{"id":"https://openalex.org/W2327590933","doi":"https://doi.org/10.1109/embc.2014.6944944","title":"A testbed to explore the optimal electrical stimulation parameters for suppressing inter-ictal spikes in human hippocampal slices","display_name":"A testbed to explore the optimal electrical stimulation parameters for suppressing inter-ictal spikes in human hippocampal slices","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2327590933","doi":"https://doi.org/10.1109/embc.2014.6944944","mag":"2327590933","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571312"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089991463","display_name":"Min-Chi Hsiao","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-Chi Hsiao","raw_affiliation_strings":["Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California (USC), Los Angeles, CA 90089 USA","The Department of Biomedical Engineering, University of Southern California (USC), Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California (USC), Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, University of Southern California (USC), Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027662718","display_name":"Pen-Ning Yu","orcid":"https://orcid.org/0000-0003-0542-7356"},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pen-Ning Yu","raw_affiliation_strings":["Department of Biomedical Engineering, Center for Neural Engineering, USC, CA 90089 USA","The Department of Biomedical Engineering, Center for Neural Engineering, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Center for Neural Engineering, USC, CA 90089 USA","institution_ids":["https://openalex.org/I4210157890"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, Center for Neural Engineering, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070732235","display_name":"Dong Song","orcid":"https://orcid.org/0000-0002-6179-1120"},"institutions":[{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Song","raw_affiliation_strings":["Department of Biomedical Engineering, Center for Neural Engineering, USC, CA 90089 USA","The Department of Biomedical Engineering, Center for Neural Engineering, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Center for Neural Engineering, USC, CA 90089 USA","institution_ids":["https://openalex.org/I4210157890"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, Center for Neural Engineering, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016156250","display_name":"Charles Y. Liu","orcid":"https://orcid.org/0000-0001-6423-8577"},"institutions":[{"id":"https://openalex.org/I2802549562","display_name":"Rancho Los Amigos National Rehabilitation Center","ror":"https://ror.org/03t3q6164","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I2802549562"]},{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Y. Liu","raw_affiliation_strings":["Department of Neurological Surgery and Neurology, USC Keck School of Medicine, USC Center for Neurorestoration, and Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242 USA","The Department of Neurological Surgery and Neurology, USC Center for Neurorestoration, and Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery and Neurology, USC Keck School of Medicine, USC Center for Neurorestoration, and Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242 USA","institution_ids":["https://openalex.org/I2802549562"]},{"raw_affiliation_string":"The Department of Neurological Surgery and Neurology, USC Center for Neurorestoration, and Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA","institution_ids":["https://openalex.org/I2802549562","https://openalex.org/I4210157890"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853584","display_name":"Christi Heck","orcid":null},"institutions":[{"id":"https://openalex.org/I4210143575","display_name":"Epilepsy Action","ror":"https://ror.org/04r5yj356","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210143575"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christi N. Heck","raw_affiliation_strings":["Department of Neurology, Adult Comprehensive Epilepsy Program, USC Keck School of Medicine, and USC Center for Neurorestoration","The Department of Neurology, USC Keck School of Medicine, and USC Center for Neurorestoration"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Adult Comprehensive Epilepsy Program, USC Keck School of Medicine, and USC Center for Neurorestoration","institution_ids":["https://openalex.org/I4210143575"]},{"raw_affiliation_string":"The Department of Neurology, USC Keck School of Medicine, and USC Center for Neurorestoration","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112386761","display_name":"David Millett","orcid":null},"institutions":[{"id":"https://openalex.org/I2802549562","display_name":"Rancho Los Amigos National Rehabilitation Center","ror":"https://ror.org/03t3q6164","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I2802549562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Millett","raw_affiliation_strings":["Department of Neurology, Keck Hospital of USC, and Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242. USA","The Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Keck Hospital of USC, and Rancho Los Amigos National Rehabilitation Center, Downey, CA 90242. USA","institution_ids":["https://openalex.org/I2802549562"]},{"raw_affiliation_string":"The Department of Neurology, Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA","institution_ids":["https://openalex.org/I2802549562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911478","display_name":"Theodore W. Berger","orcid":null},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore W. Berger","raw_affiliation_strings":["Department of Biomedical Engineering, Center for Neural Engineering, and the Program in Neuroscience, USC, Los Angeles, CA 90089 USA","The Department of Biomedical Engineering, Center for Neural Engineering, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Center for Neural Engineering, and the Program in Neuroscience, USC, Los Angeles, CA 90089 USA","institution_ids":["https://openalex.org/I1342924430"]},{"raw_affiliation_string":"The Department of Biomedical Engineering, Center for Neural Engineering, Los Angeles, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"2014","issue":null,"first_page":"5792","last_page":"5795"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurostimulation","display_name":"Neurostimulation","score":0.8063152432441711},{"id":"https://openalex.org/keywords/testbed","display_name":"Testbed","score":0.7690141201019287},{"id":"https://openalex.org/keywords/vagus-nerve-stimulation","display_name":"Vagus nerve