{"id":"https://openalex.org/W2059349788","doi":"https://doi.org/10.1109/embc.2014.6944479","title":"Reduction of water diffusion coefficient with increased engineered cartilage matrix growth observed using MRI","display_name":"Reduction of water diffusion coefficient with increased engineered cartilage matrix growth observed using MRI","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2059349788","doi":"https://doi.org/10.1109/embc.2014.6944479","mag":"2059349788","pmid":"https://pubmed.ncbi.nlm.nih.gov/25570847"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944479","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080753695","display_name":"Mrignayani Kotecha","orcid":"https://orcid.org/0000-0003-2264-0247"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210145583","display_name":"Bioengineering Center","ror":"https://ror.org/04f0ydx59","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210145583"]}],"countries":["RU","US"],"is_corresponding":true,"raw_author_name":"Mrignayani Kotecha","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA","Bioengineering"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Bioengineering","institution_ids":["https://openalex.org/I4210145583"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062104616","display_name":"Thomas Schmid","orcid":"https://orcid.org/0000-0003-2745-7273"},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]},{"id":"https://openalex.org/I49886154","display_name":"Rush University","ror":"https://ror.org/01k9xac83","country_code":"US","type":"education","lineage":["https://openalex.org/I49886154"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas M. Schmid","raw_affiliation_strings":["Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA","Rush University"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Rush University Medical Center, Chicago, IL, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush University","institution_ids":["https://openalex.org/I49886154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006340080","display_name":"B. M. Odintsov","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Odintsov","raw_affiliation_strings":["Bachman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA","University of Illinois at Urbana Champaign"],"affiliations":[{"raw_affiliation_string":"Bachman Institute, University of Illinois at Urbana-Champaign, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"University of Illinois at Urbana Champaign","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006675553","display_name":"Richard L. Magin","orcid":"https://orcid.org/0000-0002-5103-1611"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard L. Magin","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA","[Department of Bioengineering, University of Illinois at Chicago]"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"[Department of Bioengineering, University of Illinois at Chicago]","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080753695"],"corresponding_institution_ids":["https://openalex.org/I39422238","https://openalex.org/I4210145583"],"apc_list":null,"apc_paid":null,"fwci":2.2475,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.87096881,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"47","issue":null,"first_page":"3913","last_page":"3916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11018","display_name":"Lower Extremity Biomechanics and Pathologies","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9271000027656555,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ascorbic-acid","display_name":"Ascorbic acid","score":0.7869960069656372},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"Extracellular matrix","score":0.7123633027076721},{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.7109127640724182},{"id":"https://openalex.org/keywords/matrix","display_name":"Matrix (chemical analysis)","score":0.5542560815811157},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"Tissue engineering","score":0.5325061082839966},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5273241400718689},{"id":"https://openalex.org/keywords/effective-diffusion-coefficient","display_name":"Effective diffusion coefficient","score":0.5163456201553345},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.48790451884269714},{"id":"https://openalex.org/keywords/vitamin","display_name":"Vitamin","score":0.4437357783317566},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3253107964992523},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.20521700382232666},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.19515764713287354},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.14830830693244934},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12931224703788757},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.062438517808914185}],"concepts":[{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.7869960069656372},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7123633027076721},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7109127640724182},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5542560815811157},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5325061082839966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5273241400718689},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.5163456201553345},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.48790451884269714},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4437357783317566},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3253107964992523},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.20521700382232666},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.19515764713287354},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.14830830693244934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12931224703788757},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.062438517808914185},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000464","descriptor_name":"Alginates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006603","descriptor_name":"Hexuronic Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020723","descriptor_name":"Glucuronic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6944479","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944479","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25570847","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25570847","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.8600000143051147}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W20480435","https://openalex.org/W179053432","https://openalex.org/W1975471671","https://openalex.org/W1979032537","https://openalex.org/W1980236137","https://openalex.org/W1991635667","https://openalex.org/W2050682586","https://openalex.org/W2057324851","https://openalex.org/W2060416311","https://openalex.org/W2061861207","https://openalex.org/W2070565156","https://openalex.org/W2079191512","https://openalex.org/W2106782312","https://openalex.org/W2112373627","https://openalex.org/W2117733036","https://openalex.org/W2124377144","https://openalex.org/W2184888822","https://openalex.org/W2187684329","https://openalex.org/W2330092035","https://openalex.org/W2993782230","https://openalex.org/W4285719527","https://openalex.org/W6607293756","https://openalex.org/W6686072613","https://openalex.org/W6771237908"],"related_works":["https://openalex.org/W2085044184","https://openalex.org/W4290258708","https://openalex.org/W2239919633","https://openalex.org/W2410155092","https://openalex.org/W1491785374","https://openalex.org/W1992943367","https://openalex.org/W2385551767","https://openalex.org/W2130767824","https://openalex.org/W2394979372","https://openalex.org/W3212964038"],"abstract_inverted_index":{"Non-destructive":[0],"monitoring":[1],"of":[2,16,35,91,148,157],"tissue-engineered":[3,163],"cartilage":[4,178],"growth":[5,10],"is":[6,42,171],"needed":[7],"to":[8,29,107,120,130,139],"optimize":[9],"conditions,":[11],"but":[12],"extracting":[13],"quantitative":[14],"biomarkers":[15],"extracellular":[17,159],"matrix":[18,160],"development":[19,156],"remains":[20],"a":[21,26,31,85,104,172],"technical":[22],"challenge.":[23],"MRI":[24,80],"provides":[25],"non-invasive":[27],"way":[28],"obtain":[30],"three":[32],"dimensional":[33],"map":[34],"growing":[36],"tissue":[37,45,179],"where":[38],"the":[39,50,73,121,126,146,154,158,162,168],"image":[40],"contrast":[41],"based":[43],"on":[44],"water":[46],"relaxation":[47],"times":[48],"and":[49,68,72,111,144],"apparent":[51],"diffusion":[52],"coefficient":[53],"(ADC).":[54],"In":[55],"this":[56],"study,":[57],"bovine":[58],"chondrocytes":[59],"were":[60,94],"seeded":[61],"in":[62,161],"alginate":[63],"beads":[64,123],"(0,":[65],"1,":[66],"2,":[67],"4":[69,142],"million":[70],"cells/ml)":[71],"ADC":[74,127,170],"was":[75,128],"measured":[76],"weekly":[77],"using":[78],"diffusion-weighted":[79],"at":[81,141],"14.1":[82],"T":[83],"over":[84],"one-month":[86],"incubation":[87,134],"period.":[88],"Two":[89],"groups":[90],"tissue-engineering":[92],"constructs":[93],"created:":[95],"one":[96],"with":[97,113,133,145],"ascorbic":[98,116],"acid":[99],"(vitamin":[100],"C)":[101],"added":[102,115],"as":[103],"vitamin":[105,149],"cofactor":[106],"increase":[108],"collagen":[109],"synthesis,":[110],"another":[112],"no":[114],"acid.":[117],"When":[118],"normalized":[119,169],"control":[122],"without":[124],"chondrocytes,":[125],"found":[129],"monotonically":[131],"fall":[132],"time":[135],"(decreasing":[136],"by":[137],"up":[138],"40%":[140],"weeks),":[143],"administration":[147],"C.":[150],"These":[151],"results":[152],"reflect":[153],"expected":[155],"constructs.":[164],"We":[165],"conclude":[166],"that":[167],"potential":[173],"biomarker":[174],"for":[175],"characterizing":[176],"engineered":[177],"growth.":[180]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
