{"id":"https://openalex.org/W2318461496","doi":"https://doi.org/10.1109/embc.2014.6943630","title":"Effects of carbon nanotube and conducting polymer coated microelectrodes on single-unit recordings in vitro","display_name":"Effects of carbon nanotube and conducting polymer coated microelectrodes on single-unit recordings in vitro","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2318461496","doi":"https://doi.org/10.1109/embc.2014.6943630","mag":"2318461496","pmid":"https://pubmed.ncbi.nlm.nih.gov/25569998"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6943630","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009803882","display_name":"Hamid Charkhkar","orcid":"https://orcid.org/0000-0001-5485-5969"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid Charkhkar","raw_affiliation_strings":["Department of Electrical Engineering, George Mason University, Fairfax, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, George Mason University, Fairfax, VA, USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087884031","display_name":"Gretchen L. Knaack","orcid":null},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gretchen L. Knaack","raw_affiliation_strings":["Department of Molecular Neuroscience, George Mason University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neuroscience, George Mason University","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051105321","display_name":"Himadri Mandal","orcid":null},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Himadri S. Mandal","raw_affiliation_strings":["George Mason University Antonin Scalia Law School, Arlington, VA, US"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"George Mason University Antonin Scalia Law School, Arlington, VA, US","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049091840","display_name":"Edward W. Keefer","orcid":"https://orcid.org/0000-0002-0470-9186"},"institutions":[{"id":"https://openalex.org/I4210100223","display_name":"Plexon (United States)","ror":"https://ror.org/013rrw978","country_code":"US","type":"company","lineage":["https://openalex.org/I4210100223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward W. Keefer","raw_affiliation_strings":["Plexon Inc., Dallas, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plexon Inc., Dallas, Texas, USA","institution_ids":["https://openalex.org/I4210100223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007738452","display_name":"Joseph J. Pancrazio","orcid":"https://orcid.org/0000-0001-8276-3690"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph J. Pancrazio","raw_affiliation_strings":["Bioengineering Department, George Mason University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Department, George Mason University","institution_ids":["https://openalex.org/I162714631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.653,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.82295989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"37","issue":null,"first_page":"469","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10660","display_name":"Conducting polymers and applications","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microelectrode","display_name":"Microelectrode","score":0.9775376319885254},{"id":"https://openalex.org/keywords/pedot-pss","display_name":"PEDOT:PSS","score":0.7999141216278076},{"id":"https://openalex.org/keywords/multielectrode-array","display_name":"Multielectrode array","score":0.711280882358551},{"id":"https://openalex.org/keywords/carbon-nanotube","display_name":"Carbon nanotube","score":0.6736658811569214},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.6705653071403503},{"id":"https://openalex.org/keywords/conductive-polymer","display_name":"Conductive polymer","score":0.5363065004348755},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.45438137650489807},{"id":"https://openalex.org/keywords/polymer","display_name":"Polymer","score":0.4460408389568329},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.38670939207077026},{"id":"https://openalex.org/keywords/electrode","display_name":"Electrode","score":0.3599448800086975},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.33764833211898804},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.22191926836967468},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.09965348243713379},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.05996045470237732}],"concepts":[{"id":"https://openalex.org/C111670793","wikidata":"https://www.wikidata.org/wiki/Q16979465","display_name":"Microelectrode","level":3,"score":0.9775376319885254},{"id":"https://openalex.org/C170029824","wikidata":"https://www.wikidata.org/wiki/Q421690","display_name":"PEDOT:PSS","level":3,"score":0.7999141216278076},{"id":"https://openalex.org/C95967509","wikidata":"https://www.wikidata.org/wiki/Q1952355","display_name":"Multielectrode array","level":4,"score":0.711280882358551},{"id":"https://openalex.org/C513720949","wikidata":"https://www.wikidata.org/wiki/Q1778729","display_name":"Carbon nanotube","level":2,"score":0.6736658811569214},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6705653071403503},{"id":"https://openalex.org/C133495861","wikidata":"https://www.wikidata.org/wiki/Q412798","display_name":"Conductive