{"id":"https://openalex.org/W2328043724","doi":"https://doi.org/10.1109/embc.2014.6944024","title":"Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor","display_name":"Detection of protein-small molecule binding using a self-referencing external cavity laser biosensor","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2328043724","doi":"https://doi.org/10.1109/embc.2014.6944024","mag":"2328043724","pmid":"https://pubmed.ncbi.nlm.nih.gov/25570392"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6944024","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://figshare.com/articles/journal_contribution/Detection_of_Protein_Small_Molecule_Binding_Using_a_Self_Referencing_External_Cavity_Laser_Biosensor/2032161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100671192","display_name":"Meng Zhang","orcid":"https://orcid.org/0000-0002-8217-042X"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Meng Zhang","raw_affiliation_strings":["Department of Physics, University of Illinois, Urbana, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Illinois, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038891328","display_name":"Jessie Peh","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessie Peh","raw_affiliation_strings":["Department of Chemistry, University of Illinois, Urbana, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027996458","display_name":"Paul J. Hergenrother","orcid":"https://orcid.org/0000-0001-9018-3581"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Hergenrother","raw_affiliation_strings":["Department of Chemistry, University of Illinois, Urbana, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075829379","display_name":"Brian T. Cunningham","orcid":"https://orcid.org/0000-0002-9681-2104"},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian T. Cunningham","raw_affiliation_strings":["Department of Bioengineering and Department of Electrical and Computer Engineering, University of Illinois, Urbana, IL, USA"],"affiliations":[{"raw_affiliation_string":"Department of Bioengineering and Department of Electrical and Computer Engineering, University of Illinois, Urbana, IL, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100671192"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":0.18498087,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.63501726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2014","issue":null,"first_page":"2073","last_page":"2076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10299","display_name":"Photonic and Optical Devices","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10299","display_name":"Photonic and Optical Devices","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.8579990863800049},{"id":"https://openalex.org/keywords/molecular-biophysics","display_name":"Molecular biophysics","score":0.537161111831665},{"id":"https://openalex.org/keywords/laser","display_name":"Laser","score":0.47163912653923035},{"id":"https://openalex.org/keywords/small-molecule","display_name":"Small molecule","score":0.4703614413738251},{"id":"https://openalex.org/keywords/molecule","display_name":"Molecule","score":0.41990557312965393},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.3884793817996979},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.37484410405158997},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.337188184261322},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33377885818481445},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.2577481269836426},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22214412689208984},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11474928259849548},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0875125527381897}],"concepts":[{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.8579990863800049},{"id":"https://openalex.org/C70636015","wikidata":"https://www.wikidata.org/wiki/Q4300350","display_name":"Molecular biophysics","level":2,"score":0.537161111831665},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.47163912653923035},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4703614413738251},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41990557312965393},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3884793817996979},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.37484410405158997},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.337188184261322},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33377885818481445},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2577481269836426},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22214412689208984},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11474928259849548},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0875125527381897},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004800","descriptor_name":"Enzymes, Immobilized","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007834","descriptor_name":"Lasers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013876","descriptor_name":"Thiophenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015374","descriptor_name":"Biosensing Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024402","descriptor_name":"Carbonic Anhydrase II","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2014.6944024","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6944024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25570392","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25570392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:figshare.com:article/2032161","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Detection_of_Protein_Small_Molecule_Binding_Using_a_Self_Referencing_External_Cavity_Laser_Biosensor/2032161","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:figshare.com:article/2032161","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Detection_of_Protein_Small_Molecule_Binding_Using_a_Self_Referencing_External_Cavity_Laser_Biosensor/2032161","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1593388227","https://openalex.org/W1991001144","https://openalex.org/W2000565132","https://openalex.org/W2023057253","https://openalex.org/W2035196020","https://openalex.org/W2040686536","https://openalex.org/W2058327406","https://openalex.org/W2080047316","https://openalex.org/W2080207536","https://openalex.org/W2087878478","https://openalex.org/W2090438628","https://openalex.org/W2098584554","https://openalex.org/W2107716719","https://openalex.org/W2128900650","https://openalex.org/W2129824355","https://openalex.org/W2338091342","https://openalex.org/W4240886723"],"related_works":["https://openalex.org/W2046430340","https://openalex.org/W2383021773","https://openalex.org/W2322026400","https://openalex.org/W4206515393","https://openalex.org/W1990396141","https://openalex.org/W2053796608","https://openalex.org/W4378648174","https://openalex.org/W2328840566","https://openalex.org/W2138021289","https://openalex.org/W4321079940"],"abstract_inverted_index":{"High":[0],"throughput":[1,105],"screening":[2],"of":[3,61,69,95,106],"protein-small":[4],"molecule":[5],"binding":[6,62,74],"interactions":[7],"using":[8],"label-free":[9],"optical":[10],"biosensors":[11],"is":[12],"challenging,":[13],"as":[14],"the":[15,54,80,93,100,104,107],"detected":[16],"signals":[17],"are":[18,131],"often":[19],"similar":[20],"in":[21,79,92,127],"magnitude":[22],"to":[23,82,89],"experimental":[24],"noise.":[25],"Here,":[26],"we":[27,58,113],"describe":[28],"a":[29,67,115,138],"novel":[30],"self-referencing":[31,55],"external":[32],"cavity":[33],"laser":[34],"(ECL)":[35],"biosensor":[36],"approach":[37],"that":[38],"achieves":[39],"high":[40,43],"resolution":[41],"and":[42,66],"sensitivity,":[44],"while":[45],"eliminating":[46],"thermal":[47],"noise":[48],"with":[49,73],"sub-picometer":[50],"wavelength":[51],"accuracy.":[52],"Using":[53],"ECL":[56],"biosensor,":[57],"demonstrate":[59],"detection":[60,91],"between":[63],"small":[64],"molecules":[65,136],"variety":[68],"immobilized":[70],"protein":[71],"targets":[72],"affinities":[75],"or":[76],"inhibition":[77],"constants":[78],"sub-nanomolar":[81],"low":[83],"micromolar":[84],"range.":[85],"The":[86],"demonstrated":[87],"ability":[88],"perform":[90],"presence":[94],"several":[96],"interfering":[97],"compounds":[98],"opens":[99],"potential":[101],"for":[102,118],"increasing":[103],"approach.":[108],"As":[109],"an":[110],"example":[111],"application,":[112],"performed":[114],"\"needle-in-the-haystack\"":[116],"screen":[117],"inhibitors":[119,130],"against":[120],"carbonic":[121],"anhydrase":[122],"isozyme":[123],"II":[124],"(CA":[125],"II),":[126],"which":[128],"known":[129],"clearly":[132],"differentiated":[133],"from":[134],"inactive":[135],"within":[137],"compound":[139],"library.":[140]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-02-12T00:53:03.260389","created_date":"2025-10-10T00:00:00"}
