{"id":"https://openalex.org/W2081966445","doi":"https://doi.org/10.1109/embc.2013.6610338","title":"Robust classification of DNA damage patterns in single cell gel electrophoresis","display_name":"Robust classification of DNA damage patterns in single cell gel electrophoresis","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2081966445","doi":"https://doi.org/10.1109/embc.2013.6610338","mag":"2081966445","pmid":"https://pubmed.ncbi.nlm.nih.gov/24110525"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2013.6610338","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610338","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035038702","display_name":"Tae\u2010Hoon Lee","orcid":"https://orcid.org/0000-0003-0105-1750"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Taehoon Lee","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100708049","display_name":"Sungmin Lee","orcid":"https://orcid.org/0000-0003-2096-4029"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungmin Lee","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006414460","display_name":"Woo\u2010Young Sim","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Woo Young Sim","raw_affiliation_strings":["Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","Res. Div., NanoEnTek Inc., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","institution_ids":[]},{"raw_affiliation_string":"Res. Div., NanoEnTek Inc., Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027135476","display_name":"Yu Mi Jung","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yu Mi Jung","raw_affiliation_strings":["Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","Res. Div., NanoEnTek Inc., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","institution_ids":[]},{"raw_affiliation_string":"Res. Div., NanoEnTek Inc., Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101037047","display_name":"Sunmi Han","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunmi Han","raw_affiliation_strings":["Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","Res. Div., NanoEnTek Inc., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","institution_ids":[]},{"raw_affiliation_string":"Res. Div., NanoEnTek Inc., Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103529481","display_name":"Chanil Chung","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chanil Chung","raw_affiliation_strings":["Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","Res. Div., NanoEnTek Inc., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","institution_ids":[]},{"raw_affiliation_string":"Res. Div., NanoEnTek Inc., Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008919941","display_name":"Jay Junkeun Chang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jay Junkeun Chang","raw_affiliation_strings":["Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","Res. Div., NanoEnTek Inc., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Research Division, NanoEnTek Inc., Guro-gu, Seoul, Korea","institution_ids":[]},{"raw_affiliation_string":"Res. Div., NanoEnTek Inc., Seoul, South Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101764096","display_name":"Hyeyoung Min","orcid":"https://orcid.org/0000-0002-7964-2924"},"institutions":[{"id":"https://openalex.org/I67900169","display_name":"Chung-Ang University","ror":"https://ror.org/01r024a98","country_code":"KR","type":"education","lineage":["https://openalex.org/I67900169"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyeyoung Min","raw_affiliation_strings":["College of Pharmacy, Chung-Ang University, Seoul, Korea","College of Pharmacy, Chung-Ang University, Seoul South Korea"],"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chung-Ang University, Seoul, Korea","institution_ids":["https://openalex.org/I67900169"]},{"raw_affiliation_string":"College of Pharmacy, Chung-Ang University, Seoul South Korea","institution_ids":["https://openalex.org/I67900169"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086877012","display_name":"Sungroh Yoon","orcid":"https://orcid.org/0000-0002-2367-197X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sungroh Yoon","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea","institution_ids":["https://openalex.org/I139264467"]},{"raw_affiliation_string":"Dept. of Electr. & Comput. Eng., Seoul Nat. Univ., Seoul, South Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5035038702"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.06009922,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2013","issue":null,"first_page":"3666","last_page":"3669"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comet-assay","display_name":"Comet assay","score":0.7979285717010498},{"id":"https://openalex.org/keywords/comet","display_name":"Comet","score":0.6692544221878052},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.6473400592803955},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5943436622619629},{"id":"https://openalex.org/keywords/gel-electrophoresis","display_name":"Gel electrophoresis","score":0.5658074617385864},{"id":"https://openalex.org/keywords/genotoxicity","display_name":"Genotoxicity","score":0.5549943447113037},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.4863949120044708},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4359324872493744},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4165460765361786},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.38362550735473633},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.28043484687805176},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21213829517364502},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.21126580238342285},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.11892503499984741}],"concepts":[{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.7979285717010498},{"id":"https://openalex.org/C94081185","wikidata":"https://www.wikidata.org/wiki/Q3559","display_name":"Comet","level":2,"score":0.6692544221878052},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.6473400592803955},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5943436622619629},{"id":"https://openalex.org/C116084860","wikidata":"https://www.wikidata.org/wiki/Q48255","display_name":"Gel electrophoresis","level":2,"score":0.5658074617385864},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.5549943447113037},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4863949120044708},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4359324872493744},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4165460765361786},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.38362550735473633},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28043484687805176},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21213829517364502},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.21126580238342285},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11892503499984741},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007091","descriptor_name":"Image Processing, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020552","descriptor_name":"Comet Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2013.6610338","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2013.6610338","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)","raw_type":"proceedings-article"},{"id":"pmid:24110525","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24110525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1964896880","https://openalex.org/W1982602899","https://openalex.org/W1995920508","https://openalex.org/W2006327073","https://openalex.org/W2032607445","https://openalex.org/W2033849769","https://openalex.org/W2034485370","https://openalex.org/W2105035676","https://openalex.org/W2145023731","https://openalex.org/W2161160262"],"related_works":["https://openalex.org/W2111916114","https://openalex.org/W2327748090","https://openalex.org/W1985401126","https://openalex.org/W2125435889","https://openalex.org/W2082617406","https://openalex.org/W2010127944","https://openalex.org/W2209591937","https://openalex.org/W2582733893","https://openalex.org/W2574549984","https://openalex.org/W1967709023"],"abstract_inverted_index":{"Single":[0],"cell":[1],"gel":[2],"electrophoresis,":[3],"also":[4],"known":[5],"as":[6,41],"comet":[7,72],"assay,":[8],"has":[9],"been":[10],"widely":[11],"used":[12],"for":[13,32,70],"assessing":[14],"the":[15],"effect":[16],"of":[17,23,55],"genotoxicity":[18],"and":[19,47,58,81,101],"detecting":[20],"DNA":[21,78],"damage":[22,79],"individual":[24],"eukaryotic":[25],"cells.":[26],"There":[27],"exist":[28],"established":[29],"imaging":[30],"techniques":[31],"cometassay":[33],"analysis,":[34],"but":[35],"these":[36],"platforms":[37],"have":[38],"limitations":[39],"such":[40],"required":[42],"user":[43],"interventions,":[44],"low":[45],"throughput,":[46],"weakness":[48],"to":[49],"noise":[50],"caused":[51],"by":[52],"incomplete":[53],"dyeing":[54],"fluorescent":[56],"materials":[57],"other":[59],"experimental":[60],"errors.":[61],"To":[62],"resolve":[63],"these,":[64],"we":[65],"propose":[66],"a":[67,85],"novel":[68],"procedure":[69],"analyzing":[71],"assay":[73],"images,":[74],"which":[75],"considers":[76],"various":[77],"patterns":[80],"classifies":[82],"them":[83],"in":[84],"robust":[86],"manner.":[87],"We":[88],"tested":[89],"our":[90],"approach":[91],"with":[92],"twenty":[93],"golden":[94],"data":[95],"sets":[96],"containing":[97],"over":[98],"300":[99],"comets":[100],"achieved":[102],"satisfactory":[103],"classification":[104],"accuracy.":[105]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}