{"id":"https://openalex.org/W2295398177","doi":"https://doi.org/10.1109/embc.2015.7320294","title":"Integrative analysis of LC-MS based glycomic and proteomic data","display_name":"Integrative analysis of LC-MS based glycomic and proteomic data","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2295398177","doi":"https://doi.org/10.1109/embc.2015.7320294","mag":"2295398177","pmid":"https://pubmed.ncbi.nlm.nih.gov/26738194"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7320294","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320294","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4838186","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074522619","display_name":"Minkun Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Minkun Wang","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076006520","display_name":"Guoqiang Yu","orcid":"https://orcid.org/0000-0002-6743-7413"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoqiang Yu","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Virginia Tech, Arlington, VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025125310","display_name":"Habtom W. Ressom","orcid":"https://orcid.org/0000-0001-9296-2132"},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Habtom W. Ressom","raw_affiliation_strings":["Department of Oncology, Georgetown University, Washington, DC, USA"],"affiliations":[{"raw_affiliation_string":"Department of Oncology, Georgetown University, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074522619"],"corresponding_institution_ids":["https://openalex.org/I859038795"],"apc_list":null,"apc_paid":null,"fwci":0.3013,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.63387775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2015","issue":null,"first_page":"8185","last_page":"8188"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycan","display_name":"Glycan","score":0.7372512817382812},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.640687882900238},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4751731753349304},{"id":"https://openalex.org/keywords/glycomics","display_name":"Glycomics","score":0.47330132126808167},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.46869826316833496},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.45726853609085083},{"id":"https://openalex.org/keywords/cirrhosis","display_name":"Cirrhosis","score":0.4235707223415375},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.4167505204677582},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38681185245513916},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3578694462776184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3027490973472595},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.29429540038108826},{"id":"https://openalex.org/keywords/glycoprotein","display_name":"Glycoprotein","score":0.2808520793914795},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2588244080543518},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.23196661472320557},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22144865989685059},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16757887601852417},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14209511876106262},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09374794363975525}],"concepts":[{"id":"https://openalex.org/C206212055","wikidata":"https://www.wikidata.org/wiki/Q2553138","display_name":"Glycan","level":3,"score":0.7372512817382812},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.640687882900238},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4751731753349304},{"id":"https://openalex.org/C106686826","wikidata":"https://www.wikidata.org/wiki/Q741206","display_name":"Glycomics","level":4,"score":0.47330132126808167},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.46869826316833496},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.45726853609085083},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.4235707223415375},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.4167505204677582},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38681185245513916},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3578694462776184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3027490973472595},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29429540038108826},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.2808520793914795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2588244080543518},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.23196661472320557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22144865989685059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16757887601852417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14209511876106262},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09374794363975525},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054794","descriptor_name":"Glycomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054794","descriptor_name":"Glycomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D054794","descriptor_name":"Glycomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2015.7320294","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320294","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26738194","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26738194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4838186","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4838186","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4838186","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4838186","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W2002528827","https://openalex.org/W2017777108","https://openalex.org/W2052644289","https://openalex.org/W2059529313","https://openalex.org/W2096801725","https://openalex.org/W2141091417","https://openalex.org/W2143426320","https://openalex.org/W2315438426"],"related_works":["https://openalex.org/W2344851944","https://openalex.org/W4307946532","https://openalex.org/W4386770953","https://openalex.org/W2076975212","https://openalex.org/W2952690209","https://openalex.org/W2051926957","https://openalex.org/W1965354942","https://openalex.org/W2909198132","https://openalex.org/W2586793552","https://openalex.org/W2028136243"],"abstract_inverted_index":{"Studies":[0],"associating":[1],"changes":[2],"in":[3,26,118,137],"the":[4,11,55,61,85],"levels":[5],"of":[6,13,39,47,74,102,113],"glycans":[7,48,75],"and":[8,36,49,76,104,134],"proteins":[9,50,77,105],"with":[10,144],"onset":[12],"cancer":[14,89,121,140],"have":[15,32,51],"been":[16,52,64],"widely":[17],"investigated":[18],"to":[19,78,83,87,98,131],"identify":[20],"clinically":[21],"relevant":[22],"diagnostic":[23],"biomarkers.":[24],"Advances":[25],"liquid":[27],"chromatography":[28],"mass":[29],"spectrometry":[30],"(LC-MS)":[31],"enabled":[33],"high-throughput":[34],"identification":[35],"quantitative":[37],"analysis":[38,73,112,129],"these":[40],"biomolecules.":[41],"While":[42],"results":[43],"from":[44,91,106,115,142],"separate":[45,132],"analyses":[46],"reported":[53],"widely,":[54],"mutual":[56],"information":[57,82],"obtained":[58],"by":[59,111,127],"combining":[60],"two":[62,116],"has":[63],"relatively":[65],"unexplored.":[66],"In":[67],"this":[68],"study,":[69],"we":[70],"investigate":[71],"integrative":[72,128],"take":[79],"advantage":[80],"complementary":[81],"improve":[84],"ability":[86],"distinguish":[88],"cases":[90,141],"controls.":[92],"Specifically,":[93],"SVM-RFE":[94],"algorithm":[95],"is":[96],"utilized":[97],"select":[99],"a":[100,119],"panel":[101],"N-glycans":[103],"LC-MS":[107],"data":[108],"previously":[109],"acquired":[110],"sera":[114],"cohorts":[117],"liver":[120,139,145],"study.":[122],"Improved":[123],"performances":[124],"are":[125],"observed":[126],"compared":[130],"glycomic":[133],"proteomic":[135],"studies":[136],"distinguishing":[138],"patients":[143],"cirrhosis.":[146]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
