{"id":"https://openalex.org/W2296310219","doi":"https://doi.org/10.1109/embc.2015.7319251","title":"A simulation study on marrow fat effect on biomechanics of vertebra bone","display_name":"A simulation study on marrow fat effect on biomechanics of vertebra bone","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2296310219","doi":"https://doi.org/10.1109/embc.2015.7319251","mag":"2296310219","pmid":"https://pubmed.ncbi.nlm.nih.gov/26737151"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7319251","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319251","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100350405","display_name":"Yang Chen","orcid":"https://orcid.org/0000-0002-1555-1871"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Chen","raw_affiliation_strings":["Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009763761","display_name":"T. Heather","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather T. Ma","raw_affiliation_strings":["Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420704","display_name":"Liang Li","orcid":"https://orcid.org/0000-0003-0745-2571"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Liang","raw_affiliation_strings":["Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100603442","display_name":"Chaoyang Zhang","orcid":"https://orcid.org/0000-0001-6816-3840"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaoyang Zhang","raw_affiliation_strings":["Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic & Information Engineering, Shenzhen Graduate School, Shenzhen, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048000096","display_name":"James F. Griffith","orcid":"https://orcid.org/0000-0001-5206-9382"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"James F. Griffith","raw_affiliation_strings":["Chinese University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009913628","display_name":"Ping\u2010Chung Leung","orcid":"https://orcid.org/0000-0002-0195-4688"},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Ping-Chung Leung","raw_affiliation_strings":["Chinese University of Hong Kong, Hong Kong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese University of Hong Kong, Hong Kong, China","institution_ids":["https://openalex.org/I177725633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"59","issue":null,"first_page":"3921","last_page":"3924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12209","display_name":"Bone and Joint Diseases","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11218","display_name":"Hip disorders and treatments","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomechanics","display_name":"Biomechanics","score":0.7525612115859985},{"id":"https://openalex.org/keywords/cancellous-bone","display_name":"Cancellous bone","score":0.73703932762146},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"Bone marrow","score":0.6823761463165283},{"id":"https://openalex.org/keywords/vertebra","display_name":"Vertebra","score":0.6005823612213135},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.49566590785980225},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"Osteoporosis","score":0.4312410056591034},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3947957754135132},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3910121023654938},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29045581817626953},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.22273743152618408}],"concepts":[{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.7525612115859985},{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.73703932762146},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6823761463165283},{"id":"https://openalex.org/C2776412215","wikidata":"https://www.wikidata.org/wiki/Q180323","display_name":"Vertebra","level":2,"score":0.6005823612213135},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.49566590785980225},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.4312410056591034},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3947957754135132},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3910121023654938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29045581817626953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22273743152618408}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008159","descriptor_name":"Lumbar Vertebrae","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020342","descriptor_name":"Finite Element Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055595","descriptor_name":"Mechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055595","descriptor_name":"Mechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055595","descriptor_name":"Mechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7319251","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7319251","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26737151","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26737151","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.8999999761581421,"id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1901463649","https://openalex.org/W1979850569","https://openalex.org/W1986585266","https://openalex.org/W1987176983","https://openalex.org/W1993090130","https://openalex.org/W1994558133","https://openalex.org/W2007227307","https://openalex.org/W2010751506","https://openalex.org/W2020300493","https://openalex.org/W2022304176","https://openalex.org/W2028296377","https://openalex.org/W2029097920","https://openalex.org/W2045789765","https://openalex.org/W2050648187","https://openalex.org/W2056885783","https://openalex.org/W2058327392","https://openalex.org/W2089611441","https://openalex.org/W2095150495","https://openalex.org/W2113697838","https://openalex.org/W2122835632","https://openalex.org/W2165133146","https://openalex.org/W2319992238","https://openalex.org/W4206290900","https://openalex.org/W4298050044"],"related_works":["https://openalex.org/W3014307317","https://openalex.org/W2668228314","https://openalex.org/W1964839588","https://openalex.org/W1838018750","https://openalex.org/W1537355970","https://openalex.org/W2416744797","https://openalex.org/W581996473","https://openalex.org/W2183559900","https://openalex.org/W2079819610","https://openalex.org/W2941259678"],"abstract_inverted_index":{"Trabecular":[0],"bone":[1,3,15,23,27,44,51,135,154,164,169],"and":[2,69,180],"marrow":[4,24,39,71,99,138,148,181],"are":[5],"main":[6],"components":[7],"of":[8,89,133,162,177],"cancellous":[9],"bone.":[10],"Most":[11],"mechanical":[12],"studies":[13],"for":[14],"mainly":[16],"focus":[17],"on":[18,42,56,81],"hard":[19],"tissues,":[20],"while":[21],"if":[22],"contributes":[25],"to":[26,37,86,152],"biomechanics":[28,45],"is":[29],"not":[30],"clear":[31],"yet.":[32],"This":[33],"study":[34],"was":[35,79,120],"proposed":[36,83],"investigate":[38],"fat":[40,72,100,139,149,182],"effect":[41],"trabecular":[43,66,95,178],"by":[46],"simulation.":[47],"Finite":[48],"element":[49],"(FE)":[50],"models":[52,84,96,110],"were":[53,73],"established":[54],"based":[55],"quantitative":[57],"CT":[58],"images":[59],"at":[60],"L3":[61],"lumbar":[62],"spine,":[63],"from":[64],"which":[65,166],"structures":[67],"with":[68,98,111,126,137],"without":[70],"investigated":[74],"respectively.":[75],"Auni-static":[76],"compressive":[77,173],"test":[78],"applied":[80],"the":[82,87,134,153,159,163,190],"until":[85],"appearance":[88],"fracture.":[90],"Simulation":[91],"results":[92],"showed":[93,140],"that":[94],"filled":[97],"had":[101],"about":[102,121],"3%-9%":[103],"less":[104],"maximum":[105],"stress":[106,117,160],"in":[107,118],"volume":[108,119],"than":[109,124],"only":[112,127],"trabeculae.":[113,128],"However,":[114],"its":[115],"average":[116],"9%-56%":[122],"larger":[123],"those":[125],"The":[129,175],"strain":[130],"energy":[131],"density":[132],"model":[136],"a":[141,146,172],"more":[142],"uniformed":[143],"distribution.":[144],"As":[145],"conclusion,":[147],"has":[150],"contributions":[151],"mechanics.":[155],"It":[156],"can":[157],"balance":[158],"distribution":[161],"tissue,":[165],"may":[167],"reduce":[168],"deformation":[170],"under":[171],"loading.":[174],"mixture":[176],"structure":[179],"would":[183],"be":[184],"against":[185],"higher":[186],"compress":[187],"load":[188],"before":[189],"failure":[191],"point.":[192]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}