{"id":"https://openalex.org/W2054320734","doi":"https://doi.org/10.1109/embc.2014.6943800","title":"A comparison between direct and indirect measurements of neurotransmitter vesicle release dynamics: A computational study","display_name":"A comparison between direct and indirect measurements of neurotransmitter vesicle release dynamics: A computational study","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2054320734","doi":"https://doi.org/10.1109/embc.2014.6943800","mag":"2054320734","pmid":"https://pubmed.ncbi.nlm.nih.gov/25570168"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6943800","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485406","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075309711","display_name":"Eric Y. Hu","orcid":"https://orcid.org/0000-0002-1150-4576"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric Y. Hu","raw_affiliation_strings":["department of Biomedical Engineering, University of Southern California, Los Angeles, USA","Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA"],"affiliations":[{"raw_affiliation_string":"department of Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047655773","display_name":"Jean\u2010Marie C. Bouteiller","orcid":"https://orcid.org/0000-0003-3069-0826"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Marie C. Bouteiller","raw_affiliation_strings":["department of Biomedical Engineering, University of Southern California, Los Angeles, USA","Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA"],"affiliations":[{"raw_affiliation_string":"department of Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012709333","display_name":"Mike Huang","orcid":"https://orcid.org/0000-0002-7724-0315"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mike Huang","raw_affiliation_strings":["department of Biomedical Engineering, University of Southern California, Los Angeles, USA","Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA"],"affiliations":[{"raw_affiliation_string":"department of Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070732235","display_name":"Dong Song","orcid":"https://orcid.org/0000-0002-6179-1120"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Song","raw_affiliation_strings":["department of Biomedical Engineering, University of Southern California, Los Angeles, USA","Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA"],"affiliations":[{"raw_affiliation_string":"department of Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911478","display_name":"Theodore W. Berger","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theodore Berger","raw_affiliation_strings":["department of Biomedical Engineering, University of Southern California, Los Angeles, USA","Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA"],"affiliations":[{"raw_affiliation_string":"department of Biomedical Engineering, University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Univ. of Southern California,Los Angeles,USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5075309711"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.09132762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2014","issue":null,"first_page":"1155","last_page":"1158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.7724076509475708},{"id":"https://openalex.org/keywords/neurotransmitter","display_name":"Neurotransmitter","score":0.5338916182518005},{"id":"https://openalex.org/keywords/neurotransmitter-receptor","display_name":"Neurotransmitter receptor","score":0.5225919485092163},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5190604329109192},{"id":"https://openalex.org/keywords/vesicle","display_name":"Vesicle","score":0.4740407466888428},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.4523344039916992},{"id":"https://openalex.org/keywords/synaptic-vesicle","display_name":"Synaptic vesicle","score":0.4338385760784149},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4335378408432007},{"id":"https://openalex.org/keywords/active-zone","display_name":"Active zone","score":0.42112237215042114},{"id":"https://openalex.org/keywords/neurotransmission","display_name":"Neurotransmission","score":0.41246822476387024},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39950069785118103},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3155878782272339},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3047611713409424},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.08014935255050659},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.06683593988418579}],"concepts":[{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.7724076509475708},{"id":"https://openalex.org/C2776219046","wikidata":"https://www.wikidata.org/wiki/Q162657","display_name":"Neurotransmitter","level":3,"score":0.5338916182518005},{"id":"https://openalex.org/C156927020","wikidata":"https://www.wikidata.org/wiki/Q1187783","display_name":"Neurotransmitter