{"id":"https://openalex.org/W2534128614","doi":"https://doi.org/10.1109/embc.2016.7590648","title":"A challenging issue: Detection of white matter hyperintensities in neonatal brain MRI","display_name":"A challenging issue: Detection of white matter hyperintensities in neonatal brain MRI","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2534128614","doi":"https://doi.org/10.1109/embc.2016.7590648","mag":"2534128614","pmid":"https://pubmed.ncbi.nlm.nih.gov/28268289"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2016.7590648","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590648","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089979015","display_name":"Baptiste Morel","orcid":"https://orcid.org/0000-0003-4747-3393"},"institutions":[{"id":"https://openalex.org/I110017253","display_name":"Universit\u00e9 de Tours","ror":"https://ror.org/02wwzvj46","country_code":"FR","type":"education","lineage":["https://openalex.org/I110017253"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210165912","display_name":"Laboratoire Traitement et Communication de l\u2019Information","ror":"https://ror.org/057er4c39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12356871","https://openalex.org/I205703379","https://openalex.org/I4210145102","https://openalex.org/I4210165912"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Baptiste Morel","raw_affiliation_strings":["Faculty of Medicine, Fran\u00e7ois Rabelais University, Tours, France","LTCI, Universit\u00e9 Paris-Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Fran\u00e7ois Rabelais University, Tours, France","institution_ids":["https://openalex.org/I110017253"]},{"raw_affiliation_string":"LTCI, Universit\u00e9 Paris-Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210165912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082564408","display_name":"Yongchao Xu","orcid":"https://orcid.org/0000-0002-7253-3151"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210126302","display_name":"Syst\u00e8mes d'Elevage M\u00e9diterran\u00e9ens et Tropicaux - Laboratoire de Recherche sur le D\u00e9veloppement de l'Elevage","ror":"https://ror.org/03p371w23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210126302"]},{"id":"https://openalex.org/I4210138808","display_name":"\u00c9cole Pour l'Informatique et les Techniques Avanc\u00e9es","ror":"https://ror.org/04r5ddq29","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210138808"]},{"id":"https://openalex.org/I4210165912","display_name":"Laboratoire Traitement et Communication de l\u2019Information","ror":"https://ror.org/057er4c39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12356871","https://openalex.org/I205703379","https://openalex.org/I4210145102","https://openalex.org/I4210165912"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yongchao Xu","raw_affiliation_strings":["EPITA Research and Development Laboratory (LRDE), France","LTCI, Universit\u00e9 Paris-Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPITA Research and Development Laboratory (LRDE), France","institution_ids":["https://openalex.org/I4210126302","https://openalex.org/I4210138808"]},{"raw_affiliation_string":"LTCI, Universit\u00e9 Paris-Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210165912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010942533","display_name":"Alessio Virz\u00ec","orcid":"https://orcid.org/0000-0001-7956-3006"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210165912","display_name":"Laboratoire Traitement et Communication de l\u2019Information","ror":"https://ror.org/057er4c39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12356871","https://openalex.org/I205703379","https://openalex.org/I4210145102","https://openalex.org/I4210165912"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alessio Virzi","raw_affiliation_strings":["LTCI, Universit\u00e9 Paris-Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LTCI, Universit\u00e9 Paris-Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210165912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068813606","display_name":"Thierry G\u00e9raud","orcid":"https://orcid.org/0000-0002-0380-7948"},"institutions":[{"id":"https://openalex.org/I4210126302","display_name":"Syst\u00e8mes d'Elevage M\u00e9diterran\u00e9ens et Tropicaux - Laboratoire de Recherche sur le D\u00e9veloppement de l'Elevage","ror":"https://ror.org/03p371w23","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210126302"]},{"id":"https://openalex.org/I4210138808","display_name":"\u00c9cole Pour l'Informatique et les Techniques Avanc\u00e9es","ror":"https://ror.org/04r5ddq29","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210138808"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Thierry Geraud","raw_affiliation_strings":["EPITA Research and Development Laboratory (LRDE), France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EPITA Research and Development Laboratory (LRDE), France","institution_ids":["https://openalex.org/I4210126302","https://openalex.org/I4210138808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086032102","display_name":"C. Adamsbaum","orcid":"https://orcid.org/0000-0003-1067-0529"},"institutions":[{"id":"https://openalex.org/I102197404","display_name":"Universit\u00e9 Paris-Sud","ror":"https://ror.org/028rypz17","country_code":"FR","type":"education","lineage":["https://openalex.org/I102197404"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210165912","display_name":"Laboratoire Traitement et Communication de l\u2019Information","ror":"https://ror.org/057er4c39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12356871","https://openalex.org/I205703379","https://openalex.org/I4210145102","https://openalex.org/I4210165912"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Catherine Adamsbaum","raw_affiliation_strings":["Faculty of Medicine, Paris Sud University, Paris, France","LTCI, Universit\u00e9 