{"id":"https://openalex.org/W2296304679","doi":"https://doi.org/10.1109/embc.2015.7318623","title":"Active induction of in vivo microbubbles by acoustic radiation force at the bifurcation of blood vessel and its evaluation","display_name":"Active induction of in vivo microbubbles by acoustic radiation force at the bifurcation of blood vessel and its evaluation","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2296304679","doi":"https://doi.org/10.1109/embc.2015.7318623","mag":"2296304679","pmid":"https://pubmed.ncbi.nlm.nih.gov/26736523"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7318623","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018494644","display_name":"Kohji Masuda","orcid":"https://orcid.org/0000-0003-2991-0385"},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kohji Masuda","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044034017","display_name":"Jun Koido","orcid":null},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Koido","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003452851","display_name":"Shinya Miyazawa","orcid":null},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shinya Miyazawa","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101016035","display_name":"Hikaru Wada","orcid":null},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hikaru Wada","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030515186","display_name":"Naoto Hosaka","orcid":null},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naoto Hosaka","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090323792","display_name":"Takashi Mochizuki","orcid":"https://orcid.org/0000-0002-3793-980X"},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Mochizuki","raw_affiliation_strings":["Tokyo University of Agriculture and Technology, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Tokyo University of Agriculture and Technology, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5018494644"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":null,"apc_paid":null,"fwci":0.8851,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74836812,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"50","issue":null,"first_page":"1369","last_page":"1372"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11842","display_name":"Ultrasound and Cavitation Phenomena","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microbubbles","display_name":"Microbubbles","score":0.9844837188720703},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.744861364364624},{"id":"https://openalex.org/keywords/acoustic-radiation-force","display_name":"Acoustic radiation force","score":0.6998741626739502},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.6063793897628784},{"id":"https://openalex.org/keywords/ultrasound","display_name":"Ultrasound","score":0.5876840353012085},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.583342432975769},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.5159895420074463},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.45025503635406494},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.21593612432479858},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1388719081878662},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.13281786441802979},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.08099189400672913},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07143685221672058}],"concepts":[{"id":"https://openalex.org/C64012434","wikidata":"https://www.wikidata.org/wiki/Q6839290","display_name":"Microbubbles","level":3,"score":0.9844837188720703},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.744861364364624},{"id":"https://openalex.org/C2781325599","wikidata":"https://www.wikidata.org/wiki/Q4674704","display_name":"Acoustic radiation force","level":3,"score":0.6998741626739502},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6063793897628784},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5876840353012085},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.583342432975769},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5159895420074463},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.45025503635406494},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.21593612432479858},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1388719081878662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13281786441802979},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.08099189400672913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07143685221672058},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013016","descriptor_name":"Sound","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013016","descriptor_name":"Sound","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013016","descriptor_name":"Sound","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045423","descriptor_name":"Microbubbles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7318623","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318623","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26736523","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26736523","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7699999809265137,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W273374358","https://openalex.org/W1998506271","https://openalex.org/W2015910123","https://openalex.org/W2030314489","https://openalex.org/W2035244308","https://openalex.org/W2043055195","https://openalex.org/W2046573389","https://openalex.org/W2063507890","https://openalex.org/W2065902356","https://openalex.org/W2084054905"],"related_works":["https://openalex.org/W2143941942","https://openalex.org/W2028815274","https://openalex.org/W4239893214","https://openalex.org/W2421589566","https://openalex.org/W2358663732","https://openalex.org/W2901237116","https://openalex.org/W2077916659","https://openalex.org/W2146341506","https://openalex.org/W2995929104","https://openalex.org/W2027618168"],"abstract_inverted_index":{"Alhough":[0],"the":[1,29,44,78,87,91,127,149,178,188,191,193,197,208,214],"development":[2],"of":[3,28,43,68,107,110,116,130,135,142,154,168,174,190],"drug":[4],"delivery":[5],"system":[6],"using":[7],"microbubbles":[8,14,30,54,84,111,157,194],"and":[9,83,138],"ultrasound":[10],"is":[11,185],"expected,":[12],"because":[13,62,177],"diffuse":[15],"in":[16,31,37,52,59,69,86,94,99,112,155,161,171,181,196,207,217],"bloodstream,":[17],"we":[18,75,103,147],"have":[19,76],"so":[20],"far":[21],"reported":[22],"our":[23],"attempts":[24],"for":[25,66,151],"active":[26,108,152],"control":[27],"flow":[32,133],"by":[33],"acoustic":[34],"radiation":[35],"force":[36],"order":[38],"to":[39,89,158],"increase":[40],"local":[41],"concentration":[42,85,93,195],"microbubbles.":[45],"However,":[46],"there":[47,63],"was":[48,200],"no":[49],"evidence":[50],"that":[51,206],"vivo":[53,70,100,156],"act":[55],"as":[56,58],"similar":[57],"vitro":[60,162,218],"experiments,":[61],"were":[64,123],"limitations":[65],"reproduction":[67],"conditions.":[71],"In":[72],"this":[73],"study,":[74],"elucidated":[77],"relationship":[79],"between":[80],"brightness":[81],"variation":[82],"suspension":[88],"estimate":[90],"absolute":[92],"an":[95,105,172],"invisible":[96],"condition":[97],"considering":[98],"experiment.":[101],"Then":[102,146],"conducted":[104],"experiment":[106],"induction":[109,153],"a":[113,166,175],"Y-form":[114],"bifurcation":[115,167,179],"artificial":[117],"blood":[118,169,183],"vessel,":[119],"where":[120],"experimental":[121],"conditions":[122,150],"with":[124,160,213],"focused":[125],"ultrasound,":[126],"central":[128],"frequency":[129],"5":[131],"MHz,":[132],"velocity":[134],"30":[136],"mm/s,":[137],"maximum":[139],"sound":[140],"pressure":[141],"300":[143],"kPa-pp,":[144],"respectively.":[145],"applied":[148],"compare":[159],"experiments.":[163,219],"We":[164],"used":[165],"vessel":[170,184],"ear":[173],"rabbit":[176],"shape":[180],"its":[182],"visible.":[186],"As":[187],"results":[189,215],"experiment,":[192],"induced":[198],"path":[199],"almost":[201],"two":[202],"times":[203],"higher":[204],"than":[205],"other":[209],"path,":[210],"which":[211],"agrees":[212],"from":[216]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
