{"id":"https://openalex.org/W2295807570","doi":"https://doi.org/10.1109/embc.2015.7318368","title":"Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system","display_name":"Modeling the Blood-Brain Barrier in a 3D triple co-culture microfluidic system","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2295807570","doi":"https://doi.org/10.1109/embc.2015.7318368","mag":"2295807570","pmid":"https://pubmed.ncbi.nlm.nih.gov/26736268"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7318368","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091486825","display_name":"Giulia Adriani","orcid":"https://orcid.org/0000-0002-7505-1668"},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"G. Adriani","raw_affiliation_strings":["BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057356324","display_name":"Dongliang Ma","orcid":"https://orcid.org/0000-0003-3077-1968"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"D. Ma","raw_affiliation_strings":["Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059891753","display_name":"Andrea Pavesi","orcid":"https://orcid.org/0000-0003-2777-1043"},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"A. Pavesi","raw_affiliation_strings":["BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore","institution_ids":["https://openalex.org/I4210167254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011054045","display_name":"Eyleen L. K. Goh","orcid":"https://orcid.org/0000-0002-8244-6959"},"institutions":[{"id":"https://openalex.org/I4210126319","display_name":"Duke-NUS Medical School","ror":"https://ror.org/02j1m6098","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I170897317","https://openalex.org/I4210126319"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"E. L. K. Goh","raw_affiliation_strings":["Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Programme in Neuroscience and Behavioral Disorders, Duke-NUS Graduate Medical School, Singapore","institution_ids":["https://openalex.org/I4210126319"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111405075","display_name":"Roger D. Kamm","orcid":"https://orcid.org/0000-0002-7232-304X"},"institutions":[{"id":"https://openalex.org/I4210167254","display_name":"Singapore-MIT Alliance for Research and Technology","ror":"https://ror.org/05yb3w112","country_code":"SG","type":"education","lineage":["https://openalex.org/I4210167254"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"R. D. Kamm","raw_affiliation_strings":["BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore","Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioSystems and Micromechanics IRG, Singapore-MIT Alliance for Research and Technology, Singapore","institution_ids":["https://openalex.org/I4210167254"]},{"raw_affiliation_string":"Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2015","issue":null,"first_page":"338","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blood\u2013brain-barrier","display_name":"Blood\u2013brain barrier","score":0.7978330850601196},{"id":"https://openalex.org/keywords/immunostaining","display_name":"Immunostaining","score":0.7065800428390503},{"id":"https://openalex.org/keywords/tight-junction","display_name":"Tight junction","score":0.6528062224388123},{"id":"https://openalex.org/keywords/umbilical-vein","display_name":"Umbilical vein","score":0.5997596383094788},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.557162344455719},{"id":"https://openalex.org/keywords/calcium-in-biology","display_name":"Calcium in biology","score":0.5345871448516846},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5297597050666809},{"id":"https://openalex.org/keywords/permeability","display_name":"Permeability (electromagnetism)","score":0.48321378231048584},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.47229698300361633},{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.4583546221256256},{"id":"https://openalex.org/keywords/barrier-function","display_name":"Barrier function","score":0.4576912820339203},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4496855139732361},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.438468873500824},{"id":"https://openalex.org/keywords/cell-culture","display_name":"Cell culture","score":0.419129878282547},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"Calcium imaging","score":0.4122433662414551},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.41164594888687134},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.39568158984184265},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.39494478702545166},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.32800835371017456},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.2947021722793579},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.23142486810684204},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.21499237418174744},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.19646435976028442},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16834202408790588},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16763758659362793},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"Immunohistochemistry","score":0.1455346643924713},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.08620962500572205}],"concepts":[{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.7978330850601196},{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.7065800428390503},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.6528062224388123},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.5997596383094788},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.557162344455719},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5345871448516846},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5297597050666809},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.48321378231048584},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.47229698300361633},{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.4583546221256256},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4576912820339203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4496855139732361},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.438468873500824},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.419129878282547},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.4122433662414551},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.41164594888687134},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39568158984184265},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39494478702545166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32800835371017456},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.2947021722793579},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.23142486810684204},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21499237418174744},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.19646435976028442},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16834202408790588},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16763758659362793},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1455346643924713},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08620962500572205},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010539","descriptor_name":"Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056656","descriptor_name":"Lab-On-A-Chip Devices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7318368","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318368","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26736268","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26736268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310422","display_name":"Emergent Behaviors of Integrated Cellular Systems","ror":"https://ror.org/00nxxkd60"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1751672930","https://openalex.org/W1994504773","https://openalex.org/W1994812037","https://openalex.org/W2010915890","https://openalex.org/W2037632846","https://openalex.org/W2052474126","https://openalex.org/W2061463538","https://openalex.org/W2074073922","https://openalex.org/W2085754209","https://openalex.org/W2088004044","https://openalex.org/W2110518736","https://openalex.org/W2116492181","https://openalex.org/W2124628016","https://openalex.org/W2139949808","https://openalex.org/W2159821105"],"related_works":["https://openalex.org/W2356872707","https://openalex.org/W2415302615","https://openalex.org/W2009081910","https://openalex.org/W2100308259","https://openalex.org/W2169260070","https://openalex.org/W2382424549","https://openalex.org/W2026729475","https://openalex.org/W4238991395","https://openalex.org/W1985517896","https://openalex.org/W2295807570"],"abstract_inverted_index":{"The":[0,94],"need":[1],"for":[2],"a":[3,54,101],"blood-brain":[4],"barrier":[5],"(BBB)":[6],"model":[7,32],"that":[8,46],"accurately":[9],"mimics":[10],"the":[11,15,44,49,76,91],"physiological":[12],"characteristics":[13],"of":[14,35,82,106],"in-vivo":[16],"situation":[17],"is":[18,28],"well-recognized":[19],"by":[20,41,100,115],"researchers":[21],"in":[22,90],"academia":[23],"and":[24,72],"industry.":[25],"However,":[26],"there":[27],"currently":[29],"no":[30],"in-vitro":[31],"allowing":[33],"studies":[34],"neuronal":[36],"growth":[37],"and/or":[38],"function":[39],"influenced":[40],"factors":[42],"from":[43],"blood":[45],"cross":[47],"through":[48],"BBB.":[50],"Therefore,":[51],"we":[52],"established":[53],"3D":[55],"triple":[56,78],"co-culture":[57,79],"microfluidic":[58],"system":[59,80],"using":[60,104],"human":[61],"umbilical":[62],"vein":[63],"endothelial":[64,92],"cells":[65],"(HUVEC)":[66],"together":[67],"with":[68,86],"primary":[69],"rat":[70],"astrocytes":[71],"neurons.":[73],"Immunostaining":[74],"confirmed":[75],"successful":[77],"consisting":[81],"an":[83],"intact":[84],"BBB":[85,95],"tight":[87],"intercellular":[88],"junctions":[89],"monolayer.":[93],"selective":[96],"permeability":[97],"was":[98,113],"determined":[99],"fluorescent-based":[102],"assay":[103],"dextrans":[105],"different":[107],"molecular":[108],"weights.":[109],"Finally,":[110],"neuron":[111],"functionality":[112],"demonstrated":[114],"calcium":[116],"imaging.":[117]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
