{"id":"https://openalex.org/W2320377297","doi":"https://doi.org/10.1109/embc.2014.6943579","title":"Automated analysis of respiratory behavior for the prediction of apnea in infants following general anesthesia","display_name":"Automated analysis of respiratory behavior for the prediction of apnea in infants following general anesthesia","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2320377297","doi":"https://doi.org/10.1109/embc.2014.6943579","mag":"2320377297","pmid":"https://pubmed.ncbi.nlm.nih.gov/25569947"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6943579","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001536726","display_name":"Carlos Rubio\u2010Terres","orcid":"https://orcid.org/0000-0001-5106-2912"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Carlos A. Robles-Rubio","raw_affiliation_strings":["Department of Biomedical Engineering, McGill University, Montreal, QC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101618870","display_name":"Karen A. Brown","orcid":"https://orcid.org/0000-0002-8093-844X"},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen A. Brown","raw_affiliation_strings":["Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031895447","display_name":"Gianluca Bertolizio","orcid":"https://orcid.org/0000-0001-6585-5809"},"institutions":[{"id":"https://openalex.org/I2801766832","display_name":"McGill University Health Centre","ror":"https://ror.org/04cpxjv19","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801766832"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gianluca Bertolizio","raw_affiliation_strings":["Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesia, McGill University Health Center, Montreal, QC, Canada","institution_ids":["https://openalex.org/I2801766832"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024458992","display_name":"Robert E. Kearney","orcid":"https://orcid.org/0000-0002-5107-6190"},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Robert E. Kearney","raw_affiliation_strings":["Department of Biomedical Engineering, McGill University, Montreal, QC, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, McGill University, Montreal, QC, Canada","institution_ids":["https://openalex.org/I5023651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001536726"],"corresponding_institution_ids":["https://openalex.org/I5023651"],"apc_list":null,"apc_paid":null,"fwci":0.7695,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.7406352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2014","issue":null,"first_page":"262","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apnea","display_name":"Apnea","score":0.6807565689086914},{"id":"https://openalex.org/keywords/respiratory-system","display_name":"Respiratory system","score":0.5735524296760559},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5314936637878418},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.5266889333724976},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41063210368156433},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.39177176356315613},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18520992994308472}],"concepts":[{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.6807565689086914},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5735524296760559},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5314936637878418},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5266889333724976},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41063210368156433},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.39177176356315613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18520992994308472}],"mesh":[{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000768","descriptor_name":"Anesthesia, General","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001049","descriptor_name":"Apnea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001331","descriptor_name":"Automation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008991","descriptor_name":"Monitoring, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2014.6943579","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25569947","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25569947","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.4699999988079071},{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.4300000071525574}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W252666859","https://openalex.org/W1540089290","https://openalex.org/W1975879668","https://openalex.org/W2028437942","https://openalex.org/W2029745943","https://openalex.org/W2034223928","https://openalex.org/W2050167613","https://openalex.org/W2071416102","https://openalex.org/W2085426858","https://openalex.org/W2106144946","https://openalex.org/W2127218421","https://openalex.org/W2150848236","https://openalex.org/W2170059033","https://openalex.org/W2170319267","https://openalex.org/W2290195878","https://openalex.org/W2329143515","https://openalex.org/W2485201285","https://openalex.org/W2884525847","https://openalex.org/W4252684946","https://openalex.org/W4285719527","https://openalex.org/W6632620156","https://openalex.org/W6678914141"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W1882619789"],"abstract_inverted_index":{"Infants":[0],"recovering":[1],"from":[2],"general":[3],"anesthesia":[4],"are":[5,39],"at":[6,66,192],"risk":[7,68,193],"of":[8,51,60,86,103,114,128,139,165,173,190,194],"postoperative":[9,53],"apnea":[10,42],"(POA),":[11],"a":[12,47,101,106,158,163,171,182],"potentially":[13],"life":[14],"threatening":[15],"event.":[16],"There":[17],"is":[18],"no":[19],"accurate":[20],"way":[21],"to":[22,82,96,123],"identify":[23],"which":[24],"infants":[25,32,65,191],"will":[26],"experience":[27],"POA,":[28],"and":[29,98,130,135,142,148,170],"thus":[30],"all":[31],"with":[33,100,109,162],"postmenstrual":[34],"age":[35,67],"<;":[36],"60":[37],"weeks":[38],"monitored":[40],"for":[41,69,76,185],"in":[43,63],"hospital":[44],"postoperatively.":[45],"Using":[46],"comprehensive,":[48],"automated":[49],"analysis":[50,155],"the":[52,58,73,84,87,110,125,136,146,186],"breathing":[54],"patterns,":[55],"we":[56],"identified":[57],"occurrence":[59],"respiratory":[61,89],"pauses":[62],"24":[64],"POA.":[70,195],"We":[71],"determined":[72],"POA":[74,119],"category":[75],"each":[77],"infant":[78],"by":[79],"using":[80],"K-medoids":[81,117],"cluster":[83],"duration":[85],"longest":[88],"pause.":[90],"Two":[91],"clusters":[92],"were":[93,121],"identified,":[94],"corresponding":[95],"APNEA":[97,147],"NO-APNEA,":[99],"threshold":[102,113],"14.6":[104],"s,":[105],"value":[107],"consistent":[108],"clinically":[111],"accepted":[112],"15":[115],"s.":[116],"derived":[118],"labels":[120],"used":[122],"evaluate":[124],"predictive":[126],"ability":[127],"demographic":[129],"anesthetic":[131],"management":[132],"variables.":[133],"Weight":[134],"intraoperative":[137],"doses":[138],"atropine,":[140],"propofol,":[141],"opioids":[143],"discriminated":[144],"between":[145],"NO-APNEA":[149],"groups.":[150],"A":[151],"linear":[152],"Gaussian":[153],"discriminant":[154],"classifier":[156],"provided":[157],"very":[159],"good":[160],"classification":[161],"probability":[164,172],"detection":[166],"PD":[167],"=":[168,177],"0.73":[169],"false":[174],"alarm":[175],"PFA":[176],"0.22.":[178],"This":[179],"approach":[180],"provides":[181],"promising":[183],"tool":[184],"systematic,":[187],"objective":[188],"study":[189]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-17T18:11:37.981687","created_date":"2025-10-10T00:00:00"}