{"id":"https://openalex.org/W2140104118","doi":"https://doi.org/10.1109/embc.2013.6610403","title":"Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control","display_name":"Combining pharmacological therapy and vaccination in Chronic Myeloid Leukemia via model predictive control","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2140104118","doi":"https://doi.org/10.1109/embc.2013.6610403","mag":"2140104118","pmid":"https://pubmed.ncbi.nlm.nih.gov/24110590"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2013.6610403","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610403","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015494107","display_name":"Marco Laurino","orcid":"https://orcid.org/0000-0003-4798-5196"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]},{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Marco Laurino","raw_affiliation_strings":["Extreme Centre, Scuola Superiore Sant'Anna, Pisa, Italy","Dept. of Surg., Med., Mol. Pathology & of Critical Area, Univ. of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Extreme Centre, Scuola Superiore Sant'Anna, Pisa, Italy","institution_ids":["https://openalex.org/I162290304"]},{"raw_affiliation_string":"Dept. of Surg., Med., Mol. Pathology & of Critical Area, Univ. of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034777409","display_name":"Maurizio Stano","orcid":null},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Stano","raw_affiliation_strings":["Department of Information Engineering (DIE), University of Pisa, Italy","Dept. of Inf. Eng. (DIE), Univ. of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering (DIE), University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dept. of Inf. Eng. (DIE), Univ. of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052608017","display_name":"Monica Betta","orcid":"https://orcid.org/0000-0002-5672-1638"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Monica Betta","raw_affiliation_strings":["Department of Information Engineering (DIE), University of Pisa, Italy","Dept. of Inf. Eng. (DIE), Univ. of Pisa, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Information Engineering (DIE), University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"Dept. of Inf. Eng. (DIE), Univ. of Pisa, Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065996977","display_name":"Gabriele Pannocchia","orcid":"https://orcid.org/0000-0002-5578-344X"},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gabriele Pannocchia","raw_affiliation_strings":["Department of Civil and Industrial Engineering, University of Pisa, Italy","[Dept. of Civil & Ind. Eng., Univ. of Pisa, Pisa, Italy]"],"affiliations":[{"raw_affiliation_string":"Department of Civil and Industrial Engineering, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]},{"raw_affiliation_string":"[Dept. of Civil & Ind. Eng., Univ. of Pisa, Pisa, Italy]","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003036303","display_name":"Alberto Landi","orcid":"https://orcid.org/0000-0002-0105-5121"},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Landi","raw_affiliation_strings":["Extreme Centre, Scuola Superiore Sant'Anna, Pisa, Italy","EXTREME Centre, Scuola Superiore Sant'Anna, Pisa, Italy"],"affiliations":[{"raw_affiliation_string":"Extreme Centre, Scuola Superiore Sant'Anna, Pisa, Italy","institution_ids":["https://openalex.org/I162290304"]},{"raw_affiliation_string":"EXTREME Centre, Scuola Superiore Sant'Anna, Pisa, Italy","institution_ids":["https://openalex.org/I162290304"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5015494107"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I162290304"],"apc_list":null,"apc_paid":null,"fwci":0.1948,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.57774228,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"341","issue":null,"first_page":"3925","last_page":"3928"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myeloid-leukemia","display_name":"Myeloid leukemia","score":0.8621116876602173},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.5861795544624329},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5372507572174072},{"id":"https://openalex.org/keywords/disease-control","display_name":"Disease control","score":0.4800506830215454},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.46825700998306274},{"id":"https://openalex.org/keywords/model-predictive-control","display_name":"Model predictive control","score":0.4302177131175995},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.3760404884815216},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3729531764984131},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22992050647735596},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.12888425588607788}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.8621116876602173},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5861795544624329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5372507572174072},{"id":"https://openalex.org/C2987315675","wikidata":"https://www.wikidata.org/wiki/Q1773974","display_name":"Disease control","level":2,"score":0.4800506830215454},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.46825700998306274},{"id":"https://openalex.org/C172205157","wikidata":"https://www.wikidata.org/wiki/Q1782962","display_name":"Model predictive control","level":3,"score":0.4302177131175995},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.3760404884815216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3729531764984131},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22992050647735596},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.12888425588607788}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015464","descriptor_name":"Leukemia, Myelogenous, Chronic, BCR-ABL Positive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2013.6610403","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610403","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:24110590","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24110590","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.872.356","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.872.356","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Gabriele_Pannocchia/publication/257601726_Combining_pharmacological_therapy_and_vaccination_in_Chronic_Myeloid_Leukemia_via_model_predictive_control/links/0c96052f246ff53783000000.pdf","raw_type":"text"},{"id":"pmh:oai:arpi.unipi.it:11568/226074","is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/226074","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1988409998","https://openalex.org/W2005151817","https://openalex.org/W2006917576","https://openalex.org/W2018734495","https://openalex.org/W2039034204","https://openalex.org/W2058564254","https://openalex.org/W2073375615","https://openalex.org/W2094556422","https://openalex.org/W2101358888","https://openalex.org/W2105336635","https://openalex.org/W2117800811","https://openalex.org/W2141802970","https://openalex.org/W2154856176","https://openalex.org/W2161408060","https://openalex.org/W2161843704","https://openalex.org/W2314938037","https://openalex.org/W6699304963"],"related_works":["https://openalex.org/W1990079087","https://openalex.org/W3202234113","https://openalex.org/W2101188133","https://openalex.org/W4248731570","https://openalex.org/W2381210024","https://openalex.org/W2060165215","https://openalex.org/W2384015130","https://openalex.org/W4285595274","https://openalex.org/W81137451","https://openalex.org/W2556120871"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"a":[3,36,66],"simulation":[4],"study":[5],"which":[6],"aims":[7],"at":[8],"optimizing":[9],"the":[10,13,21,24,27,33,40,47,54,87,91],"therapy":[11,50,58],"for":[12],"control":[14,42],"of":[15,26,35,43,49],"Chronic":[16],"Myeloid":[17],"Leukemia":[18],"according":[19],"to":[20,53],"following":[22],"objectives:":[23],"reduction":[25],"administered":[28],"drug":[29],"and":[30,39,64],"vaccine":[31],"amounts,":[32],"establishment":[34],"auto-immune":[37],"response":[38],"long-term":[41],"disease":[44],"without":[45],"reducing":[46],"effective":[48],"with":[51],"respect":[52],"full":[55],"treatment.":[56],"A":[57],"optimization":[59],"method":[60],"is":[61],"developed":[62],"defining":[63],"solving":[65],"Model":[67],"Predictive":[68],"Control":[69],"algorithm,":[70],"preceded":[71],"by":[72],"an":[73],"accurate":[74],"Initial":[75],"Guess":[76],"search":[77],"based":[78],"on":[79],"Monte-Carlo":[80],"like":[81],"approach.":[82],"Simulation":[83],"results":[84],"show":[85],"that":[86],"suggested":[88],"procedure":[89],"achieves":[90],"proposed":[92],"goals.":[93]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}