polymer","level":3,"score":0.5363065004348755},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.45438137650489807},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4460408389568329},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38670939207077026},{"id":"https://openalex.org/C17525397","wikidata":"https://www.wikidata.org/wiki/Q176140","display_name":"Electrode","level":2,"score":0.3599448800086975},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33764833211898804},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22191926836967468},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09965348243713379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.05996045470237732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011108","descriptor_name":"Polymers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037742","descriptor_name":"Nanotubes, Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037742","descriptor_name":"Nanotubes, Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D037742","descriptor_name":"Nanotubes, Carbon","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6943630","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943630","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25569998","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25569998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1964380577","https://openalex.org/W1981335504","https://openalex.org/W1993560865","https://openalex.org/W1999467897","https://openalex.org/W2003251001","https://openalex.org/W2011919971","https://openalex.org/W2017301392","https://openalex.org/W2029592532","https://openalex.org/W2031930458","https://openalex.org/W2037287583","https://openalex.org/W2037963276","https://openalex.org/W2040818707","https://openalex.org/W2042605645","https://openalex.org/W2046064055","https://openalex.org/W2051695641","https://openalex.org/W2057005089","https://openalex.org/W2061227590","https://openalex.org/W2061877343","https://openalex.org/W2066597324","https://openalex.org/W2067127980","https://openalex.org/W2075721082","https://openalex.org/W2078566930","https://openalex.org/W2079316730","https://openalex.org/W2085928275","https://openalex.org/W2101335573","https://openalex.org/W2138715030","https://openalex.org/W2140480932","https://openalex.org/W2142998520","https://openalex.org/W2144248542","https://openalex.org/W2162403802","https://openalex.org/W2163327405","https://openalex.org/W2168728912","https://openalex.org/W2172249996","https://openalex.org/W6672174992"],"related_works":["https://openalex.org/W2061877343","https://openalex.org/W2028205923","https://openalex.org/W2381760774","https://openalex.org/W2037345099","https://openalex.org/W4386697944","https://openalex.org/W1972513709","https://openalex.org/W2768056422","https://openalex.org/W2417316355","https://openalex.org/W2162019548","https://openalex.org/W2354662944"],"abstract_inverted_index":{"Neuronal":[0],"networks":[1,172],"cultured":[2,96],"on":[3,97],"microelectrode":[4,50,69],"arrays":[5],"(MEAs)":[6],"have":[7],"been":[8,39],"utilized":[9],"as":[10,119,135],"biosensors":[11],"that":[12,131,170,188],"can":[13],"detect":[14],"all":[15],"or":[16,21,32,83,181],"nothing":[17],"extracellular":[18,44],"action":[19],"potentials,":[20],"spikes.":[22],"Coating":[23],"the":[24,60,98,108,132,152,156],"microelectrodes":[25,112,138,149,168],"with":[26,34,77,139],"carbon":[27],"nanotubes":[28],"(CNTs),":[29],"either":[30,78],"pristine":[31],"conjugated":[33],"a":[35,84],"conductive":[36],"polymer,":[37,80],"has":[38],"previously":[40],"reported":[41],"to":[42,58,100,151,196],"improve":[43],"recordings":[45],"presumably":[46],"via":[47],"reduction":[48],"in":[49,65,71,194],"impedance.":[51],"The":[52,105],"goal":[53],"of":[54,62,70,86,107,137,179],"this":[55],"work":[56],"was":[57,74,93,113,142],"examine":[59],"basis":[61],"such":[63,118],"improvement":[64],"vitro.":[66],"Every":[67],"other":[68],"vitro":[72],"MEAs":[73,99],"electrochemically":[75],"modified":[76,109,148,165,197],"conducting":[79],"poly-3,4-ethylenedioxythiophene":[81],"(PEDOT)":[82],"blend":[85],"CNT":[87],"and":[88,95,110,126,159,166],"PEDOT.":[89],"Mouse":[90],"cortical":[91],"tissue":[92],"dissociated":[94],"form":[101],"functional":[102],"neuronal":[103,140,171,189],"networks.":[104],"performance":[106],"unmodified":[111,153,167],"evaluated":[114],"by":[115,145,177],"activity":[116],"measures":[117],"spike":[120,122,157],"rate,":[121],"amplitude,":[123],"burst":[124,127,160],"duration":[125],"rate.":[128],"We":[129],"observed":[130],"yield,":[133],"defined":[134],"percentage":[136],"activity,":[141],"significantly":[143],"higher":[144],"55%":[146],"for":[147,164],"compared":[150],"sites.":[154],"However,":[155],"rate":[158],"parameters":[161],"were":[162,173,191],"similar":[163],"suggesting":[169],"not":[174],"physiologically":[175],"altered":[176],"presence":[178],"PEDOT":[180],"PEDOT-CNT.":[182],"Our":[183],"observations":[184],"from":[185],"immunocytochemistry":[186],"indicated":[187],"cells":[190],"more":[192],"abundant":[193],"proximity":[195],"microelectrodes.":[198]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}