{"id":"https://openalex.org/W2334035293","doi":"https://doi.org/10.1109/embc.2014.6943564","title":"Three-dimensional vascular smooth muscle orientation as quantitatively assessed by multiphoton microscopy: Mouse carotid arteries do show a helix","display_name":"Three-dimensional vascular smooth muscle orientation as quantitatively assessed by multiphoton microscopy: Mouse carotid arteries do show a helix","publication_year":2014,"publication_date":"2014-08-01","ids":{"openalex":"https://openalex.org/W2334035293","doi":"https://doi.org/10.1109/embc.2014.6943564","mag":"2334035293","pmid":"https://pubmed.ncbi.nlm.nih.gov/25569932"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2014.6943564","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943564","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018930557","display_name":"Bart Spronck","orcid":"https://orcid.org/0000-0003-1076-1922"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart Spronck","raw_affiliation_strings":["Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049105192","display_name":"Remco T. A. Megens","orcid":"https://orcid.org/0000-0001-9871-6696"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Remco T. A. Megens","raw_affiliation_strings":["Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051441299","display_name":"Koen D. Reesink","orcid":"https://orcid.org/0000-0003-2354-883X"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Koen D. Reesink","raw_affiliation_strings":["Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080175953","display_name":"Tammo Delhaas","orcid":"https://orcid.org/0000-0001-6897-9700"},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tammo Delhaas","raw_affiliation_strings":["Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I34352273"],"apc_list":null,"apc_paid":null,"fwci":2.402,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.89855658,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"31","issue":null,"first_page":"202","last_page":"205"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9532999992370605,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.6273969411849976},{"id":"https://openalex.org/keywords/orientation","display_name":"Orientation (vector space)","score":0.6161446571350098},{"id":"https://openalex.org/keywords/carotid-arteries","display_name":"Carotid arteries","score":0.508220911026001},{"id":"https://openalex.org/keywords/artery","display_name":"Artery","score":0.5030075907707214},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.48175621032714844},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"Vascular smooth muscle","score":0.4144558012485504},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3976190388202667},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.35338157415390015},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.3047249913215637},{"id":"https://openalex.org/keywords/smooth-muscle","display_name":"Smooth muscle","score":0.29998883605003357},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23091727495193481},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12737783789634705},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1164785623550415}],"concepts":[{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6273969411849976},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.6161446571350098},{"id":"https://openalex.org/C2987047532","wikidata":"https://www.wikidata.org/wiki/Q214275","display_name":"Carotid arteries","level":2,"score":0.508220911026001},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.5030075907707214},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.48175621032714844},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.4144558012485504},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3976190388202667},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.35338157415390015},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.3047249913215637},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.29998883605003357},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23091727495193481},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12737783789634705},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1164785623550415},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002339","descriptor_name":"Carotid Arteries","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036641","descriptor_name":"Microscopy, Fluorescence, Multiphoton","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2014.6943564","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2014.6943564","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:25569932","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25569932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/cab0032f-757c-48e9-a8ec-af66ba1a3989","is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/cab0032f-757c-48e9-a8ec-af66ba1a3989","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Spronck, B, Megens, R T A, Reesink, K D & Delhaas, T 2014, 'Three-dimensional vascular smooth muscle orientation as quantitatively assessed by multiphoton microscopy : mouse carotid arteries do show a helix', IEEE Engineering in Medicine and Biology Society, vol. 2014, pp. 202-5. https://doi.org/10.1109/EMBC.2014.6943564","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1509918867","https://openalex.org/W1897507705","https://openalex.org/W1991376496","https://openalex.org/W1998564930","https://openalex.org/W2017921758","https://openalex.org/W2026761772","https://openalex.org/W2041675385","https://openalex.org/W2070216603","https://openalex.org/W2085421725","https://openalex.org/W2088609985","https://openalex.org/W2129534965","https://openalex.org/W2142777371","https://openalex.org/W2154074407","https://openalex.org/W2154577866","https://openalex.org/W2166739553","https://openalex.org/W2172122582","https://openalex.org/W3013267890","https://openalex.org/W4206519171","https://openalex.org/W4229954146","https://openalex.org/W4246202668"],"related_works":["https://openalex.org/W2326514070","https://openalex.org/W2379086703","https://openalex.org/W2519170767","https://openalex.org/W2109492347","https://openalex.org/W2385711485","https://openalex.org/W1967818239","https://openalex.org/W2047567403","https://openalex.org/W2347434020","https://openalex.org/W2020573901","https://openalex.org/W2389010414"],"abstract_inverted_index":{"Smooth":[0],"muscle":[1],"cells":[2],"(SMCs)":[3],"play":[4],"a":[5,33,84,132,137,166],"pivotal":[6],"role":[7],"in":[8,12,37,43,52,63,118,145,162],"regulating":[9],"vascular":[10],"tone":[11],"arteries,":[13],"and":[14,60,101,107,141,148,164,194],"are":[15,178],"therefore":[16],"an":[17],"essential":[18,179],"part":[19],"of":[20,23,41,80,86,124,185],"constitutive":[21,183],"models":[22,184],"the":[24,28,39,44,87,94,186],"artery":[25,46,187],"wall.":[26,47],"In":[27,151],"present":[29],"study,":[30],"we":[31],"developed":[32],"method":[34,72],"to":[35,75,105,115,180],"quantify":[36],"3D":[38,64],"orientation":[40,158,193],"SMCs":[42,114],"intact":[45],"We":[48,112],"stained":[49],"cell":[50],"nuclei":[51,82],"excised":[53],"mouse":[54],"carotid":[55],"arteries":[56],"mounted":[57],"between":[58],"micropipettes":[59],"imaged":[61],"these":[62,81,125],"using":[65],"two-photon":[66],"laser":[67],"scanning":[68],"microscopy.":[69],"A":[70],"clustering":[71],"was":[73],"used":[74],"identify":[76],"individual":[77],"nuclei.":[78],"Orientations":[79],"(as":[83],"representative":[85],"SMC":[88,99,127,157,192],"orientations)":[89],"were":[90,103,129],"found":[91,113],"by":[92,131,189],"calculating":[93],"inertia":[95],"matrix":[96],"eigenvectors.":[97],"Subsequently,":[98],"locations":[100],"orientations":[102,128],"converted":[104],"cylindrical":[106],"spherical":[108],"coordinate":[109],"systems,":[110],"respectively.":[111],"be":[116,160],"arranged":[117],"two":[119],"distinct":[120,167],"layers.":[121,150],"For":[122],"each":[123],"layers,":[126],"described":[130],"Bingham":[133],"distribution.":[134],"Distributions":[135],"showed":[136],"statistically":[138],"significant":[139],"helical":[140,168],"transversal":[142,172],"angular":[143],"component":[144],"both":[146],"inner":[147],"outer":[149],"conclusion,":[152],"this":[153],"study":[154],"demonstrates":[155],"that":[156],"can":[159],"quantified":[161],"3D,":[163],"shows":[165],"as":[169,171],"well":[170],"orientation.":[173],"The":[174],"acquired":[175],"distribution":[176],"data":[177],"improve":[181],"current":[182],"wall,":[188],"describing":[190],"physiological":[191],"dispersion.":[195]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}