Paris-Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Paris Sud University, Paris, France","institution_ids":["https://openalex.org/I102197404"]},{"raw_affiliation_string":"LTCI, Universit\u00e9 Paris-Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210165912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088407901","display_name":"Isabelle Bloch","orcid":"https://orcid.org/0000-0002-6984-1532"},"institutions":[{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210165912","display_name":"Laboratoire Traitement et Communication de l\u2019Information","ror":"https://ror.org/057er4c39","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12356871","https://openalex.org/I205703379","https://openalex.org/I4210145102","https://openalex.org/I4210165912"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Bloch","raw_affiliation_strings":["LTCI, Universit\u00e9 Paris-Saclay, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LTCI, Universit\u00e9 Paris-Saclay, Paris, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210165912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2016","issue":null,"first_page":"93","last_page":"96"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperintensity","display_name":"Hyperintensity","score":0.8911241292953491},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.7236176133155823},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6707344055175781},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6070436239242554},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.57902991771698},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5709290504455566},{"id":"https://openalex.org/keywords/reproducibility","display_name":"Reproducibility","score":0.4358961284160614},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4358457326889038},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3338836431503296},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2330327332019806},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.1756218671798706},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15276014804840088},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.0828014612197876},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.06552490592002869}],"concepts":[{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.8911241292953491},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7236176133155823},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6707344055175781},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6070436239242554},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.57902991771698},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5709290504455566},{"id":"https://openalex.org/C9893847","wikidata":"https://www.wikidata.org/wiki/Q1425625","display_name":"Reproducibility","level":2,"score":0.4358961284160614},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4358457326889038},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3338836431503296},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2330327332019806},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.1756218671798706},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15276014804840088},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0828014612197876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06552490592002869},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007234","descriptor_name":"Infant, Premature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2016.7590648","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2016.7590648","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:28268289","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28268289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W2038983616","https://openalex.org/W2049791419","https://openalex.org/W2074585180","https://openalex.org/W2079141380","https://openalex.org/W2097920866","https://openalex.org/W2113168810","https://openalex.org/W2133059825","https://openalex.org/W2136042863","https://openalex.org/W2140696958","https://openalex.org/W2146712216","https://openalex.org/W2146842130","https://openalex.org/W2150134853","https://openalex.org/W2161386579","https://openalex.org/W2166170436","https://openalex.org/W2169191514","https://openalex.org/W2293635884","https://openalex.org/W6683655800","https://openalex.org/W6684473977"],"related_works":["https://openalex.org/W2413717610","https://openalex.org/W1973270181","https://openalex.org/W2417696084","https://openalex.org/W2368782778","https://openalex.org/W2087830269","https://openalex.org/W3106281778","https://openalex.org/W2003643616","https://openalex.org/W638612878","https://openalex.org/W3092209499","https://openalex.org/W2101112453"],"abstract_inverted_index":{"The":[0,22],"progress":[1],"of":[2,12,15,30,34,43,47,57],"magnetic":[3],"resonance":[4],"imaging":[5],"(MRI)":[6],"allows":[7],"for":[8],"a":[9,38,51,72],"precise":[10],"exploration":[11],"the":[13,31],"brain":[14],"premature":[16,35],"infants":[17],"at":[18],"term":[19],"equivalent":[20],"age.":[21],"so-called":[23],"DEHSI":[24],"(diffuse":[25],"excessive":[26],"high":[27],"signal":[28],"intensity)":[29],"white":[32,58],"matter":[33,59],"brains":[36],"remains":[37],"challenging":[39],"issue":[40],"in":[41,61],"terms":[42],"definition,":[44],"and":[45,54,67,86],"thus":[46],"interpretation.":[48,81],"We":[49],"propose":[50],"semi-automatic":[52],"detection":[53],"quantification":[55],"method":[56],"hyperintensities":[60],"MRI":[62],"relying":[63],"on":[64],"morphological":[65],"operators":[66],"max-tree":[68],"representations,":[69],"which":[70],"constitutes":[71],"powerful":[73],"tool":[74],"to":[75,78],"help":[76],"radiologists":[77],"improve":[79],"their":[80],"Results":[82],"show":[83],"better":[84],"reproducibility":[85],"robustness":[87],"than":[88],"interactive":[89],"segmentation.":[90]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}