{"id":"https://openalex.org/W2224253494","doi":"https://doi.org/10.1109/embc.2015.7318293","title":"Modelling the effect of thickness on the electromechanical properties of in vitro cardiac cultures: A simulation study","display_name":"Modelling the effect of thickness on the electromechanical properties of in vitro cardiac cultures: A simulation study","publication_year":2015,"publication_date":"2015-08-01","ids":{"openalex":"https://openalex.org/W2224253494","doi":"https://doi.org/10.1109/embc.2015.7318293","mag":"2224253494","pmid":"https://pubmed.ncbi.nlm.nih.gov/26736193"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2015.7318293","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318293","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053408507","display_name":"Fabrizio Del Bianco","orcid":"https://orcid.org/0000-0002-6277-0145"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio Del Bianco","raw_affiliation_strings":["Department of Electrical, Computer and Biomedical Engineering, Centre for Tissue Engineering (C.LT.), Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical, Computer and Biomedical Engineering, Centre for Tissue Engineering (C.LT.), Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006394600","display_name":"Piero Colli Franzone","orcid":null},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Piero Colli Franzone","raw_affiliation_strings":["Department of Mathematics, University of Pavia, Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Pavia, Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028302493","display_name":"Simone Scacchi","orcid":"https://orcid.org/0000-0001-6011-784X"},"institutions":[{"id":"https://openalex.org/I189158943","display_name":"University of Milan","ror":"https://ror.org/00wjc7c48","country_code":"IT","type":"education","lineage":["https://openalex.org/I189158943"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simone Scacchi","raw_affiliation_strings":["Department of Mathematics, University of Milano, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Milano, Milano, Italy","institution_ids":["https://openalex.org/I189158943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074285976","display_name":"Lorenzo Fassina","orcid":"https://orcid.org/0000-0002-5587-4632"},"institutions":[{"id":"https://openalex.org/I25217355","display_name":"University of Pavia","ror":"https://ror.org/00s6t1f81","country_code":"IT","type":"education","lineage":["https://openalex.org/I25217355"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lorenzo Fassina","raw_affiliation_strings":["Department of Electrical, Computer and Biomedical Engineering, Centre for Tissue Engineering (C.I.T.), Pavia, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical, Computer and Biomedical Engineering, Centre for Tissue Engineering (C.I.T.), Pavia, Italy","institution_ids":["https://openalex.org/I25217355"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13759341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"29","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.6009581685066223},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5147247910499573},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.5030328631401062},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.48928138613700867},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.48793527483940125},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.4390491843223572},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.41078561544418335},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.39872652292251587},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3399887681007385},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.32723188400268555},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.24289143085479736},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.15379983186721802},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.15329253673553467},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1256268322467804}],"concepts":[{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6009581685066223},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5147247910499573},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5030328631401062},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.48928138613700867},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.48793527483940125},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4390491843223572},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.41078561544418335},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.39872652292251587},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3399887681007385},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.32723188400268555},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.24289143085479736},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.15379983186721802},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.15329253673553467},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1256268322467804},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016276","descriptor_name":"Ventricular Function","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2015.7318293","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2015.7318293","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:26736193","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26736193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W26072533","https://openalex.org/W1502527850","https://openalex.org/W1974388426","https://openalex.org/W1977539009","https://openalex.org/W1997971146","https://openalex.org/W2004174872","https://openalex.org/W2051493710","https://openalex.org/W2069058079","https://openalex.org/W2098457073","https://openalex.org/W2102339840","https://openalex.org/W2105695618","https://openalex.org/W2110256784","https://openalex.org/W2131308633","https://openalex.org/W2134053621","https://openalex.org/W2335088247","https://openalex.org/W2476441940","https://openalex.org/W2477424666","https://openalex.org/W2497351868","https://openalex.org/W4242465417","https://openalex.org/W6679490775"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W2056555318","https://openalex.org/W2333605542"],"abstract_inverted_index":{"Nowadays,":[0],"in":[1,30,54,65,80,122],"vitro":[2,55],"cardiac":[3,96],"cultures":[4],"offer":[5],"a":[6,38,77,95,109],"valid":[7],"tool":[8],"to":[9,42,70,93,117],"study":[10,43],"the":[11,15,18,47,82,85,118,121,131,141,144,148,155],"bioelectrical":[12,48],"activity":[13],"and":[14,49],"biomechanics":[16],"of":[17,52,58,84,120,133],"heart":[19,124],"tissue.":[20],"Modelling":[21],"their":[22],"properties":[23],"could":[24],"be":[25,76],"helpful":[26],"for":[27,99],"researchers":[28],"involved":[29],"this":[31,34,89,100],"field.":[32],"In":[33,61],"paper,":[35],"we":[36,68,102],"develop":[37],"three-dimensional":[39],"electromechanical":[40],"model":[41],"how":[44],"thickness":[45,73,146],"affects":[46],"biomechanical":[50],"performances":[51],"an":[53],"culture":[56,87],"made":[57],"ventricular":[59],"cells.":[60],"particular,":[62],"by":[63],"our":[64],"silico":[66],"simulations":[67],"want":[69],"verify":[71],"if":[72],"variations":[74],"can":[75],"key":[78],"factor":[79],"modifying":[81],"response":[83],"whole":[86],"when":[88],"one":[90,119],"is":[91,115,127],"grown":[92],"become":[94],"patch.":[97],"Therefore,":[98],"parameter":[101],"choose":[103],"three":[104],"increasing":[105],"values":[106],"while":[107],"keeping":[108],"fiber":[110],"architecture":[111],"among":[112],"layers":[113],"that":[114],"similar":[116],"vivo":[123],"but":[125,154],"it":[126],"randomly":[128],"stated":[129],"at":[130],"beginning":[132],"each":[134],"simulation.":[135],"We":[136],"prove":[137],"that,":[138],"independently":[139],"from":[140],"selected":[142],"architectures,":[143],"more":[145,149,156],"increases":[147],"mechanical":[150],"improvements":[151],"are":[152],"attained,":[153],"electrical":[157],"problems":[158],"may":[159],"arise":[160],"too.":[161]},"counts_by_year":[],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}