{"id":"https://openalex.org/W2219350157","doi":"https://doi.org/10.1109/embc.2015.7320087","title":"A compound ampoule for large-volume controllable jet injection","display_name":"A compound ampoule for large-volume controllable jet injection","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2219350157","doi":"https://doi.org/10.1109/embc.2015.7320087","mag":"2219350157","pmid":"https://pubmed.ncbi.nlm.nih.gov/26737987"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7320087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063261268","display_name":"Bryan P. Ruddy","orcid":"https://orcid.org/0000-0002-4783-3558"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Bryan P. Ruddy","raw_affiliation_strings":["Department of Engineering Science, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077464349","display_name":"James W. McKeage","orcid":"https://orcid.org/0000-0001-5692-7030"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"James W. Mckeage","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081457622","display_name":"Rhys M. J. Williams","orcid":"https://orcid.org/0000-0003-1081-5935"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Rhys M. J. Williams","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087987376","display_name":"Poul M. F. Nielsen","orcid":"https://orcid.org/0000-0002-4704-0179"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Poul M. F. Nielsen","raw_affiliation_strings":["Department of Engineering Science, University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering Science, University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041259670","display_name":"Andrew J. Taberner","orcid":"https://orcid.org/0000-0002-0452-0308"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Andrew J. Taberner","raw_affiliation_strings":["The University of Auckland, Auckland, Auckland, NZ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Auckland, Auckland, Auckland, NZ","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":null,"apc_paid":null,"fwci":1.5422,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.83200245,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2015","issue":null,"first_page":"7341","last_page":"7344"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14126","display_name":"Intramuscular injections and effects","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampoule","display_name":"Ampoule","score":0.9692314863204956},{"id":"https://openalex.org/keywords/injector","display_name":"Injector","score":0.8046197891235352},{"id":"https://openalex.org/keywords/piston","display_name":"Piston (optics)","score":0.7391025424003601},{"id":"https://openalex.org/keywords/jet","display_name":"Jet (fluid)","score":0.6653172969818115},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.5729423761367798},{"id":"https://openalex.org/keywords/head","display_name":"Head (geology)","score":0.5000810623168945},{"id":"https://openalex.org/keywords/piston-pump","display_name":"Piston pump","score":0.48328855633735657},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.4298493266105652},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.3433327078819275},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3357306122779846},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.27629753947257996},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.16817262768745422},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.13685184717178345},{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.12790337204933167},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12699827551841736},{"id":"https://openalex.org/keywords/cylinder","display_name":"Cylinder","score":0.11086452007293701}],"concepts":[{"id":"https://openalex.org/C28845197","wikidata":"https://www.wikidata.org/wiki/Q477379","display_name":"Ampoule","level":2,"score":0.9692314863204956},{"id":"https://openalex.org/C135186712","wikidata":"https://www.wikidata.org/wiki/Q425705","display_name":"Injector","level":2,"score":0.8046197891235352},{"id":"https://openalex.org/C199524791","wikidata":"https://www.wikidata.org/wiki/Q7198512","display_name":"Piston (optics)","level":3,"score":0.7391025424003601},{"id":"https://openalex.org/C119947313","wikidata":"https://www.wikidata.org/wiki/Q5596635","display_name":"Jet (fluid)","level":2,"score":0.6653172969818115},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5729423761367798},{"id":"https://openalex.org/C2780312720","wikidata":"https://www.wikidata.org/wiki/Q5689100","display_name":"Head (geology)","level":2,"score":0.5000810623168945},{"id":"https://openalex.org/C83800877","wikidata":"https://www.wikidata.org/wiki/Q1038362","display_name":"Piston