{"id":"https://openalex.org/W2325417819","doi":"https://doi.org/10.1109/embc.2014.6943588","title":"Specifying informative experiment stimulation conditions for resolving dynamical uncertainty in biological systems","display_name":"Specifying informative experiment stimulation conditions for resolving dynamical uncertainty in biological systems","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2325417819","doi":"https://doi.org/10.1109/embc.2014.6943588","mag":"2325417819","pmid":"https://pubmed.ncbi.nlm.nih.gov/25569956"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6943588","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943588","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006849228","display_name":"Thembi Mdluli","orcid":"https://orcid.org/0000-0003-3980-7736"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thembi Mdluli","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070081407","display_name":"Michael Pargett","orcid":"https://orcid.org/0000-0002-1403-7408"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Pargett","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020010248","display_name":"Gregery T. Buzzard","orcid":"https://orcid.org/0000-0001-9777-3090"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregery T. Buzzard","raw_affiliation_strings":["Department of Mathematics, Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048545593","display_name":"Ann E. Rundell","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann E. Rundell","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":2.204,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.89367198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"153 4","issue":null,"first_page":"298","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10928","display_name":"Probabilistic and Robust Engineering Design","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1804","display_name":"Statistics, Probability and Uncertainty"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9927999973297119,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6276572942733765},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5540852546691895},{"id":"https://openalex.org/keywords/grid","display_name":"Grid","score":0.47801411151885986},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.4661606252193451},{"id":"https://openalex.org/keywords/dynamical-systems-theory","display_name":"Dynamical systems theory","score":0.4487334191799164},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.42415809631347656},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.25264161825180054},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18007570505142212}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6276572942733765},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5540852546691895},{"id":"https://openalex.org/C187691185","wikidata":"https://www.wikidata.org/wiki/Q2020720","display_name":"Grid","level":2,"score":0.47801411151885986},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4661606252193451},{"id":"https://openalex.org/C79379906","wikidata":"https://www.wikidata.org/wiki/Q3174497","display_name":"Dynamical systems theory","level":2,"score":0.4487334191799164},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.42415809631347656},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.25264161825180054},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18007570505142212},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6943588","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943588","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25569956","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25569956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6899999976158142,"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1502161641","https://openalex.org/W1608485106","https://openalex.org/W1965107569","https://openalex.org/W2019143734","https://openalex.org/W2034598721","https://openalex.org/W2036407535","https://openalex.org/W2039284810","https://openalex.org/W2045534984","https://openalex.org/W2068711229","https://openalex.org/W2100560953","https://openalex.org/W2124630954","https://openalex.org/W2146888637","https://openalex.org/W2155673552","https://openalex.org/W2166565152","https://openalex.org/W6630045443"],"related_works":["https://openalex.org/W1982160337","https://openalex.org/W1971380437","https://openalex.org/W1983548084","https://openalex.org/W2141691317","https://openalex.org/W2110846987","https://openalex.org/W2160609742","https://openalex.org/W2979526210","https://openalex.org/W1997414638","https://openalex.org/W2031091109","https://openalex.org/W2049254832"],"abstract_inverted_index":{"A":[0],"computationally":[1,82],"efficient":[2],"model-based":[3],"design":[4,36,55],"of":[5,40,62,67,89,142],"experiments":[6],"(MBDOE)":[7],"strategy":[8,26,144],"is":[9,27,80],"developed":[10],"to":[11,57,71,112,122],"plan":[12],"an":[13],"optimal":[14,131],"experiment":[15,54],"by":[16,84],"specifying":[17],"the":[18,34,53,60,65,68,90,95,100,114,124,130,140],"experimental":[19,35,103],"stimulation":[20],"magnitudes":[21,127],"and":[22,43,108,128,135],"measurement":[23,133],"points.":[24,45,137],"The":[25,77],"extended":[28],"from":[29],"previous":[30],"work":[31],"which":[32,99],"optimized":[33],"over":[37],"a":[38,86,146],"space":[39],"measurable":[41],"species":[42,134],"time":[44,96,136],"We":[46,138],"include":[47],"system":[48,75],"inputs":[49],"(stimulation":[50],"conditions)":[51],"in":[52,74],"search":[56],"investigate":[58],"if":[59],"addition":[61],"perturbations":[63,104],"enhances":[64],"ability":[66],"MBDOE":[69,78],"method":[70],"resolve":[72],"uncertainties":[73],"dynamics.":[76],"problem":[79],"made":[81],"tractable":[83],"using":[85],"sparse-grid":[87],"approximation":[88],"model":[91],"output":[92],"dynamics,":[93],"pre-specifying":[94],"points":[97],"at":[98],"input":[101,126],"or":[102],"can":[105],"be":[106],"applied,":[107],"creating":[109],"scenario":[110,118],"trees":[111,119],"explore":[113],"endogenous":[115],"uncertainty.":[116],"Consecutive":[117],"are":[120],"used":[121],"determine":[123],"best":[125],"select":[129],"associated":[132],"demonstrate":[139],"effectiveness":[141],"this":[143],"on":[145],"T-Cell":[147],"Receptor":[148],"(TCR)":[149],"signaling":[150],"pathway":[151],"model.":[152]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-08-08T07:41:36.138363","created_date":"2016-06-24T00:00:00"}
