{"id":"https://openalex.org/W2296206204","doi":"https://doi.org/10.1109/embc.2015.7320182","title":"Computer-based automatic identification of neurons in gigavoxel-sized 3D human brain images","display_name":"Computer-based automatic identification of neurons in gigavoxel-sized 3D human brain images","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2296206204","doi":"https://doi.org/10.1109/embc.2015.7320182","mag":"2296206204","pmid":"https://pubmed.ncbi.nlm.nih.gov/26738082"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7320182","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320182","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003216983","display_name":"Paolo Soda","orcid":"https://orcid.org/0000-0003-2621-072X"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Paolo Soda","raw_affiliation_strings":["Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055976035","display_name":"Ludovica Acciai","orcid":"https://orcid.org/0000-0001-5241-1758"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ludovica Acciai","raw_affiliation_strings":["Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042081469","display_name":"Ermanno Cordelli","orcid":"https://orcid.org/0000-0001-6062-7575"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ermanno Cordelli","raw_affiliation_strings":["Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044874332","display_name":"Irene Costantini","orcid":"https://orcid.org/0000-0002-8464-7324"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Irene Costantini","raw_affiliation_strings":["European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy"],"affiliations":[{"raw_affiliation_string":"European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070800227","display_name":"Leonardo Sacconi","orcid":"https://orcid.org/0000-0002-9320-5085"},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Leonardo Sacconi","raw_affiliation_strings":["European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy","National Institute of Optics, National Research Council, Florence, Italy"],"affiliations":[{"raw_affiliation_string":"European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"National Institute of Optics, National Research Council, Florence, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054913174","display_name":"Francesco S. Pavone","orcid":"https://orcid.org/0000-0002-0675-3981"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]},{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Saverio Pavone","raw_affiliation_strings":["Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy","European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy","National Institute of Optics, National Research Council, Florence, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Physics and Astronomy, University of Florence, Sesto Fiorentino, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"European Laboratory for Non-linear Spectroscopy, University of Florence, Sesto Fiorentino, Italy","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"National Institute of Optics, National Research Council, Florence, Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005057454","display_name":"Valerio Conti","orcid":"https://orcid.org/0000-0002-8326-6378"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valerio Conti","raw_affiliation_strings":["Department of Neuroscience, Pharmacology and Child Health, University of Florence, Florence, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Pharmacology and Child Health, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009870571","display_name":"Renzo Guerrini","orcid":"https://orcid.org/0000-0002-7272-7079"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Renzo Guerrini","raw_affiliation_strings":["Department of Neuroscience, Pharmacology and Child Health, University of Florence, Florence, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Pharmacology and Child Health, University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027422071","display_name":"Paolo Frasconi","orcid":"https://orcid.org/0000-0003-3117-9245"},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Frasconi","raw_affiliation_strings":["Department of Information Engineering (DINFO), University of Florence, Florence, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering (DINFO), University of Florence, Florence, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084631519","display_name":"Giulio Iannello","orcid":"https://orcid.org/0000-0003-3864-5800"},"institutions":[{"id":"https://openalex.org/I155125353","display_name":"Universit\u00e0 Campus Bio-Medico","ror":"https://ror.org/04gqx4x78","country_code":"IT","type":"education","lineage":["https://openalex.org/I155125353"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giulio Iannello","raw_affiliation_strings":["Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Engineering, University Campus Bio-Medico of Rome, Rome, Italy","institution_ids":["https://openalex.org/I155125353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5003216983"],"corresponding_institution_ids":["https://openalex.org/I155125353"],"apc_list":null,"apc_paid":null,"fwci":0.7981,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.84400437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2015","issue":null,"first_page":"7724","last_page":"7727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9846000075340271,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7074913382530212},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6460983157157898},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5681369304656982},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.4761645495891571},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3544883131980896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07963123917579651}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7074913382530212},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6460983157157898},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5681369304656982},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.4761645495891571},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3544883131980896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07963123917579651},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059906","descriptor_name":"Neuroimaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2015.7320182","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320182","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26738082","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26738082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:flore.unifi.it:2158/1082843","is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/1082843","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8100000023841858,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1585273445","https://openalex.org/W1975389666","https://openalex.org/W1998311047","https://openalex.org/W1999185738","https://openalex.org/W2001412060","https://openalex.org/W2030363891","https://openalex.org/W2036984232","https://openalex.org/W2046451474","https://openalex.org/W2067191022","https://openalex.org/W2076507262","https://openalex.org/W2079130919","https://openalex.org/W2083970667","https://openalex.org/W2105727230","https://openalex.org/W2122111042","https://openalex.org/W2123360522","https://openalex.org/W3103749967"],"related_works":["https://openalex.org/W2058170566","https://openalex.org/W2772917594","https://openalex.org/W2755342338","https://openalex.org/W2166024367","https://openalex.org/W3116076068","https://openalex.org/W2229312674","https://openalex.org/W2951359407","https://openalex.org/W2079911747","https://openalex.org/W1969923398","https://openalex.org/W2775347418"],"abstract_inverted_index":{"Achieving":[0],"a":[1,10,52,92,99,106,117,151],"comprehensive":[2],"knowledge":[3],"of":[4,22,26,33,55,64,101,112,141],"the":[5,16,23,48,74,110,132,139],"human":[6,102,160],"brain":[7,103],"cytoarchitecture":[8],"is":[9],"fundamental":[11],"step":[12],"to":[13,44,69,81,94],"understand":[14],"how":[15],"nervous":[17],"system":[18],"works,":[19],"i.e.,":[20],"one":[21],"greatest":[24],"challenge":[25],"21(st)":[27],"century":[28],"science.":[29],"The":[30,136],"recent":[31],"development":[32],"biological":[34],"tissue":[35],"labeling":[36],"and":[37,84,123,128,145],"automated":[38],"microscopic":[39],"imaging":[40],"systems":[41],"has":[42],"permitted":[43],"acquire":[45],"images":[46],"at":[47,73],"micro-resolution,":[49],"which":[50],"produce":[51],"huge":[53],"quantity":[54],"data":[56],"that":[57],"cannot":[58],"be":[59],"manually":[60],"analyzed.":[61],"In":[62],"case":[63],"mammals":[65],"brain,":[66],"automatic":[67],"methods":[68],"extract":[70],"objective":[71],"information":[72],"microscale":[75],"have":[76],"been":[77],"applied":[78],"until":[79],"now":[80],"mice,":[82],"macaque":[83],"cat":[85],"3D":[86],"volume":[87],"images.":[88],"Here":[89],"we":[90],"report":[91],"method":[93,137],"automatically":[95],"localize":[96],"neurons":[97,122,144],"in":[98,116],"sample":[100],"removed":[104],"during":[105],"surgical":[107],"procedure":[108],"for":[109],"treatments":[111],"drug":[113],"resistant":[114],"epilepsy":[115],"child":[118],"with":[119,150],"hemimegalencephaly,":[120],"whose":[121],"neurites":[124],"were":[125],"fluorescence":[126,134],"labelled":[127,161],"finally":[129],"imaged":[130],"using":[131,155],"two-photon":[133],"microscope.":[135],"provides":[138],"map":[140],"both":[142],"parvalbuminergic":[143],"all":[146],"other":[147],"cells":[148],"nuclei":[149],"satisfactory":[152],"f-score":[153],"measured":[154],"more":[156],"than":[157],"two":[158],"thousand":[159],"soma.":[162]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
