{"id":"https://openalex.org/W2325561177","doi":"https://doi.org/10.1109/embc.2014.6944185","title":"A temporal interestingness measure for drug interaction signal detection in post-marketing surveillance","display_name":"A temporal interestingness measure for drug interaction signal detection in post-marketing surveillance","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2325561177","doi":"https://doi.org/10.1109/embc.2014.6944185","mag":"2325561177","pmid":"https://pubmed.ncbi.nlm.nih.gov/25570553"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944185","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944185","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102157880","display_name":"Yanqing Ji","orcid":null},"institutions":[{"id":"https://openalex.org/I119888943","display_name":"Gonzaga University","ror":"https://ror.org/03ze70h02","country_code":"US","type":"education","lineage":["https://openalex.org/I119888943"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanqing Ji","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Gonzaga University, Spokane, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Gonzaga University, Spokane, WA, USA","institution_ids":["https://openalex.org/I119888943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082640513","display_name":"Hao Ying","orcid":"https://orcid.org/0000-0002-4891-6785"},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Ying","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Wayne State University, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Wayne State University, MI, USA","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088006001","display_name":"John C. Tran","orcid":"https://orcid.org/0000-0003-1697-9404"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Tran","raw_affiliation_strings":["Frontier Behavioral Health, Spokane, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Frontier Behavioral Health, Spokane, WA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014004794","display_name":"Peter Dews","orcid":null},"institutions":[{"id":"https://openalex.org/I1304269903","display_name":"Trinity Health","ror":"https://ror.org/006z80t96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I1339176976","display_name":"Mercy Medical Center","ror":"https://ror.org/009raxq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339176976"]},{"id":"https://openalex.org/I4210115245","display_name":"St. Mary Mercy Livonia","ror":"https://ror.org/020whm440","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210115245"]},{"id":"https://openalex.org/I4210142528","display_name":"CHI Health Mercy Council Bluffs","ror":"https://ror.org/03w45gf56","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802665030","https://openalex.org/I2802797007","https://openalex.org/I4210142528"]},{"id":"https://openalex.org/I4210166159","display_name":"Mercy Hospital","ror":"https://ror.org/05rsdqb94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801024494","https://openalex.org/I4210166159"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Dews","raw_affiliation_strings":["Department of Medicine, St. Mary Mercy Hospital (Trinity Health), Livonia, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, St. Mary Mercy Hospital (Trinity Health), Livonia, MI, USA","institution_ids":["https://openalex.org/I4210115245","https://openalex.org/I4210166159","https://openalex.org/I1339176976","https://openalex.org/I4210142528","https://openalex.org/I1304269903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070815285","display_name":"Ayman Mansour","orcid":"https://orcid.org/0000-0001-7086-1613"},"institutions":[{"id":"https://openalex.org/I114432678","display_name":"Tafila Technical University","ror":"https://ror.org/04jzmk773","country_code":"JO","type":"education","lineage":["https://openalex.org/I114432678"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Ayman Mansour","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Tafila Technical University, Tafila, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Tafila Technical University, Tafila, Jordan","institution_ids":["https://openalex.org/I114432678"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008013450","display_name":"R. Michael Massanari","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Michael Massanari","raw_affiliation_strings":["Research for the Critical Junctures Institute, Bellingham, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research for the Critical Junctures Institute, Bellingham, WA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.16206441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"20","issue":null,"first_page":"2722","last_page":"2725"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9718000292778015,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measure","display_name":"Measure (data warehouse)","score":0.6555221080780029},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5798114538192749},{"id":"https://openalex.org/keywords/food-and-drug-administration","display_name":"Food