{"id":"https://openalex.org/W2330113144","doi":"https://doi.org/10.1109/embc.2014.6945162","title":"Tissue specific arterial spin labeling fMRI: A superior method for imaging cerebral blood flow in aging and disease","display_name":"Tissue specific arterial spin labeling fMRI: A superior method for imaging cerebral blood flow in aging and disease","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2330113144","doi":"https://doi.org/10.1109/embc.2014.6945162","mag":"2330113144","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571530"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6945162","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112544783","display_name":"Yujie Qiu","orcid":null},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yujie Qiu","raw_affiliation_strings":["Department of Biomedical Engineering, Rochester Institute of Technology, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Rochester Institute of Technology, NY, USA","institution_ids":["https://openalex.org/I155173764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070493288","display_name":"Ajna Borogovac","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ajna Borogovac","raw_affiliation_strings":["HAProxy Technologies Inc., USA"],"affiliations":[{"raw_affiliation_string":"HAProxy Technologies Inc., USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090489079","display_name":"Andrew F. Laine","orcid":"https://orcid.org/0000-0003-3797-0628"},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Laine","raw_affiliation_strings":["Department of Biomedical Engineering, Columbia University, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Columbia University, NY, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017094330","display_name":"Joy Hirsch","orcid":"https://orcid.org/0000-0002-1418-6489"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joy Hirsch","raw_affiliation_strings":["Department of Psychiatry and Neurobiology, Yale University, CT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Neurobiology, Yale University, CT, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033281860","display_name":"Iris Asllani","orcid":"https://orcid.org/0000-0001-5469-1597"},"institutions":[{"id":"https://openalex.org/I155173764","display_name":"Rochester Institute of Technology","ror":"https://ror.org/00v4yb702","country_code":"US","type":"education","lineage":["https://openalex.org/I155173764"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Iris Asllani","raw_affiliation_strings":["Department of Biomedical Engineering, Rochester Institute of Technology, NY, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Rochester Institute of Technology, NY, USA","institution_ids":["https://openalex.org/I155173764"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5112544783"],"corresponding_institution_ids":["https://openalex.org/I155173764"],"apc_list":null,"apc_paid":null,"fwci":0.7836,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.75466805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"11","issue":null,"first_page":"6687","last_page":"6690"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.8756531476974487},{"id":"https://openalex.org/keywords/arterial-spin-labeling","display_name":"Arterial spin labeling","score":0.584210216999054},{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.574627161026001},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4773198068141937},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.4686545431613922},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.423210084438324},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4193948209285736},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4026205539703369},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.38585004210472107},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.34912630915641785},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.2710574269294739},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26893842220306396},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18462347984313965},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.1727156937122345},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14677488803863525},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.12142106890678406}],"concepts":[{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.8756531476974487},{"id":"https://openalex.org/C3018723549","wikidata":"https://www.wikidata.org/wiki/Q56284158","display_name":"Arterial spin