stimulation","score":0.7501413226127625},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.7173649072647095},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6895685791969299},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.6651349067687988},{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.6470674276351929},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.6269963979721069},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5702822208404541},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"Neuromodulation","score":0.45306453108787537},{"id":"https://openalex.org/keywords/brain-stimulation","display_name":"Brain stimulation","score":0.42107006907463074},{"id":"https://openalex.org/keywords/neurophysiology","display_name":"Neurophysiology","score":0.4170127213001251},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.4102596640586853},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.327761173248291},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.306912362575531},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.26705485582351685},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"Vagus nerve","score":0.1607300341129303}],"concepts":[{"id":"https://openalex.org/C2776443511","wikidata":"https://www.wikidata.org/wiki/Q1724687","display_name":"Neurostimulation","level":3,"score":0.8063152432441711},{"id":"https://openalex.org/C31395832","wikidata":"https://www.wikidata.org/wiki/Q1318674","display_name":"Testbed","level":2,"score":0.7690141201019287},{"id":"https://openalex.org/C2780087125","wikidata":"https://www.wikidata.org/wiki/Q2062293","display_name":"Vagus nerve stimulation","level":4,"score":0.7501413226127625},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7173649072647095},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6895685791969299},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6651349067687988},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.6470674276351929},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6269963979721069},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5702822208404541},{"id":"https://openalex.org/C2780375056","wikidata":"https://www.wikidata.org/wiki/Q905905","display_name":"Neuromodulation","level":3,"score":0.45306453108787537},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.42107006907463074},{"id":"https://openalex.org/C152478114","wikidata":"https://www.wikidata.org/wiki/Q660910","display_name":"Neurophysiology","level":2,"score":0.4170127213001251},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.4102596640586853},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.327761173248291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.306912362575531},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.26705485582351685},{"id":"https://openalex.org/C2781404750","wikidata":"https://www.wikidata.org/wiki/Q190140","display_name":"Vagus nerve","level":3,"score":0.1607300341129303},{"id":"https://openalex.org/C31258907","wikidata":"https://www.wikidata.org/wiki/Q1301371","display_name":"Computer network","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004833","descriptor_name":"Epilepsy, Temporal Lobe","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6944944","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944944","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25571312","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1505432807","https://openalex.org/W1973046862","https://openalex.org/W1973929174","https://openalex.org/W1974992743","https://openalex.org/W2009253761","https://openalex.org/W2010954353","https://openalex.org/W2013337212","https://openalex.org/W2017549188","https://openalex.org/W2027129354","https://openalex.org/W2047743367","https://openalex.org/W2086752457","https://openalex.org/W2096688703","https://openalex.org/W2132239918","https://openalex.org/W2135210312","https://openalex.org/W2135629133","https://openalex.org/W2156969532","https://openalex.org/W6653137086"],"related_works":["https://openalex.org/W2306489308","https://openalex.org/W2098126715","https://openalex.org/W4387677702","https://openalex.org/W4301397033","https://openalex.org/W2086785494","https://openalex.org/W2139634852","https://openalex.org/W1483061794","https://openalex.org/W2198765973","https://openalex.org/W4200466513","https://openalex.org/W4392298994"],"abstract_inverted_index":{"New":[0],"interventions":[1],"using":[2,98],"neuromodulatory":[3,220],"devices":[4],"such":[5],"as":[6],"vagus":[7],"nerve":[8],"stimulation,":[9],"deep":[10],"brain":[11],"stimulation":[12,49,64,69,82,163,188],"and":[13,34,75,207],"responsive":[14],"neurostimulation":[15,143],"are":[16,39,168],"available":[17],"or":[18,44],"under":[19],"study":[20],"for":[21,139,184,201,219],"the":[22,28,32,37,47,141,154,157,166,186,199,203],"treatment":[23],"of":[24,31,36,62,80,190,215],"refractory":[25],"epilepsy.":[26,108],"Since":[27],"actual":[29],"mechanisms":[30],"onset":[33],"termination":[35],"seizure":[38,134,191],"still":[40],"unclear,":[41],"most":[42,204],"researchers":[43],"clinicians":[45],"determine":[46],"optimal":[48,81,187],"parameters":[50,65,164,189],"through":[51],"trial-and-error":[52],"procedures.":[53],"It":[54],"is":[55],"necessary":[56],"to":[57,84,136,145,152,159,165,212],"further":[58,129],"explore":[59],"what":[60],"types":[61],"electrical":[63,162],"(these":[66],"may":[67,208],"include":[68],"frequency,":[70],"amplitude,":[71],"duration,":[72],"interval":[73],"pattern,":[74],"location)":[76],"constitute":[77],"a":[78,88,110,137,182],"set":[79],"paradigms":[83,144,218],"suppress":[85],"seizures.":[86],"In":[87,124],"previous":[89],"study,":[90,126],"we":[91,127],"developed":[92],"an":[93],"in":[94,132,170],"vitro":[95,133],"epilepsy":[96],"model":[97,135],"hippocampal":[99,119],"slices":[100,120,167],"from":[101,104,117],"patients":[102],"suffering":[103],"mesial":[105],"temporal":[106],"lobe":[107],"Using":[109],"planar":[111],"multi-electrode":[112],"array":[113],"system,":[114],"inter-ictal":[115,147],"activity":[116],"human":[118],"was":[121],"consistently":[122],"recorded.":[123],"this":[125,131,171,177,195],"have":[128],"transferred":[130],"testbed":[138,179,196],"exploring":[140],"possible":[142],"inhibit":[146],"spikes.":[148],"The":[149,173],"methodology":[150],"used":[151,211],"collect":[153],"electrophysiological":[155],"data,":[156],"approach":[158],"apply":[160],"different":[161],"provided":[169],"paper.":[172],"results":[174],"show":[175],"that":[176],"experimental":[178],"will":[180,197],"provide":[181],"platform":[183],"testing":[185],"cessation.":[192],"We":[193],"expect":[194],"expedite":[198],"process":[200],"identifying":[202],"effective":[205],"parameters,":[206],"ultimately":[209],"be":[210],"guide":[213],"programming":[214],"new":[216],"stimulating":[217],"devices.":[221]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}