and drug administration","score":0.5485759377479553},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4824293553829193},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.4207048714160919},{"id":"https://openalex.org/keywords/risk-analysis","display_name":"Risk analysis (engineering)","score":0.3605024814605713},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.33776265382766724},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22638288140296936},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.11478433012962341}],"concepts":[{"id":"https://openalex.org/C2780009758","wikidata":"https://www.wikidata.org/wiki/Q6804172","display_name":"Measure (data warehouse)","level":2,"score":0.6555221080780029},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5798114538192749},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.5485759377479553},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4824293553829193},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.4207048714160919},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.3605024814605713},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.33776265382766724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22638288140296936},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.11478433012962341},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008824","descriptor_name":"Michigan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008824","descriptor_name":"Michigan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008824","descriptor_name":"Michigan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011358","descriptor_name":"Product Surveillance, Postmarketing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057225","descriptor_name":"Data Mining","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6944185","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944185","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25570553","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25570553","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1981852586","https://openalex.org/W1988050416","https://openalex.org/W1992746042","https://openalex.org/W2009890917","https://openalex.org/W2035410307","https://openalex.org/W2037461646","https://openalex.org/W2098730643","https://openalex.org/W2103776471","https://openalex.org/W2117397379","https://openalex.org/W2119830391","https://openalex.org/W2149558152"],"related_works":["https://openalex.org/W4255837520","https://openalex.org/W2387011115","https://openalex.org/W2026337388","https://openalex.org/W1591825783","https://openalex.org/W4234808182","https://openalex.org/W4255628145","https://openalex.org/W2382043075","https://openalex.org/W2352440174","https://openalex.org/W2809151339","https://openalex.org/W2216913934"],"abstract_inverted_index":{"Drug-drug":[0],"interactions":[1],"(DDIs)":[2],"can":[3],"result":[4],"in":[5,16,147,159],"serious":[6],"consequences,":[7],"including":[8],"death.":[9],"Existing":[10],"methods":[11],"for":[12,48,163],"identifying":[13],"potential":[14,59,72,133,161],"DDIs":[15,60,73,134,162],"post-marketing":[17],"surveillance":[18],"primarily":[19],"rely":[20],"on":[21,69],"the":[22,76,80,89,114,142,154],"FDA's":[23],"(Food":[24],"and":[25,88,124,169],"Drug":[26],"Administration)":[27],"spontaneous":[28],"reporting":[29],"system.":[30],"However,":[31],"this":[32,52],"system":[33],"suffers":[34],"from":[35,135,141],"severe":[36],"underreporting,":[37],"which":[38],"makes":[39],"it":[40],"difficult":[41],"to":[42,57,112,131],"timely":[43],"collect":[44],"enough":[45],"valid":[46],"cases":[47,139],"statistical":[49],"analysis.":[50],"In":[51],"paper,":[53],"we":[54,67,100],"study":[55],"how":[56],"signal":[58],"using":[61,94],"patient":[62,138],"electronic":[63,137],"health":[64],"data.":[65],"Specifically,":[66],"focus":[68],"discovery":[70],"of":[71,83,86,91,116,122,156],"by":[74,174],"analyzing":[75],"temporal":[77,96,108,117],"relationships":[78],"between":[79,119],"concurrent":[81],"use":[82],"two":[84,120],"drugs":[85,121],"interest":[87,109,123],"occurrences":[90],"various":[92],"symptoms":[93],"novel":[95],"association":[97,118],"mining":[98],"techniques":[99],"developed.":[101],"A":[102],"new":[103],"interestingness":[104],"measure":[105,128],"called":[106],"functional":[107],"was":[110,129],"proposed":[111],"assess":[113],"degrees":[115],"each":[125],"symptom.":[126],"The":[127,150],"employed":[130],"screen":[132],"21,405":[136],"retrieved":[140],"Veterans":[143],"Affairs":[144],"Medical":[145],"Center":[146],"Detroit,":[148],"Michigan.":[149],"preliminary":[151],"results":[152],"indicate":[153],"usefulness":[155],"our":[157],"method":[158],"finding":[160],"further":[164],"analysis":[165],"(e.g.,":[166,171],"epidemiology":[167],"study)":[168],"investigation":[170],"case":[172],"review)":[173],"drug":[175],"safety":[176],"professionals.":[177]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