labeling","level":3,"score":0.584210216999054},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.574627161026001},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4773198068141937},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4686545431613922},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.423210084438324},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4193948209285736},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4026205539703369},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38585004210472107},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.34912630915641785},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2710574269294739},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26893842220306396},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18462347984313965},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1727156937122345},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14677488803863525},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.12142106890678406},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001927","descriptor_name":"Brain Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013113","descriptor_name":"Spin Labels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6945162","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6945162","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25571530","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571530","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6000000238418579,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1989854445","https://openalex.org/W2012955685","https://openalex.org/W2024824783","https://openalex.org/W2036725789","https://openalex.org/W2040622355","https://openalex.org/W2042765211","https://openalex.org/W2061704145","https://openalex.org/W2064818171","https://openalex.org/W2076212130","https://openalex.org/W2104289741","https://openalex.org/W2111464173","https://openalex.org/W2119848633","https://openalex.org/W2154535553","https://openalex.org/W2160056785","https://openalex.org/W4231536152","https://openalex.org/W6813156634"],"related_works":["https://openalex.org/W2070060620","https://openalex.org/W2691788872","https://openalex.org/W2040386745","https://openalex.org/W2077850022","https://openalex.org/W2593787220","https://openalex.org/W2114144996","https://openalex.org/W2557712647","https://openalex.org/W1939164019","https://openalex.org/W1985261403","https://openalex.org/W2355116690"],"abstract_inverted_index":{"Cerebral":[0],"blood":[1],"flow":[2],"(CBF)":[3],"is":[4,32,58],"a":[5,74,140],"physiological":[6],"correlate":[7],"of":[8,40,53,93,106,115,133,152,165,186,191,203,234,256,262],"brain":[9,107,180],"function":[10],"and":[11,13,23,43,65,91,99,109,121,205,220,228,232,258,270],"metabolism":[12],"as":[14],"such":[15],"an":[16,33],"essential":[17],"parameter":[18],"for":[19,87,139,193,217,250],"investigating":[20],"how":[21],"aging":[22,269],"disease":[24],"affect":[25],"the":[26,104,113,131,150,163,166,201,212,235,254],"brain.":[27],"Arterial":[28],"spin":[29],"labeling":[30],"(ASL)":[31],"fMRI":[34],"method":[35,77],"that":[36,79,244],"provides":[37,80],"absolute":[38],"measurement":[39],"CBF":[41,86,117,154,198,252],"non-invasively":[42],"with":[44,119,144,156,223,268],"higher":[45,161,209],"spatial":[46],"resolution":[47],"than":[48,162],"non-MRI":[49],"methods.":[50],"However,":[51],"application":[52],"ASL":[54,76],"in":[55,69,197,200,253],"older":[56],"populations":[57],"hampered":[59],"by":[60,84,179],"partial":[61],"volume":[62],"effects":[63,105],"(PVE)":[64],"tissue":[66,89,94],"dependent":[67],"changes":[68,196],"CBF.":[70],"We":[71],"have":[72],"developed":[73],"tissue-specific":[75],"(ts-ASL)":[78],"`flow":[81],"density'":[82],"measures":[83],"quantifying":[85],"each":[88],"separately":[90],"independently":[92],"content.":[95],"Using":[96],"simulated":[97],"functional":[98],"structural":[100],"images,":[101],"we":[102],"investigated":[103],"atrophy":[108,204,219,257],"random":[110,141,259],"noise":[111,129,143,206,222],"on":[112],"SNR":[114,132,151,164],"GM":[116,153],"measured":[118],"conventional":[120,167,173,213,227],"ts-ASL.":[122],"Results":[123],"showed":[124],"that:":[125],"(1)":[126],"For":[127,137],"all":[128],"levels,":[130],"ts-ASL":[134,157,182,192,229,245],"was":[135,158,176,183,207],"higher.":[136],"example,":[138],"Gaussian":[142,221],"standard":[145],"deviation":[146],"\u03c3":[147,224],"=":[148,225],"4,":[149,226],"obtained":[155],"~3":[159],"times":[160],"method.":[168,214],"(2)":[169],"In":[170,215],"contrast":[171],"to":[172,211,266],"ASL,":[174],"which":[175,263],"substantially":[177],"affected":[178],"atrophy,":[181],"virtually":[184],"independent":[185],"it.":[187],"(3)":[188],"The":[189],"sensitivity":[190],"detecting":[194],"focal":[195],"(\u0394CBF)":[199],"presence":[202,255],"also":[208],"compared":[210],"hippocampus,":[216],"15%":[218],"retrieved":[230],"73%":[231],"90%":[233],"modeled":[236],"\u0394CBF,":[237],"respectively.":[238],"Taken":[239],"together,":[240],"these":[241],"results":[242],"indicate":[243],"may":[246],"be":[247],"better":[248],"suited":[249],"measuring":[251],"noise,":[260],"both":[261],"are":[264],"expected":[265],"increase":[267],"disease.":[271]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}