{"id":"https://openalex.org/W2065129868","doi":"https://doi.org/10.1109/embc.2012.6347511","title":"Integrating degenerative mechanisms in bone and cartilage: A multiscale approach","display_name":"Integrating degenerative mechanisms in bone and cartilage: A multiscale approach","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2065129868","doi":"https://doi.org/10.1109/embc.2012.6347511","mag":"2065129868","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367446"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347511","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347511","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023355749","display_name":"Justin Fernandez","orcid":"https://orcid.org/0000-0001-7721-8698"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Justin W. Fernandez","raw_affiliation_strings":["Auckland Bioengineering Institute, The University of Auckland, New Zealand. j.fernandez@ auckland.ac.nz","Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand. j.fernandez@ auckland.ac.nz","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000359126","display_name":"Vickie Shim","orcid":"https://orcid.org/0000-0002-1680-4287"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"V. B. Shim","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, New Zealand","Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064457425","display_name":"Peter Hunter","orcid":"https://orcid.org/0000-0001-9665-4145"},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"P. J. Hunter","raw_affiliation_strings":["Auckland Bioengineering Institute, University of Auckland, New Zealand","Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Auckland Bioengineering Institute, University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Auckland Bioengineering Institute, The University of Auckland, New Zealand, 1010","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":null,"apc_paid":null,"fwci":0.226,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.60279701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":null,"first_page":"6616","last_page":"6619"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9668999910354614,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9294000267982483,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage","display_name":"Cartilage","score":0.6676510572433472},{"id":"https://openalex.org/keywords/multiscale-modeling","display_name":"Multiscale modeling","score":0.5653291940689087},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"Bone remodeling","score":0.5016610622406006},{"id":"https://openalex.org/keywords/subchondral-bone","display_name":"Subchondral bone","score":0.4448431432247162},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4424005150794983},{"id":"https://openalex.org/keywords/degeneration","display_name":"Degeneration (medical)","score":0.4422076344490051},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.42350855469703674},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.3518552780151367},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.32914215326309204},{"id":"https://openalex.org/keywords/articular-cartilage","display_name":"Articular cartilage","score":0.2872915267944336},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.26943671703338623},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22769886255264282},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22010532021522522},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.21353232860565186},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"Osteoarthritis","score":0.2096002995967865},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1713939607143402}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.6676510572433472},{"id":"https://openalex.org/C141123601","wikidata":"https://www.wikidata.org/wiki/Q6935072","display_name":"Multiscale modeling","level":2,"score":0.5653291940689087},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.5016610622406006},{"id":"https://openalex.org/C3018615303","wikidata":"https://www.wikidata.org/wiki/Q1801229","display_name":"Subchondral bone","level":5,"score":0.4448431432247162},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4424005150794983},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4422076344490051},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.42350855469703674},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3518552780151367},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.32914215326309204},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.2872915267944336},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.26943671703338623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22769886255264282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22010532021522522},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.21353232860565186},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.2096002995967865},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1713939607143402},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000886","descriptor_name":"Anthropometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000886","descriptor_name":"Anthropometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000886","descriptor_name":"Anthropometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001862","descriptor_name":"Bone Resorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005684","descriptor_name":"Gait","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007781","descriptor_name":"Lactoferrin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008953","descriptor_name":"Models, Anatomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010024","descriptor_name":"Osteoporosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016062","descriptor_name":"Porosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016118","descriptor_name":"Anterior Cruciate Ligament","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016723","descriptor_name":"Bone Remodeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347511","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347511","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23367446","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314691","display_name":"Robertson Foundation","ror":"https://ror.org/04h2x1077"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1982329236","https://openalex.org/W1997523154","https://openalex.org/W1999589417","https://openalex.org/W2039651603","https://openalex.org/W2041517292","https://openalex.org/W2047480488","https://openalex.org/W2066536946","https://openalex.org/W2087384197","https://openalex.org/W2104904898","https://openalex.org/W2122387284","https://openalex.org/W2131645519","https://openalex.org/W2139561582","https://openalex.org/W2139687606","https://openalex.org/W2155496317"],"related_works":["https://openalex.org/W4210746753","https://openalex.org/W619208188","https://openalex.org/W2140220318","https://openalex.org/W3024285948","https://openalex.org/W2997598020","https://openalex.org/W2042659556","https://openalex.org/W2397018870","https://openalex.org/W4253557482","https://openalex.org/W2013825234","https://openalex.org/W4205281001"],"abstract_inverted_index":{"At":[0,31],"the":[1,32,61,68,88,101,161,168,172,176,184],"whole":[2,116,148,153],"organ":[3,154],"level,":[4],"degenerative":[5,29],"mechanisms":[6],"in":[7,16,22,39,45,49,126,188,192],"bone":[8,46,198],"and":[9,47,74,84,90,100,119,136,144,151,195,199],"cartilage":[10,200],"are":[11],"primarily":[12],"attributed":[13],"to":[14,54,95,128],"modifications":[15],"loading":[17],"pattern.":[18],"Either":[19],"a":[20,28,55,106,140],"change":[21],"magnitude":[23],"or":[24],"location":[25],"can":[26,114],"initiate":[27],"path.":[30],"micro":[33,89,135],"scale":[34],"we":[35,71,159],"often":[36],"see":[37],"changes":[38,52],"structure":[40],"such":[41],"as":[42,165,179],"porosity":[43],"increase":[44],"fibrillation":[48],"cartilage.":[50],"These":[51],"contribute":[53],"reduced":[56],"structural":[57],"integrity":[58],"that":[59,77],"weakens":[60],"bulk":[62,149],"strength":[63],"of":[64,167,186],"tissue.":[65],"Finally,":[66],"at":[67],"cell":[69],"level":[70,104],"have":[72],"modeling":[73,108],"remodeling":[75,187],"pathways":[76],"may":[78],"be":[79],"disrupted":[80],"through":[81,122],"disease,":[82],"drugs":[83],"altered":[85],"stimulus":[86],"from":[87],"macro":[91],"scales.":[92],"In":[93,139,156],"order":[94,127],"understand":[96,129],"this":[97,157],"entire":[98],"process":[99],"roles":[102],"each":[103],"plays":[105],"multiscale":[107,162],"framework":[109,113],"is":[110],"necessary.":[111],"This":[112],"take":[115],"body":[117],"loadings":[118],"pass":[120],"information":[121],"finer":[123],"spatial":[124],"scales":[125],"how":[130],"everyday":[131],"dynamic":[132],"movements":[133],"influence":[134,185],"cellular":[137,143],"response.":[138],"similar":[141],"manner,":[142],"microstructural":[145],"processes":[146],"regulate":[147],"properties":[150],"modify":[152],"strength.":[155],"study":[158],"highlight":[160],"links":[163],"developed":[164],"part":[166],"open-source":[169],"ontologies":[170],"for":[171],"Physiome":[173],"Project":[174],"using":[175],"lower":[177],"limb":[178],"an":[180],"example.":[181],"We":[182],"consider":[183],"(i)":[189],"anabolic":[190],"treatments":[191],"cortical":[193],"bone;":[194],"(ii)":[196],"subchondral":[197],"degeneration.":[201]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}
