{"id":"https://openalex.org/W2295320222","doi":"https://doi.org/10.1109/embc.2015.7320285","title":"Simulation of cellular changes on Optical Coherence Tomography of human retina","display_name":"Simulation of cellular changes on Optical Coherence Tomography of human retina","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2295320222","doi":"https://doi.org/10.1109/embc.2015.7320285","mag":"2295320222","pmid":"https://pubmed.ncbi.nlm.nih.gov/26738185"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7320285","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017034254","display_name":"Miriam Seoane Santos","orcid":"https://orcid.org/0000-0002-5912-963X"},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Miriam Santos","raw_affiliation_strings":["AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052356431","display_name":"Ad\u00e9rito Ara\u00fajo","orcid":"https://orcid.org/0000-0002-9873-5974"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Aderito Araujo","raw_affiliation_strings":["Department of Mathematics, University of Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070343607","display_name":"S\u00edlvia Barbeiro","orcid":"https://orcid.org/0000-0002-2651-5083"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Silvia Barbeiro","raw_affiliation_strings":["Department of Mathematics, University of Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022065316","display_name":"Francisco Caramelo","orcid":"https://orcid.org/0000-0002-0015-8604"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Francisco Caramelo","raw_affiliation_strings":["Faculty of Medicine, University of'Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of'Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072190058","display_name":"A. Correia","orcid":"https://orcid.org/0000-0002-2964-4665"},"institutions":[{"id":"https://openalex.org/I4210141142","display_name":"Association for Innovation and Biomedical Research on Light and Image","ror":"https://ror.org/03j96wp44","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210141142"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Antonio Correia","raw_affiliation_strings":["AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"AIBILI-Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal","institution_ids":["https://openalex.org/I4210141142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102082412","display_name":"Maria Isabel Marques","orcid":null},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria Isabel Marques","raw_affiliation_strings":["Universidade de Coimbra, Coimbra, Coimbra, PT"],"affiliations":[{"raw_affiliation_string":"Universidade de Coimbra, Coimbra, Coimbra, PT","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090114894","display_name":"Lu\u00eds Pinto","orcid":"https://orcid.org/0000-0003-1121-1738"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Luis Pinto","raw_affiliation_strings":["Department of Mathematics, University of Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003891187","display_name":"Pedro Serranho","orcid":"https://orcid.org/0000-0003-2176-3923"},"institutions":[{"id":"https://openalex.org/I201025148","display_name":"Universidade Aberta","ror":"https://ror.org/02rv3w387","country_code":"PT","type":"education","lineage":["https://openalex.org/I201025148"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Serranho","raw_affiliation_strings":["Mathematics Section, Open University, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"Mathematics Section, Open University, Lisbon, Portugal","institution_ids":["https://openalex.org/I201025148"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064063105","display_name":"Rui Bernardes","orcid":"https://orcid.org/0000-0002-6677-2754"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Bernardes","raw_affiliation_strings":["Faculty of Medicine, University of'Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University of'Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048272453","display_name":"Miguel Morgado","orcid":"https://orcid.org/0000-0001-9455-1206"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel Morgado","raw_affiliation_strings":["Department of Physics, University of Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5017034254"],"corresponding_institution_ids":["https://openalex.org/I4210141142"],"apc_list":null,"apc_paid":null,"fwci":0.9094,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.75549325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2011","issue":null,"first_page":"8147","last_page":"8150"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11569","display_name":"Optical Coherence Tomography Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"Optical coherence tomography","score":0.73929762840271},{"id":"https://openalex.org/keywords/finite-element-method","display_name":"Finite element method","score":0.7023676037788391},{"id":"https://openalex.org/keywords/retina","display_name":"Retina","score":0.6861850619316101},{"id":"https://openalex.org/keywords/coherence","display_name":"Coherence (philosophical gambling strategy)","score":0.5512215495109558},{"id":"https://openalex.org/keywords/optical-tomography","display_name":"Optical tomography","score":0.49345889687538147},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.4894069731235504},{"id":"https://openalex.org/keywords/observable","display_name":"Observable","score":0.48749518394470215},{"id":"https://openalex.org/keywords/mie-scattering","display_name":"Mie scattering","score":0.460651159286499},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.43795520067214966},{"id":"https://openalex.org/keywords/galerkin-method","display_name":"Galerkin