{"id":"https://openalex.org/W2296498874","doi":"https://doi.org/10.1109/embc.2015.7318595","title":"Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay","display_name":"Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2296498874","doi":"https://doi.org/10.1109/embc.2015.7318595","mag":"2296498874","pmid":"https://pubmed.ncbi.nlm.nih.gov/26736495"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7318595","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://zenodo.org/record/1267998","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109325667","display_name":"Lorenzo Valerio","orcid":null},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]},{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lorenzo Valerio","raw_affiliation_strings":["Cardiothoracic ICU in San Raffaele Hospital, Coagulation service - thrombosis research Lab, Milano, Italy","Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Cardiothoracic ICU in San Raffaele Hospital, Coagulation service - thrombosis research Lab, Milano, Italy","institution_ids":["https://openalex.org/I154387261"]},{"raw_affiliation_string":"Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012683951","display_name":"Filippo Consolo","orcid":"https://orcid.org/0000-0002-7948-3847"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Consolo","raw_affiliation_strings":["Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051249259","display_name":"Danny Bluestein","orcid":"https://orcid.org/0000-0002-4014-2308"},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danny Bluestein","raw_affiliation_strings":["Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034094116","display_name":"Phat Tran","orcid":"https://orcid.org/0000-0003-3438-5829"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phat Tran","raw_affiliation_strings":["Sarver Heart Center, University of Arizona, Tucson, Arizona, USA"],"affiliations":[{"raw_affiliation_string":"Sarver Heart Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070730048","display_name":"Marvin J. Slepian","orcid":"https://orcid.org/0000-0002-7864-6691"},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marvin Slepian","raw_affiliation_strings":["Sarver Heart Center, University of Arizona, Tucson, Arizona, USA"],"affiliations":[{"raw_affiliation_string":"Sarver Heart Center, University of Arizona, Tucson, Arizona, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081695706","display_name":"Alberto Redaelli","orcid":"https://orcid.org/0000-0002-9020-2188"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Redaelli","raw_affiliation_strings":["Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Electronics Information and Bioengineering (DEIB), Politecnico di Milano, Milano, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044743374","display_name":"Federico Pappalardo","orcid":"https://orcid.org/0000-0001-9129-833X"},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Federico Pappalardo","raw_affiliation_strings":["Cardiothoracic ICU in San Raffaele Hospital, Milano, Italy"],"affiliations":[{"raw_affiliation_string":"Cardiothoracic ICU in San Raffaele Hospital, Milano, Italy","institution_ids":["https://openalex.org/I154387261"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5109325667"],"corresponding_institution_ids":["https://openalex.org/I154387261","https://openalex.org/I93860229"],"apc_list":null,"apc_paid":null,"fwci":1.144,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77991094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"34","issue":null,"first_page":"1255","last_page":"1258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10675","display_name":"Mechanical Circulatory Support Devices","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet","display_name":"Platelet","score":0.6872429251670837},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"Platelet activation","score":0.5443957448005676},{"id":"https://openalex.org/keywords/shear","display_name":"Shear (geology)","score":0.5327560901641846},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.392845094203949},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33142733573913574},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2740325331687927},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.20095780491828918}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6872429251670837},{"id":"https://openalex.org/C3018697912","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Platelet activation","level":3,"score":0.5443957448005676},{"id":"https://openalex.org/C96035792","wikidata":"https://www.wikidata.org/wiki/Q43606218","display_name":"Shear (geology)","level":2,"score":0.5327560901641846},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.392845094203949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33142733573913574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2740325331687927},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.20095780491828918}],"mesh":[{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006353","descriptor_name":"Heart-Assist Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006461","descriptor_name":"Hemolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015539","descriptor_name":"Platelet Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2015.7318595","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318595","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26736495","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26736495","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:re.public.polimi.it:11311/984942","is_oa":false,"landing_page_url":"http://hdl.handle.net/11311/984942","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:zenodo.org:1267998","is_oa":true,"landing_page_url":"https://zenodo.org/record/1267998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferencePaper"}],"best_oa_location":{"id":"pmh:oai:zenodo.org:1267998","is_oa":true,"landing_page_url":"https://zenodo.org/record/1267998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferencePaper"},"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.4000000059604645}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1968334304","https://openalex.org/W1985504191","https://openalex.org/W1994494585","https://openalex.org/W2034437911","https://openalex.org/W2036553170","https://openalex.org/W2054265385","https://openalex.org/W2126966176","https://openalex.org/W2137719165","https://openalex.org/W2146155186","https://openalex.org/W2156469127","https://openalex.org/W2160616952","https://openalex.org/W2344022727","https://openalex.org/W2403730386","https://openalex.org/W2493086572","https://openalex.org/W6713190468"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W4302324012","https://openalex.org/W4248554551","https://openalex.org/W1988467799","https://openalex.org/W4315754442","https://openalex.org/W1967892882","https://openalex.org/W2062077711"],"abstract_inverted_index":{"Left":[0],"ventricular":[1],"assist":[2],"devices":[3],"(LVADs)":[4],"have":[5],"emerged":[6],"as":[7,92,104,151],"vital":[8],"life-saving":[9],"therapeutic":[10],"systems":[11,25],"for":[12,95,202],"patients":[13,204],"with":[14],"advanced":[15],"and":[16,136,142,225,244],"end-stage":[17],"heart":[18],"failure":[19],"(HF).":[20],"Despite":[21],"their":[22],"efficacy,":[23],"VAD":[24,61],"remain":[26],"limited":[27,101],"by":[28],"post-implantation":[29],"thrombotic":[30],"complications.":[31],"Shear-mediated":[32],"platelet":[33,47,58,71,74,97,124,171,214,249],"activation":[34,59,125,172,215],"is":[35,78,241],"the":[36,55,106,112,116,128,161,187,238,257,264],"major":[37,193],"driver":[38],"of":[39,57,108,133,166,170,192,208,213,247,259,266],"such":[40],"complications":[41],"in":[42,53,60,87,111,173,176,186,195,223,263],"these":[43],"devices.":[44],"Nowadays":[45],"few":[46],"function":[48],"assays":[49,65],"are":[50],"routinely":[51],"utilized":[52],"assessing":[54],"degree":[56],"implanted":[62,268],"patients.":[63,269],"No":[64],"exist":[66,103],"that":[67,82,160,237],"specifically":[68],"target":[69],"shear-mediated":[70,96,248],"activation.":[72,98,250],"The":[73],"activity":[75],"state":[76],"(PAS)":[77],"a":[79,93,242],"novel":[80],"assay":[81,110,163,240,262],"has":[83],"been":[84],"well":[85],"validated":[86],"vitro,":[88],"measuring":[89],"thrombin":[90],"release":[91],"surrogate":[94],"To":[99],"date":[100],"data":[102],"to":[105,152],"utility":[107],"this":[109,260],"clinical":[113],"setting.":[114],"In":[115],"present":[117],"study":[118],"we":[119],"evaluated":[120],"eight":[121],"LVAD":[122,267],"patients'":[123,252],"level":[126,169,212],"using":[127],"PAS":[129,162,219,239],"assay.":[130],"Simultaneous":[131],"measurements":[132],"conventional":[134],"prothrombotic":[135],"hemolysis":[137],"markers,":[138],"-":[139,146],"i.e.":[140],"fibrinogen":[141,196,224],"lactate":[143],"dehydrogenase":[144],"(LDH)":[145],"were":[147,156,206,227],"also":[148],"performed.":[149],"Trends":[150],"alteration":[153],"from":[154,181,231],"baseline":[155],"studied.":[157],"We":[158],"observed":[159],"allowed":[164],"detection":[165],"an":[167,182],"abnormal":[168],"one":[174],"patient":[175,189],"our":[177,232],"series":[178,234],"who":[179,205],"suffered":[180],"overt":[183],"thrombosis.":[184],"Interestingly":[185],"same":[188],"no":[190,210],"signal":[191],"abnormality":[194],"or":[197],"LDH":[198,226],"was":[199,216],"detected.":[200],"Further":[201,251],"7/8":[203],"free":[207],"thrombosis,":[209],"significant":[211],"detected":[217],"via":[218],"assay,":[220],"while":[221],"elevation":[222],"observed.":[228],"As":[229],"such,":[230],"observational":[233],"it":[235],"appears":[236],"sensitive":[243],"specific":[245],"indicator":[246],"experience":[253],"will":[254],"help":[255],"elucidate":[256],"role":[258],"promising":[261],"management":[265]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
