{"id":"https://openalex.org/W2325776865","doi":"https://doi.org/10.1109/embc.2014.6944482","title":"A potential translational approach for bone tissue engineering through endochondral ossification","display_name":"A potential translational approach for bone tissue engineering through endochondral ossification","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2325776865","doi":"https://doi.org/10.1109/embc.2014.6944482","mag":"2325776865","pmid":"https://pubmed.ncbi.nlm.nih.gov/25570850"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944482","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944482","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050790167","display_name":"Paiyz E. Mikael","orcid":"https://orcid.org/0000-0003-4679-9770"},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paiyz E. Mikael","raw_affiliation_strings":["University of Connecticut, Storrs, CT, US"],"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, CT, US","institution_ids":["https://openalex.org/I140172145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052476841","display_name":"Xiaonan Xin","orcid":null},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaonan Xin","raw_affiliation_strings":["Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031803835","display_name":"Maria L. Urso","orcid":"https://orcid.org/0000-0001-8906-4673"},"institutions":[{"id":"https://openalex.org/I4210138222","display_name":"Isto Biologics (United States)","ror":"https://ror.org/043q2sq69","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138222"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Urso","raw_affiliation_strings":["Arteriocyte, Cellular Therapies Medical Systems, Hopkinton, MA, USA"],"affiliations":[{"raw_affiliation_string":"Arteriocyte, Cellular Therapies Medical Systems, Hopkinton, MA, USA","institution_ids":["https://openalex.org/I4210138222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101631387","display_name":"Xi Jiang","orcid":"https://orcid.org/0000-0001-9815-9885"},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xi Jiang","raw_affiliation_strings":["Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112315758","display_name":"Liping Wang","orcid":"https://orcid.org/0000-0002-9594-026X"},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liping Wang","raw_affiliation_strings":["Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110569541","display_name":"Brian R. Barnes","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138222","display_name":"Isto Biologics (United States)","ror":"https://ror.org/043q2sq69","country_code":"US","type":"company","lineage":["https://openalex.org/I4210138222"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Barnes","raw_affiliation_strings":["Arteriocyte, Cellular Therapies Medical Systems, Hopkinton, MA, USA"],"affiliations":[{"raw_affiliation_string":"Arteriocyte, Cellular Therapies Medical Systems, Hopkinton, MA, USA","institution_ids":["https://openalex.org/I4210138222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032733793","display_name":"Alexander C. Lichtler","orcid":"https://orcid.org/0000-0002-9243-0977"},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander C. Lichtler","raw_affiliation_strings":["UConn Health, Farmington, CT, US"],"affiliations":[{"raw_affiliation_string":"UConn Health, Farmington, CT, US","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067453135","display_name":"David W. Rowe","orcid":"https://orcid.org/0000-0001-7852-7775"},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Rowe","raw_affiliation_strings":["Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA"],"affiliations":[{"raw_affiliation_string":"Department of Reconstructive Sciences, University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036309473","display_name":"Syam P. Nukavarapu","orcid":"https://orcid.org/0000-0003-0852-9489"},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"funder","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Syam P. Nukavarapu","raw_affiliation_strings":["Institute for Regenerative Engineering, The University of Connecticut Health Center, Farmington, CT, USA"],"affiliations":[{"raw_affiliation_string":"Institute for Regenerative Engineering, The University of Connecticut Health Center, Farmington, CT, USA","institution_ids":["https://openalex.org/I75929689"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5050790167"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":null,"apc_paid":null,"fwci":0.9341,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76118322,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2014","issue":null,"first_page":"3925","last_page":"3928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"Endochondral ossification","score":0.9230682849884033},{"id":"https://openalex.org/keywords/intramembranous-ossification","display_name":"Intramembranous ossification","score":0.8249786496162415},{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.6999500393867493},{"id":"https://openalex.org/keywords/ossification","display_name":"Ossification","score":0.6088423132896423},{"id":"https://openalex.org/keywords/regeneration","display_name":"Regeneration (biology)","score":0.5626479983329773},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.5583660006523132},{"id":"https://openalex.org/keywords/chondrocyte","display_name":"Chondrocyte","score":0.5245975852012634},{"id":"https://openalex.org/keywords/bone-healing","display_name":"Bone healing","score":0.497936487197876},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.4791785478591919},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"Bone