pump","level":3,"score":0.48328855633735657},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.4298493266105652},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.3433327078819275},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3357306122779846},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.27629753947257996},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.16817262768745422},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.13685184717178345},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.12790337204933167},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12699827551841736},{"id":"https://openalex.org/C203311528","wikidata":"https://www.wikidata.org/wiki/Q34132","display_name":"Cylinder","level":2,"score":0.11086452007293701},{"id":"https://openalex.org/C114793014","wikidata":"https://www.wikidata.org/wiki/Q52109","display_name":"Geomorphology","level":1,"score":0.0},{"id":"https://openalex.org/C165699331","wikidata":"https://www.wikidata.org/wiki/Q461533","display_name":"Wavefront","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004349","descriptor_name":"Drug Packaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004349","descriptor_name":"Drug Packaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004349","descriptor_name":"Drug Packaging","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007277","descriptor_name":"Injections, Jet","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D007277","descriptor_name":"Injections, Jet","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D007277","descriptor_name":"Injections, Jet","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009339","descriptor_name":"Needles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009339","descriptor_name":"Needles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009339","descriptor_name":"Needles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2015.7320087","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7320087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26737987","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26737987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:researchspace.auckland.ac.nz:2292/27608","is_oa":false,"landing_page_url":"http://hdl.handle.net/2292/27608","pdf_url":null,"source":{"id":"https://openalex.org/S7407055463","display_name":"ResearchSpace (University of Auckland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I154130895","host_organization_name":"University of Auckland","host_organization_lineage":["https://openalex.org/I154130895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Conference Item"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1984548348","https://openalex.org/W1997921324","https://openalex.org/W2030363631","https://openalex.org/W2037039648","https://openalex.org/W2047353849","https://openalex.org/W2049784788","https://openalex.org/W2058789310","https://openalex.org/W2075221397","https://openalex.org/W2085068888","https://openalex.org/W2332691715","https://openalex.org/W2479292935","https://openalex.org/W6702343503"],"related_works":["https://openalex.org/W2356301076","https://openalex.org/W2010911909","https://openalex.org/W2335873985","https://openalex.org/W2391132945","https://openalex.org/W3024666004","https://openalex.org/W2389290995","https://openalex.org/W2391100753","https://openalex.org/W4385079400","https://openalex.org/W4385080570","https://openalex.org/W2349811930"],"abstract_inverted_index":{"We":[0,76],"present":[1],"a":[2,6,46,68,82,96,116,136],"new":[3],"design":[4,53],"for":[5],"needle-free":[7,57],"injector":[8],"ampoule,":[9,84],"using":[10],"two":[11,109,124],"concentric":[12],"pistons":[13,125],"to":[14,27,40,55,63,131,135,142,153],"pressurize":[15],"the":[16,19,37,42,86,108,123,143,158,165],"fluid":[17,141,159],"during":[18],"injection.":[20],"The":[21,49,104,127],"smaller,":[22],"inner":[23],"piston":[24,39],"is":[25,54,129,151],"used":[26],"provide":[28],"an":[29,113],"initial":[30],"high-velocity":[31],"piercing":[32],"jet;":[33],"it":[34,89],"then":[35],"engages":[36],"outer":[38],"deliver":[41,140],"remaining":[43],"drug":[44],"via":[45],"low-velocity":[47],"jet.":[48],"goal":[50],"of":[51,59,98,112,119,157],"this":[52,78],"enable":[56],"delivery":[58],"relatively":[60],"large":[61],"volumes":[62],"controlled":[64,137],"depths":[65],"in":[66,91],"tissue,":[67],"task":[69],"impractical":[70],"with":[71,115],"conventional":[72],"ampoules":[73],"and":[74,94,139],"actuators.":[75],"demonstrate":[77],"concept":[79],"by":[80],"constructing":[81],"1.2mL":[83],"measuring":[85],"jet":[87,120],"velocity":[88,121],"produces":[90,107],"free":[92],"air,":[93],"performing":[95],"set":[97],"injections":[99],"into":[100],"post-mortem":[101],"porcine":[102,133],"tissue.":[103],"ampoule":[105],"smoothly":[106],"desired":[110,166],"phases":[111],"injection,":[114],"smooth":[117],"transition":[118],"as":[122],"engage.":[126],"injection":[128],"able":[130],"penetrate":[132],"skin":[134],"depth":[138],"subcutaneous":[144],"and/or":[145],"intramuscular":[146],"layers,":[147],"though":[148],"further":[149],"investigation":[150],"required":[152],"ensure":[154],"that":[155],"all":[156],"delivered":[160],"can":[161],"be":[162],"retained":[163],"at":[164],"depth.":[167]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