method","score":0.41516003012657166},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37486332654953003},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.34211763739585876},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25978824496269226},{"id":"https://openalex.org/keywords/light-scattering","display_name":"Light scattering","score":0.1466081142425537},{"id":"https://openalex.org/keywords/scattering","display_name":"Scattering","score":0.12539783120155334},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.07576382160186768}],"concepts":[{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.73929762840271},{"id":"https://openalex.org/C135628077","wikidata":"https://www.wikidata.org/wiki/Q220184","display_name":"Finite element method","level":2,"score":0.7023676037788391},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.6861850619316101},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.5512215495109558},{"id":"https://openalex.org/C2777413408","wikidata":"https://www.wikidata.org/wiki/Q1968843","display_name":"Optical tomography","level":3,"score":0.49345889687538147},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.4894069731235504},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.48749518394470215},{"id":"https://openalex.org/C63688654","wikidata":"https://www.wikidata.org/wiki/Q901737","display_name":"Mie scattering","level":4,"score":0.460651159286499},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.43795520067214966},{"id":"https://openalex.org/C186899397","wikidata":"https://www.wikidata.org/wiki/Q1491980","display_name":"Galerkin method","level":3,"score":0.41516003012657166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37486332654953003},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.34211763739585876},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25978824496269226},{"id":"https://openalex.org/C120456961","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Light scattering","level":3,"score":0.1466081142425537},{"id":"https://openalex.org/C191486275","wikidata":"https://www.wikidata.org/wiki/Q210028","display_name":"Scattering","level":2,"score":0.12539783120155334},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.07576382160186768},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008269","descriptor_name":"Macular Edema","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D041623","descriptor_name":"Tomography, Optical Coherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7320285","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320285","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26738185","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26738185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W239547030","https://openalex.org/W1570895503","https://openalex.org/W1583515859","https://openalex.org/W1651253804","https://openalex.org/W1974260057","https://openalex.org/W1977897282","https://openalex.org/W1990193209","https://openalex.org/W1993795103","https://openalex.org/W2002363316","https://openalex.org/W2013492930","https://openalex.org/W2016795705","https://openalex.org/W2016806017","https://openalex.org/W2031593273","https://openalex.org/W2073219079","https://openalex.org/W2077026901","https://openalex.org/W2087849319","https://openalex.org/W2087887080","https://openalex.org/W2090843874","https://openalex.org/W2092668319","https://openalex.org/W2097683070","https://openalex.org/W2147708754","https://openalex.org/W2154948345","https://openalex.org/W2278413365","https://openalex.org/W4251197584","https://openalex.org/W6634342761"],"related_works":["https://openalex.org/W2166934110","https://openalex.org/W2028558083","https://openalex.org/W3200823469","https://openalex.org/W2083453785","https://openalex.org/W2001904169","https://openalex.org/W2970707651","https://openalex.org/W2089574289","https://openalex.org/W4385335045","https://openalex.org/W2108584818","https://openalex.org/W2152200284"],"abstract_inverted_index":{"We":[0,101],"present":[1,86,103],"a":[2,42,77],"methodology":[3,38,108],"to":[4,109,128],"assess":[5],"cell":[6,113],"level":[7,114],"alterations":[8,115,131],"on":[9],"the":[10,19,32,50,63,87,110,118,135,139,143],"human":[11,51],"retina":[12],"responsible":[13,116,133],"for":[14,66,98,117,134],"functional":[15],"changes":[16,136],"observable":[17],"in":[18,24,28,31,41,121,138],"Optical":[20],"Coherence":[21],"Tomography":[22],"data":[23,120],"healthy":[25],"ageing":[26],"and":[27,92],"disease":[29],"conditions,":[30],"absence":[33],"of":[34,49,56,70,73,106,112,142],"structural":[35],"alterations.":[36],"The":[37,53],"is":[39],"based":[40],"3D":[43,67,90],"multilayer":[44],"Monte":[45],"Carlo":[46],"computational":[47],"model":[48,91],"retina.":[52],"optical":[54],"properties":[55],"each":[57],"layer":[58],"are":[59,132],"obtained":[60],"by":[61],"solving":[62],"Maxwell's":[64],"equations":[65],"domains":[68],"representative":[69],"small":[71],"regions":[72],"those":[74],"layers,":[75],"using":[76],"Discontinuous":[78],"Galerkin":[79],"Finite":[80],"Element":[81],"Method":[82],"(DG-FEM).":[83],"Here":[84],"we":[85],"DG-FEM":[88],"Maxwell":[89],"its":[93],"validation":[94],"against":[95],"Mie's":[96],"theory":[97],"spherical":[99],"scatterers.":[100],"also":[102],"an":[104],"application":[105],"our":[107],"assessment":[111],"OCT":[119,140],"Diabetic":[122],"Macular":[123],"Edema.":[124],"It":[125],"was":[126],"possible":[127],"identify":[129],"which":[130],"observed":[137],"scans":[141],"diseased":[144],"groups.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}