marrow","score":0.4719471335411072},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3931121826171875},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.26132524013519287},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.2528246343135834},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.22603914141654968},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1716616153717041}],"concepts":[{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.9230682849884033},{"id":"https://openalex.org/C188945261","wikidata":"https://www.wikidata.org/wiki/Q10746904","display_name":"Intramembranous ossification","level":2,"score":0.8249786496162415},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6999500393867493},{"id":"https://openalex.org/C2778842504","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Ossification","level":2,"score":0.6088423132896423},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5626479983329773},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5583660006523132},{"id":"https://openalex.org/C2781403057","wikidata":"https://www.wikidata.org/wiki/Q775480","display_name":"Chondrocyte","level":3,"score":0.5245975852012634},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.497936487197876},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4791785478591919},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4719471335411072},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3931121826171875},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26132524013519287},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2528246343135834},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22603914141654968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1716616153717041}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014945","descriptor_name":"Wound Healing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045164","descriptor_name":"Mesenchymal Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6944482","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944482","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25570850","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25570850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320318579","display_name":"China Building Materials Academy","ror":"https://ror.org/020q9r015"},{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1586291598","https://openalex.org/W1979320290","https://openalex.org/W1986335724","https://openalex.org/W1988592246","https://openalex.org/W1996626693","https://openalex.org/W2007310752","https://openalex.org/W2015639342","https://openalex.org/W2019592328","https://openalex.org/W2020700245","https://openalex.org/W2030922043","https://openalex.org/W2052035616","https://openalex.org/W2070304635","https://openalex.org/W2070454881","https://openalex.org/W2073346348","https://openalex.org/W2085895218","https://openalex.org/W2096467350","https://openalex.org/W2110401859","https://openalex.org/W2116581287","https://openalex.org/W2287893879","https://openalex.org/W2290315896","https://openalex.org/W6635261261"],"related_works":["https://openalex.org/W18760785","https://openalex.org/W1774377056","https://openalex.org/W2965890438","https://openalex.org/W2010247342","https://openalex.org/W2106253741","https://openalex.org/W2036557984","https://openalex.org/W1979379348","https://openalex.org/W2041636168","https://openalex.org/W2218923589","https://openalex.org/W2043675188"],"abstract_inverted_index":{"Bone":[0],"defect":[1],"repair":[2,95],"is":[3,62,75],"a":[4,52,105,130,157],"significant":[5],"clinical":[6,123],"challenge":[7],"in":[8,34,47,172,180],"orthopedic":[9],"surgery.":[10],"Despite":[11],"tremendous":[12],"efforts,":[13],"the":[14,17,90,94,134,163],"majority":[15],"of":[16,79,98,107,165],"current":[18],"bone":[19,25,39,49,102,112,153,167,178],"tissue":[20],"engineering":[21],"strategies":[22],"depend":[23],"on":[24],"formation":[26,113,176],"via":[27,156],"intramembranous":[28],"ossification":[29,58],"(IO),":[30],"which":[31],"often":[32],"results":[33],"poor":[35],"vascularization":[36,74],"and":[37,72,96,100,137,161,177],"limited-area":[38],"regeneration.":[40],"Recently,":[41],"there":[42,116],"has":[43],"been":[44],"increasing":[45],"interest":[46],"exploring":[48],"regeneration":[50,97,179],"through":[51,70,114],"cartilage-mediated":[53],"process":[54,160],"similar":[55],"to":[56,87],"endochondral":[57],"(EO).":[59],"This":[60],"method":[61,92],"advantageous":[63],"because":[64],"long":[65],"bones":[66],"are":[67,117],"originally":[68],"developed":[69],"EO":[71,91],"moreover,":[73],"an":[76],"inherent":[77],"step":[78],"this":[80,126],"process.":[81],"Therefore,":[82],"it":[83],"may":[84],"be":[85],"possible":[86],"effectively":[88],"employ":[89],"for":[93,121,171],"large":[99],"segmental":[101],"defects.":[103],"Although":[104],"number":[106],"studies":[108],"have":[109],"demonstrated":[110,162],"engineered":[111],"EO,":[115],"no":[118],"approaches":[119],"aiming":[120],"their":[122],"translation.":[124],"In":[125,147],"study,":[127],"we":[128,150],"propose":[129],"strategy":[131],"modeled":[132],"after":[133],"U.S.":[135],"Food":[136],"Drug":[138],"Administration":[139],"(FDA)":[140],"approved":[141],"autologus":[142],"chondrocyte":[143],"implantation":[144],"(ACI)":[145],"procedure.":[146],"its":[148],"implementation,":[149],"concentrated":[151],"human":[152,166],"marrow":[154,168],"aspirate":[155],"minimally":[158],"manipulated":[159],"potential":[164],"derived":[169],"cells":[170],"vitro":[173],"pre-cartilage":[174],"template":[175],"vivo.":[181]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
