{"id":"https://openalex.org/W2063282898","doi":"https://doi.org/10.1109/embc.2014.6944896","title":"Support vector regression based multivariate lesion-symptom mapping","display_name":"Support vector regression based multivariate lesion-symptom mapping","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2063282898","doi":"https://doi.org/10.1109/embc.2014.6944896","mag":"2063282898","pmid":"https://pubmed.ncbi.nlm.nih.gov/25571264"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944896","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101451636","display_name":"Yongsheng Zhang","orcid":"https://orcid.org/0000-0002-6401-4685"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yongsheng Zhang","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA, USA","University of Pennsylvania Philadelphia, PA 19104 (USA)"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania Philadelphia, PA 19104 (USA)","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012820610","display_name":"Daniel Y. Kimberg","orcid":null},"institutions":[{"id":"https://openalex.org/I1291425158","display_name":"Google (United States)","ror":"https://ror.org/00njsd438","country_code":"US","type":"company","lineage":["https://openalex.org/I1291425158","https://openalex.org/I4210128969"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Y. Kimberg","raw_affiliation_strings":["Google (United States), Mountain View, United States"],"affiliations":[{"raw_affiliation_string":"Google (United States), Mountain View, United States","institution_ids":["https://openalex.org/I1291425158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049854864","display_name":"H. Branch Coslett","orcid":"https://orcid.org/0000-0001-5669-6236"},"institutions":[{"id":"https://openalex.org/I922845939","display_name":"Philadelphia University","ror":"https://ror.org/03zzmyz63","country_code":"US","type":"education","lineage":["https://openalex.org/I922845939"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Branch Coslett","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, United States"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, United States","institution_ids":["https://openalex.org/I922845939","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045338876","display_name":"Myrna F. Schwartz","orcid":null},"institutions":[{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myrna F. Schwartz","raw_affiliation_strings":["Yeshiva University, New York, United States"],"affiliations":[{"raw_affiliation_string":"Yeshiva University, New York, United States","institution_ids":["https://openalex.org/I19772626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028412545","display_name":"Ze Wang","orcid":"https://orcid.org/0000-0001-9700-7900"},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ze Wang","raw_affiliation_strings":["University of Pennsylvania, Philadelphia, PA, USA","University of Pennsylvania Philadelphia, PA 19104 (USA)"],"affiliations":[{"raw_affiliation_string":"University of Pennsylvania, Philadelphia, PA, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"University of Pennsylvania Philadelphia, PA 19104 (USA)","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101451636"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.1531,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.50996506,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2014","issue":null,"first_page":"5599","last_page":"5602"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.8674454092979431},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7294678092002869},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6406602263450623},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.623509407043457},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6029760837554932},{"id":"https://openalex.org/keywords/lesion","display_name":"Lesion","score":0.5933679342269897},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5505280494689941},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.5032610297203064},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.4591189920902252},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2757783830165863},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21913999319076538},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.21707630157470703},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17753595113754272},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.17253509163856506},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14498433470726013},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.10531982779502869}],"concepts":[{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.8674454092979431},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7294678092002869},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6406602263450623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.623509407043457},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6029760837554932},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5933679342269897},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5505280494689941},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.5032610297203064},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.4591189920902252},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2757783830165863},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21913999319076538},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.21707630157470703},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17753595113754272},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.17253509163856506},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14498433470726013},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10531982779502869}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6944896","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944896","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25571264","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25571264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1964357740","https://openalex.org/W1966576799","https://openalex.org/W1968114652","https://openalex.org/W1989371212","https://openalex.org/W1995244594","https://openalex.org/W2008225499","https://openalex.org/W2014076973","https://openalex.org/W2021209066","https://openalex.org/W2028602316","https://openalex.org/W2061035037","https://openalex.org/W2095609939","https://openalex.org/W2119821739","https://openalex.org/W2133967041","https://openalex.org/W2134765652","https://openalex.org/W2153635508","https://openalex.org/W2153857579","https://openalex.org/W2156909104","https://openalex.org/W2162854286","https://openalex.org/W4239510810"],"related_works":["https://openalex.org/W3027020613","https://openalex.org/W2016533837","https://openalex.org/W3167885074","https://openalex.org/W2892386716","https://openalex.org/W4306164210","https://openalex.org/W1998563493","https://openalex.org/W4313316311","https://openalex.org/W2327340211","https://openalex.org/W4362608745","https://openalex.org/W2383143032"],"abstract_inverted_index":{"A":[0],"novel":[1],"multivariate":[2,92],"lesion-symptom":[3,145],"mapping":[4,38,95],"(LSM)":[5],"methodology":[6],"was":[7,177],"developed":[8],"in":[9,97,137],"this":[10,98],"study.":[11],"Lesion":[12],"analysis":[13],"is":[14,59,123],"a":[15,64,75,126,138,158],"classic":[16],"model":[17],"for":[18,52,62,168,179],"studying":[19],"brain":[20],"functions.":[21],"Using":[22],"lesion":[23,36,93,116,180],"data,":[24],"focal":[25],"brain-behavior":[26,71,170],"associations":[27,72],"have":[28],"been":[29],"widely":[30],"assessed":[31],"using":[32,100,125,148],"the":[33,53,70,90,106,110,114,130,175],"massive":[34],"voxel-based":[35],"symptom":[37,94,111],"(VLSM)":[39],"method.":[40],"Assessing":[41],"each":[42,120],"voxel":[43,122],"independently,":[44],"VLSM":[45],"suffers":[46],"from":[47],"low":[48],"sensitivity":[49,165],"after":[50],"correcting":[51],"enormous":[54],"number":[55],"of":[56,77,164],"comparisons.":[57],"It":[58],"also":[60],"incapable":[61],"assessing":[63],"spatially":[65],"distributed":[66],"association":[67],"pattern":[68],"though":[69],"generally":[73],"involve":[74],"collection":[76],"functionally":[78],"related":[79],"voxels.":[80],"To":[81],"solve":[82],"these":[83],"two":[84],"outstanding":[85],"problems,":[86],"we":[87],"carried":[88],"out":[89],"first":[91],"(MLSM)":[96],"study":[99],"support":[101],"vector":[102],"regression":[103],"(SVR).":[104],"In":[105],"so":[107,129],"dubbed":[108],"SVR-LSM,":[109],"relation":[112],"to":[113,143,184],"entire":[115],"map":[117],"rather":[118],"than":[119,172],"isolated":[121],"modeled":[124],"non-linear":[127],"function,":[128],"inter-voxel":[131],"correlations":[132],"are":[133],"intrinsically":[134],"considered,":[135],"resulting":[136],"potentially":[139],"more":[140],"sensitive":[141],"way":[142],"examine":[144],"relationships.":[146],"Evaluations":[147],"synthetic":[149],"data":[150,153,186],"and":[151,166],"real":[152],"showed":[154],"that":[155],"SVR-LSM":[156],"gained":[157],"much":[159],"better":[160],"performance":[161],"(in":[162],"terms":[163],"specificity)":[167],"detecting":[169],"relations":[171],"VLSM.":[173],"While":[174],"method":[176],"designed":[178],"analysis,":[181],"extending":[182],"it":[183],"neuroimaging":[185],"will":[187],"be":[188],"straightforward.":[189]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}