{"id":"https://openalex.org/W2134638952","doi":"https://doi.org/10.1109/embc.2013.6610365","title":"Detection of transient, regional cardiac repolarization alternans by time-frequency analysis of synthetic electrograms","display_name":"Detection of transient, regional cardiac repolarization alternans by time-frequency analysis of synthetic electrograms","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2134638952","doi":"https://doi.org/10.1109/embc.2013.6610365","mag":"2134638952","pmid":"https://pubmed.ncbi.nlm.nih.gov/24110552"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2013.6610365","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610365","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082855807","display_name":"Michele Orini","orcid":"https://orcid.org/0000-0001-5773-0344"},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["ES","GB"],"is_corresponding":false,"raw_author_name":"Michele Orini","raw_affiliation_strings":["CIBER-BBN, Zaragoza, Spain","Institute of Cardiovascular Science, University College London, London, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBER-BBN, Zaragoza, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060521948","display_name":"Ben Hanson","orcid":"https://orcid.org/0000-0003-4661-6778"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Hanson","raw_affiliation_strings":["Department of Mechanical Engineering, University College London, UK","Dept. of Mech. Eng., Univ. Coll. London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University College London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Dept. of Mech. Eng., Univ. Coll. London, London, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032336399","display_name":"Peter Taggart","orcid":null},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Taggart","raw_affiliation_strings":["Institue of Cardiovascular Science, University College London, UK","Institute of Cardiovascular Science, University College London, London, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institue of Cardiovascular Science, University College London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024316919","display_name":"Pier D. Lambiase","orcid":"https://orcid.org/0000-0002-9055-9267"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Pier Lambiase","raw_affiliation_strings":["Institue of Cardiovascular Science, University College London, UK","Institute of Cardiovascular Science, University College London, London, UK#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institue of Cardiovascular Science, University College London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Institute of Cardiovascular Science, University College London, London, UK#TAB#","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.4781,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.94453782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"99","issue":null,"first_page":"3773","last_page":"3776"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9909999966621399,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11021","display_name":"ECG Monitoring and Analysis","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-wave-alternans","display_name":"T wave alternans","score":0.9389506578445435},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.8325380086898804},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6202157735824585},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.5215722918510437},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"Sudden cardiac death","score":0.49418261647224426},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"Electrocardiography","score":0.42139557003974915},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.324271559715271},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.1715686321258545}],"concepts":[{"id":"https://openalex.org/C2777325121","wikidata":"https://www.wikidata.org/wiki/Q3613169","display_name":"T wave alternans","level":3,"score":0.9389506578445435},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.8325380086898804},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6202157735824585},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5215722918510437},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.49418261647224426},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.42139557003974915},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.324271559715271},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.1715686321258545}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001145","descriptor_name":"Arrhythmias, Cardiac","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006323","descriptor_name":"Heart Arrest","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016757","descriptor_name":"Death, Sudden, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1109/embc.2013.6610365","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610365","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:24110552","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24110552","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1400916","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1400916/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: (Proceedings) 35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC). (pp. pp. 3773-3776). IEEE (2013)","raw_type":"Proceedings paper"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1415956","is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/1415956/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: (pp. pp. 3773-3776). (2013)","raw_type":"Proceedings paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8399999737739563}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W121250741","https://openalex.org/W1442860612","https://openalex.org/W1584989479","https://openalex.org/W2018942093","https://openalex.org/W2050230904","https://openalex.org/W2071470777","https://openalex.org/W2077129671","https://openalex.org/W2102353396","https://openalex.org/W2104646655","https://openalex.org/W2133963004","https://openalex.org/W2161531776","https://openalex.org/W2170955665"],"related_works":["https://openalex.org/W2805233604","https://openalex.org/W2187428238","https://openalex.org/W1581740802","https://openalex.org/W2041363330","https://openalex.org/W2025372916","https://openalex.org/W2046243719","https://openalex.org/W2056063595","https://openalex.org/W2898950838","https://openalex.org/W2075177274","https://openalex.org/W2970223320"],"abstract_inverted_index":{"Repolarization":[0],"alternans":[1,19],"(RA),":[2],"originating":[3],"at":[4,49],"the":[5,37,43,47,50,147,154,156,161,163,168],"cellular":[6],"level,":[7],"is":[8,21],"thought":[9],"to":[10,60,85,106],"produce":[11],"an":[12,181],"arrhythmogenic":[13],"substrate,":[14],"and":[15,74,121,128,131,152],"surface":[16],"ECG":[17],"T-wave":[18],"(TWA)":[20],"a":[22,56,78,96,101,138,144],"marker":[23],"of":[24,46,68,110,116,137,150,165,175],"risk":[25],"for":[26,133],"sudden":[27],"cardiac":[28],"death.":[29],"In":[30,95],"this":[31],"paper":[32],"we":[33,76,99,171],"study":[34,61],"RA":[35,112,151,159],"in":[36,91],"unipolar":[38],"electrograms":[39],"(EGM),":[40],"which":[41,88,177],"represent":[42],"electrical":[44],"activity":[45],"heart":[48,104],"tissue":[51],"level.":[52],"We":[53],"first":[54],"describe":[55],"simple":[57],"analytical":[58],"model":[59,105],"how":[62],"RA,":[63],"simulated":[64],"as":[65],"alternating":[66],"variations":[67],"action":[69],"potential":[70],"duration,":[71],"affects":[72],"EGM-TWA,":[73],"then":[75],"propose":[77],"novel":[79],"methodology":[80],"based":[81],"on":[82],"time-frequency":[83],"analysis":[84],"detect":[86],"EGM-TWA":[87,179],"occurs":[89],"intermittently":[90],"few":[92],"consecutive":[93,135],"beats.":[94],"simulation":[97],"study,":[98],"used":[100],"257-node":[102],"whole":[103],"reproduce":[107],"several":[108],"patterns":[109],"RA.":[111],"involved":[113],"specific":[114],"subsets":[115],"adjacent":[117],"nodes":[118],"(11,":[119],"65":[120],"257),":[122],"exhibited":[123,178],"different":[124],"amplitudes":[125],"(0.25,":[126],"0.5":[127],"1":[129],"ms)":[130],"lasted":[132],"40":[134],"beats":[136],"80-beat-long":[139],"test":[140],"sequence.":[141],"Results":[142],"show":[143],"relationship":[145],"between":[146],"spatial":[148],"distribution":[149],"EGM-TWA:":[153],"smaller":[155],"region":[157],"where":[158],"occurs,":[160],"higher":[162,183],"extent":[164],"EGM-TWA.":[166],"With":[167],"proposed":[169],"methodology,":[170],"localized":[172],"those":[173],"portions":[174],"myocardium":[176],"with":[180],"accuracy":[182],"than":[184],"90%.":[185]},"counts_by_year":[{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}