{"id":"https://openalex.org/W2294911206","doi":"https://doi.org/10.1109/embc.2015.7319884","title":"Identifying gene subnetworks associated with clinical outcome in ovarian cancer using Network Based Coalition Game","display_name":"Identifying gene subnetworks associated with clinical outcome in ovarian cancer using Network Based Coalition Game","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2294911206","doi":"https://doi.org/10.1109/embc.2015.7319884","mag":"2294911206","pmid":"https://pubmed.ncbi.nlm.nih.gov/26737784"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7319884","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319884","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011987346","display_name":"Abolfazl Razi","orcid":"https://orcid.org/0000-0002-3330-6132"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Abolfazl Razi","raw_affiliation_strings":["Case Western Reserve University, Cleveland, OH, US"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University, Cleveland, OH, US","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035395012","display_name":"Fatemeh Afghah","orcid":"https://orcid.org/0000-0002-2315-1173"},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatemeh Afghah","raw_affiliation_strings":["ECE Department, North Carolina A&T State University, Greensboro, NC"],"affiliations":[{"raw_affiliation_string":"ECE Department, North Carolina A&T State University, Greensboro, NC","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005628876","display_name":"Vinay Varadan","orcid":"https://orcid.org/0000-0003-1520-1967"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vinay Varadan","raw_affiliation_strings":["Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH"],"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011987346"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":null,"apc_paid":null,"fwci":1.0211,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76776598,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"ii","issue":null,"first_page":"6509","last_page":"6513"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9632999897003174,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9524000287055969,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5976721048355103},{"id":"https://openalex.org/keywords/predictability","display_name":"Predictability","score":0.5620197057723999},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.4989352226257324},{"id":"https://openalex.org/keywords/predictive-power","display_name":"Predictive power","score":0.49447107315063477},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.49101924896240234},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.47206953167915344},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4638751745223999},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.44336411356925964},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.4318960905075073},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.43069350719451904},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3304075002670288},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.299399197101593},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18866142630577087},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1614055335521698},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1343514323234558}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5976721048355103},{"id":"https://openalex.org/C197640229","wikidata":"https://www.wikidata.org/wiki/Q2534066","display_name":"Predictability","level":2,"score":0.5620197057723999},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4989352226257324},{"id":"https://openalex.org/C2778136018","wikidata":"https://www.wikidata.org/wiki/Q10350689","display_name":"Predictive power","level":2,"score":0.49447107315063477},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49101924896240234},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.47206953167915344},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4638751745223999},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.44336411356925964},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.4318960905075073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43069350719451904},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3304075002670288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.299399197101593},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18866142630577087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1614055335521698},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1343514323234558},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7319884","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319884","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26737784","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26737784","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.47999998927116394,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W38206204","https://openalex.org/W1562353621","https://openalex.org/W1968904042","https://openalex.org/W2014116656","https://openalex.org/W2040524415","https://openalex.org/W2042619428","https://openalex.org/W2073111188","https://openalex.org/W2117513900","https://openalex.org/W2119387367","https://openalex.org/W2154947819","https://openalex.org/W2164877031","https://openalex.org/W6722226382"],"related_works":["https://openalex.org/W3122845461","https://openalex.org/W3125380173","https://openalex.org/W3124164994","https://openalex.org/W4388281457","https://openalex.org/W4285890971","https://openalex.org/W4400439062","https://openalex.org/W3125898096","https://openalex.org/W1568456066","https://openalex.org/W3122679999","https://openalex.org/W1990819141"],"abstract_inverted_index":{"The":[0],"problem":[1],"of":[2,18,27,34,40,80,97,113,125,162,177],"identifying":[3,178],"interacting":[4],"genes":[5,77,115],"that":[6,36,116,146,183],"jointly":[7,61],"are":[8,20,51,107],"associated":[9],"with":[10,100,123,173],"a":[11,68,81],"phenotype":[12],"is":[13,43,73],"considered.":[14],"When":[15],"the":[16,25,129,163,174,188],"number":[17,26],"features":[19,35],"extremely":[21],"large":[22],"compared":[23,167],"to":[24,60,132,142,154,168],"samples,":[28],"there":[29],"may":[30,184],"be":[31],"several":[32],"subsets":[33],"provide":[37,185],"acceptable":[38],"levels":[39],"predictability.":[41],"This":[42,84],"particularly":[44],"true":[45],"in":[46,53,121,140,152],"cancer":[47,63,98,135,149,191],"genomics,":[48],"where":[49],"we":[50],"interested":[52],"finding":[54],"functionally":[55],"related":[56],"gene":[57,90,94,181],"sets":[58],"likely":[59],"drive":[62],"phenotypes.":[64],"In":[65],"this":[66],"paper,":[67],"novel":[69],"game":[70],"theoretic":[71],"solution":[72],"proposed":[74,130,164],"by":[75,92,110],"modeling":[76],"as":[78],"players":[79],"Coalition":[82],"Game.":[83],"method":[85,165],"discovers":[86],"and":[87],"develops":[88],"informative":[89],"subnetworks":[91,106,124,145,182],"integrating":[93],"expression":[95],"profiling":[96],"tissues":[99],"protein-protein":[101],"interaction":[102],"(PPI)":[103],"networks.":[104],"These":[105],"gradually":[108],"developed":[109],"selective":[111],"addition":[112],"candidate":[114],"present":[117],"maximal":[118],"Shapely":[119],"values":[120],"coalition":[122],"genes.":[126],"We":[127,157],"applied":[128],"algorithm":[131],"an":[133],"ovarian":[134],"dataset":[136],"(N":[137],"=":[138],"201),":[139],"order":[141],"identify":[143],"optimal":[144],"can":[147],"predict":[148],"progression":[150],"risk":[151],"response":[153],"platinum-based":[155],"therapy.":[156],"show":[158],"improved":[159],"predictive":[160],"power":[161],"when":[166],"state-of-the-art":[169],"feature":[170],"selection":[171],"methods,":[172],"added":[175],"advantage":[176],"potentially":[179],"functional":[180],"insights":[186],"into":[187],"mechanisms":[189],"underlying":[190],"progression.":[192]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}