{"id":"https://openalex.org/W2136109061","doi":"https://doi.org/10.1109/embc.2012.6347512","title":"A computational multiscale model of glioblastoma growth: Regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK","display_name":"A computational multiscale model of glioblastoma growth: Regulation of cell migration and proliferation via microRNA-451, LKB1 and AMPK","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2136109061","doi":"https://doi.org/10.1109/embc.2012.6347512","mag":"2136109061","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367447"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347512","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010066068","display_name":"Tina A. Schuetz","orcid":null},"institutions":[{"id":"https://openalex.org/I4210092939","display_name":"Institute for Integrative and Experimental Genomics","ror":"https://ror.org/00fy7kr67","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210092939"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. A. Schuetz","raw_affiliation_strings":["Institute of Medical Engineering, University of Luebeck, 23562 Luebeck, Germany. fschuetz@imt.uni-luebeck.de","Institute of Medical Engineering, University of Luebeck, 23562, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562 Luebeck, Germany. fschuetz@imt.uni-luebeck.de","institution_ids":["https://openalex.org/I4210092939","https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054589273","display_name":"Stefan Becker","orcid":"https://orcid.org/0000-0002-5333-3162"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S. Becker","raw_affiliation_strings":["Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","Institute of Medical Engineering, University of Luebeck, 23562, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017333493","display_name":"Andreas Mang","orcid":"https://orcid.org/0000-0003-4605-3290"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Mang","raw_affiliation_strings":["Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","Institute of Medical Engineering, University of Luebeck, 23562, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038388778","display_name":"Alina Toma","orcid":"https://orcid.org/0000-0003-2212-2896"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Toma","raw_affiliation_strings":["Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","Institute of Medical Engineering, University of Luebeck, 23562, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075608266","display_name":"Thorsten M. Buzug","orcid":"https://orcid.org/0000-0002-0399-8043"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. M. Buzug","raw_affiliation_strings":["Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","Institute of Medical Engineering, University of Luebeck, 23562, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, Luebeck, Germany","institution_ids":["https://openalex.org/I9341345"]},{"raw_affiliation_string":"Institute of Medical Engineering, University of Luebeck, 23562, Germany","institution_ids":["https://openalex.org/I9341345"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0441,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75882731,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"244","issue":null,"first_page":"6620","last_page":"6623"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.7019216418266296},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6781924962997437},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.6625418663024902},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.6203610897064209},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.525144100189209},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5153836011886597},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.48268842697143555},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4613921642303467},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.40126800537109375},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2821567952632904},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.21391454339027405},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.1985274851322174},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.17093303799629211},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"Protein kinase A","score":0.1520974040031433},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07921919226646423},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07136866450309753}],"concepts":[{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7019216418266296},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6781924962997437},{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.6625418663024902},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6203610897064209},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.525144100189209},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5153836011886597},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48268842697143555},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4613921642303467},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40126800537109375},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2821567952632904},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21391454339027405},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.1985274851322174},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.17093303799629211},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.1520974040031433},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07921919226646423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07136866450309753}],"mesh":[{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091162","descriptor_name":"AMP-Activated Protein Kinase Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347512","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347512","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23367447","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367447","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1415161376","https://openalex.org/W1974034376","https://openalex.org/W1976760923","https://openalex.org/W2008316228","https://openalex.org/W2056137479","https://openalex.org/W2067122631","https://openalex.org/W2081920342","https://openalex.org/W2092375071","https://openalex.org/W2092787533","https://openalex.org/W2104010300","https://openalex.org/W2128551987","https://openalex.org/W2134138119","https://openalex.org/W2138319716","https://openalex.org/W2142171814","https://openalex.org/W2151794458","https://openalex.org/W2475574885"],"related_works":["https://openalex.org/W4323320733","https://openalex.org/W12249326","https://openalex.org/W1970339330","https://openalex.org/W2045273766","https://openalex.org/W3177222321","https://openalex.org/W2317113145","https://openalex.org/W2517461269","https://openalex.org/W2330301297","https://openalex.org/W1978986557","https://openalex.org/W2610781292"],"abstract_inverted_index":{"A":[0],"new":[1],"computational":[2,108],"multiscale":[3],"model":[4,11,15,109],"of":[5,46,54,71,89],"glioblastoma":[6,55],"growth":[7],"is":[8,37],"introduced.":[9],"This":[10],"combines":[12],"an":[13],"agent-based":[14],"for":[16,28],"representing":[17],"processes":[18],"on":[19,31,39,43,99],"the":[20,32,44,52,69,85,100,107],"cellular":[21,94],"level":[22],"with":[23],"a":[24,65,82,90,111],"molecular":[25,86],"interaction":[26,45,87],"network":[27,36,63,88],"each":[29],"cell":[30,56,92,113],"subcellular":[33],"scale.":[34],"The":[35],"based":[38],"recently":[40],"published":[41],"work":[42],"microRNA-451,":[47],"LKB1":[48],"and":[49,58],"AMPK":[50],"in":[51,119,120],"regulation":[53],"migration":[57],"proliferation.":[59],"We":[60],"translated":[61],"this":[62],"into":[64],"mathematical":[66],"description":[67],"by":[68],"use":[70],"17":[72],"ordinary":[73],"differential":[74],"equations.":[75],"In":[76],"our":[77],"model,":[78],"we":[79],"furthermore":[80],"establish":[81],"link":[83],"from":[84],"single":[91],"to":[93,116],"actions":[95],"(e.g.":[96],"chemotactic":[97],"movement)":[98],"microscopic":[101],"level.":[102],"First":[103],"results":[104],"demonstrate":[105],"that":[106,117],"reproduces":[110],"tumor":[112],"development":[114],"comparable":[115],"observed":[118],"vitro":[121],"experiments.":[122]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}