https://openalex.org/W1989249522","https://openalex.org/W1996826335","https://openalex.org/W2053275091","https://openalex.org/W2059141827","https://openalex.org/W2089247555","https://openalex.org/W2100568348","https://openalex.org/W2105490800","https://openalex.org/W2105966117","https://openalex.org/W2114451602","https://openalex.org/W2115721055","https://openalex.org/W2128649708","https://openalex.org/W2140034535","https://openalex.org/W2144303871","https://openalex.org/W2147772045","https://openalex.org/W2151139811","https://openalex.org/W2155982530","https://openalex.org/W2162753672","https://openalex.org/W2488002172","https://openalex.org/W2993832498","https://openalex.org/W4211191293","https://openalex.org/W6681380582","https://openalex.org/W6722742552","https://openalex.org/W6771550045"],"related_works":["https://openalex.org/W1999648333","https://openalex.org/W2072140352","https://openalex.org/W2937867040","https://openalex.org/W4298385568","https://openalex.org/W4312201129","https://openalex.org/W2089440568","https://openalex.org/W1529638073","https://openalex.org/W3123810745","https://openalex.org/W3195728881","https://openalex.org/W4295213601"],"abstract_inverted_index":{"Subdivision-based":[0],"image":[1],"registration":[2],"has":[3],"previously":[4],"been":[5],"applied":[6],"to":[7,52,89],"co-localize":[8],"digital":[9],"information":[10],"extracted":[11],"from":[12],"rigid":[13],"structures":[14],"in":[15,71,82,107,113],"biological":[16],"specimens,":[17],"such":[18],"as":[19],"the":[20,27,40,44,59,66,83,109,116,124,133,137],"brain.":[21],"Here,":[22],"we":[23],"describe":[24],"and":[25,29,62,74,96,118,126],"demonstrate":[26],"creation":[28],"application":[30],"of":[31,43,58,68,115,132],"a":[32,37],"two-dimensional":[33],"subdivision-based":[34,134],"atlas":[35,49,135],"representing":[36],"dynamic":[38],"structure:":[39],"outflow":[41,60],"tract":[42],"developing":[45,85],"chicken":[46,139],"heart.":[47,140],"The":[48],"is":[50,63],"designed":[51],"segment":[53],"three":[54],"different":[55],"anatomical":[56],"layers":[57],"tract,":[61],"demonstrated":[64],"on":[65],"characterization":[67],"collagen":[69],"XIV":[70],"both":[72],"control":[73],"induced":[75],"abnormal":[76,103],"flow":[77,81,104],"specimens.":[78],"Abnormal":[79],"blood":[80],"embryonic":[84,138],"heart":[86,91,117],"can":[87,105],"lead":[88],"congenital":[90,119],"disease.":[92],"Comparing":[93],"local":[94],"cellular":[95],"sub-cellular":[97],"changes":[98],"that":[99],"are":[100],"caused":[101],"by":[102],"assist":[106],"understanding":[108],"molecular":[110],"pathways":[111],"involved":[112],"maladaptations":[114],"defects.":[120],"This":[121],"study":[122],"demonstrates":[123],"approach":[125],"potential":[127],"for":[128,136],"more":[129],"extensive":[130],"applications":[131]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}