{"id":"https://openalex.org/W2227371161","doi":"https://doi.org/10.1109/embc.2015.7319381","title":"A machine learning pipeline for multiple sclerosis course detection from clinical scales and patient reported outcomes","display_name":"A machine learning pipeline for multiple sclerosis course detection from clinical scales and patient reported outcomes","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2227371161","doi":"https://doi.org/10.1109/embc.2015.7319381","mag":"2227371161","pmid":"https://pubmed.ncbi.nlm.nih.gov/26737281"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7319381","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319381","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085857867","display_name":"Samuele Fiorini","orcid":"https://orcid.org/0000-0001-9162-5767"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Samuele Fiorini","raw_affiliation_strings":["DIBRIS, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIBRIS, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036620304","display_name":"Alessandro Verri","orcid":"https://orcid.org/0000-0001-9777-9986"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Verri","raw_affiliation_strings":["DIBRIS, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIBRIS, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004012873","display_name":"Andrea Tacchino","orcid":"https://orcid.org/0000-0002-2263-7315"},"institutions":[{"id":"https://openalex.org/I2799371350","display_name":"Multiple Sclerosis Foundation","ror":"https://ror.org/049fh2r80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799371350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Tacchino","raw_affiliation_strings":["Scientific Research Area, Italian MS Foundation, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Area, Italian MS Foundation, Genoa, Italy","institution_ids":["https://openalex.org/I2799371350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043401308","display_name":"Michela Ponzio","orcid":"https://orcid.org/0000-0001-5245-0474"},"institutions":[{"id":"https://openalex.org/I2799371350","display_name":"Multiple Sclerosis Foundation","ror":"https://ror.org/049fh2r80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799371350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michela Ponzio","raw_affiliation_strings":["Scientific Research Area, Italian MS Foundation, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Area, Italian MS Foundation, Genoa, Italy","institution_ids":["https://openalex.org/I2799371350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016510324","display_name":"Giampaolo Brichetto","orcid":"https://orcid.org/0000-0003-2026-3572"},"institutions":[{"id":"https://openalex.org/I2799371350","display_name":"Multiple Sclerosis Foundation","ror":"https://ror.org/049fh2r80","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799371350"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giampaolo Brichetto","raw_affiliation_strings":["Scientific Research Area, Italian MS Foundation, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scientific Research Area, Italian MS Foundation, Genoa, Italy","institution_ids":["https://openalex.org/I2799371350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003964675","display_name":"Annalisa Barla","orcid":"https://orcid.org/0000-0002-3436-035X"},"institutions":[{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Barla","raw_affiliation_strings":["DIBRIS, University of Genoa, Genoa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"DIBRIS, University of Genoa, Genoa, Italy","institution_ids":["https://openalex.org/I83816512"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8853,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.74833731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2015","issue":null,"first_page":"4443","last_page":"4446"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.9713000059127808,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9595999717712402,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"Multiple sclerosis","score":0.6891705989837646},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6011514067649841},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5498179197311401},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5398738384246826},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.5386818051338196},{"id":"https://openalex.org/keywords/data-collection","display_name":"Data collection","score":0.45901811122894287},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4254005551338196},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"Quality of life (healthcare)","score":0.42512714862823486},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3583473563194275},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.11038166284561157}],"concepts":[{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.6891705989837646},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6011514067649841},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5498179197311401},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5398738384246826},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5386818051338196},{"id":"https://openalex.org/C133462117","wikidata":"https://www.wikidata.org/wiki/Q4929239","display_name":"Data collection","level":2,"score":0.45901811122894287},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4254005551338196},{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.42512714862823486},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3583473563194275},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.11038166284561157},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071066","descriptor_name":"Patient Reported Outcome Measures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2015.7319381","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319381","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26737281","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26737281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:iris.unige.it:11567/861619","is_oa":false,"landing_page_url":"http://hdl.handle.net/11567/861619","pdf_url":null,"source":{"id":"https://openalex.org/S4377196291","display_name":"CINECA IRIS Institutial Research Information System (University of Genoa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I83816512","host_organization_name":"University of Genoa","host_organization_lineage":["https://openalex.org/I83816512"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1480400193","https://openalex.org/W1999132491","https://openalex.org/W2026205014","https://openalex.org/W2038897113","https://openalex.org/W2049864839","https://openalex.org/W2060934370","https://openalex.org/W2084911874","https://openalex.org/W2087589796","https://openalex.org/W2101234009","https://openalex.org/W2114728329","https://openalex.org/W2120265437","https://openalex.org/W2128114973","https://openalex.org/W2168899164","https://openalex.org/W2324578271","https://openalex.org/W2787894218","https://openalex.org/W6628657050","https://openalex.org/W6660020787","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2617222556","https://openalex.org/W2961085424","https://openalex.org/W4306674287","https://openalex.org/W4224009465","https://openalex.org/W4286629047","https://openalex.org/W4293525103","https://openalex.org/W3200179079","https://openalex.org/W3087493185"],"abstract_inverted_index":{"In":[0],"this":[1],"work":[2],"we":[3],"present":[4],"a":[5,17,37,41],"machine":[6],"learning":[7,91],"pipeline":[8],"for":[9],"the":[10,76],"detection":[11],"of":[12,19,67,78],"multiple":[13,49],"sclerosis":[14],"course":[15,101],"from":[16,40,86],"collection":[18],"inexpensive":[20],"and":[21,28,65,100,109],"non-invasive":[22],"measures":[23],"such":[24],"as":[25,81],"clinical":[26,42,88,107],"scales":[27,108],"patient-reported":[29,110],"outcomes.":[30],"The":[31,51],"proposed":[32],"analysis":[33],"is":[34],"conducted":[35],"on":[36],"dataset":[38],"coming":[39],"study":[43],"comprising":[44],"457":[45],"patients":[46,56,79],"affected":[47],"by":[48],"sclerosis.":[50],"91":[52],"collected":[53],"variables":[54],"describe":[55],"mobility,":[57],"fatigue,":[58],"cognitive":[59],"performance,":[60],"emotional":[61],"status,":[62],"bladder":[63],"continence":[64],"quality":[66],"life.":[68],"A":[69],"preliminary":[70],"data":[71],"exploration":[72],"phase":[73],"suggests":[74],"that":[75,106],"group":[77],"diagnosed":[80],"Relapsing-Remitting":[82,117],"can":[83,112],"be":[84,113],"isolated":[85],"other":[87],"courses.":[89],"Supervised":[90],"algorithms":[92],"are":[93],"then":[94],"applied":[95],"to":[96,115],"perform":[97],"feature":[98],"selection":[99],"classification.":[102],"Our":[103],"results":[104],"confirm":[105],"outcomes":[111],"used":[114],"classify":[116],"patients.":[118]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}