receptor","level":3,"score":0.5225919485092163},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5190604329109192},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4740407466888428},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.4523344039916992},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.4338385760784149},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4335378408432007},{"id":"https://openalex.org/C187102610","wikidata":"https://www.wikidata.org/wiki/Q4677599","display_name":"Active zone","level":5,"score":0.42112237215042114},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.41246822476387024},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39950069785118103},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3155878782272339},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3047611713409424},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08014935255050659},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06683593988418579},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009482","descriptor_name":"Neurophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009482","descriptor_name":"Neurophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009482","descriptor_name":"Neurophysiology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018377","descriptor_name":"Neurotransmitter Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2014.6943800","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943800","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25570168","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25570168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4485406","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4485406","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4485406","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Conf Proc IEEE Eng Med Biol Soc","raw_type":"Text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2039534934","https://openalex.org/W2054625340","https://openalex.org/W2062619493","https://openalex.org/W2095873412","https://openalex.org/W2096701787","https://openalex.org/W2096916130","https://openalex.org/W2106125417","https://openalex.org/W2116573581","https://openalex.org/W2117120818","https://openalex.org/W2118064450","https://openalex.org/W2135163309","https://openalex.org/W2159133961","https://openalex.org/W2169875888","https://openalex.org/W6660533174","https://openalex.org/W6677387105"],"related_works":["https://openalex.org/W2022792040","https://openalex.org/W1558357192","https://openalex.org/W1964189494","https://openalex.org/W4243486868","https://openalex.org/W2080611091","https://openalex.org/W2922809127","https://openalex.org/W1909546612","https://openalex.org/W1599287250","https://openalex.org/W4206753931","https://openalex.org/W2002769233"],"abstract_inverted_index":{"Presynaptic":[0],"vesicular":[1],"release":[2,23,58,74,90,164,180],"of":[3,16,39,52,72,88,117,147,172],"neurotransmitters":[4,22],"is":[5,60,75],"a":[6,25,105],"stochastic":[7],"process":[8],"involving":[9],"complex":[10],"mechanisms":[11,20],"triggered":[12],"by":[13,166],"an":[14],"elevation":[15],"calcium":[17],"concentration.":[18],"The":[19],"behind":[21],"play":[24],"critical":[26],"role":[27],"in":[28,37],"synaptic":[29,53,188],"function":[30],"and":[31,42,131,182],"plasticity.":[32,54,189],"Understanding":[33],"its":[34,40,43],"properties,":[35,153],"both":[36],"term":[38],"dynamics":[41,59,123,181],"underlying":[44],"mechanisms,":[45],"may":[46,156,175],"therefore":[47],"help":[48],"further":[49,177,183],"our":[50,184],"understanding":[51,186],"However,":[55,80],"measuring":[56],"vesicle":[57,73,118],"experimentally":[61],"challenging.":[62],"One":[63],"experimental":[64],"protocol":[65],"used":[66],"to":[67,76,103,112,125,144],"determine":[68],"the":[69,89,94,97,114,122,133,150,158,170],"dynamic":[70],"properties":[71,87,116],"measure":[77],"postsynaptic":[78,98,129,148,173],"current.":[79],"this":[81],"method":[82],"inherently":[83],"not":[84],"only":[85],"captures":[86],"itself,":[91],"but":[92],"also":[93],"contributions":[95,171],"from":[96,121],"receptors.":[99],"Here":[100],"we":[101],"propose":[102],"use":[104],"synapse":[106],"simulation":[107],"platform":[108],"known":[109,124],"as":[110],"EONS/RHENOMS":[111],"capture":[113],"functional":[115],"release,":[119],"separate":[120],"be":[126],"associated":[127],"with":[128,135],"receptors,":[130],"compare":[132],"results":[134,161],"those":[136],"determined":[137],"experimentally.":[138],"We":[139],"find":[140],"that":[141],"despite":[142],"attempts":[143],"reduce":[145],"interference":[146],"dynamics,":[149],"receptor":[151],"channel":[152],"particularly":[154],"desensitization,":[155],"influence":[157],"overall":[159,185],"measured":[160],"significantly.":[162],"Re-estimating":[163],"rate":[165],"taking":[167],"into":[168,179],"account":[169],"receptors":[174],"give":[176],"insight":[178],"on":[187]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}