{"id":"https://openalex.org/W2010597621","doi":"https://doi.org/10.1109/embc.2012.6347441","title":"A network clustering algorithm for detection of protein families","display_name":"A network clustering algorithm for detection of protein families","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2010597621","doi":"https://doi.org/10.1109/embc.2012.6347441","mag":"2010597621","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367376"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347441","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347441","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100677765","display_name":"Jiang Xie","orcid":"https://orcid.org/0000-0001-9944-8822"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jiang Xie","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China","Department of Mathematics, University of California, Irvine, Irvine, CA, USA","School of Computer Engineering and Science, Shanghai University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Shanghai 200072, China","institution_ids":["https://openalex.org/I141962983"]},{"raw_affiliation_string":"Department of Mathematics, University of California, Irvine, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075550992","display_name":"Minchao Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minchao Wang","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101914465","display_name":"Dongbo Dai","orcid":"https://orcid.org/0000-0003-1465-1990"},"institutions":[{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongbo Dai","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I141962983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020798627","display_name":"Huiran Zhang","orcid":"https://orcid.org/0000-0002-9445-8930"},"institutions":[{"id":"https://openalex.org/I141962983","display_name":"Shanghai University of Engineering Science","ror":"https://ror.org/0557b9y08","country_code":"CN","type":"education","lineage":["https://openalex.org/I141962983"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiran Zhang","raw_affiliation_strings":["School of Computer Engineering and Science, Shanghai University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I141962983"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5118983636","display_name":"Wu Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I113940042","display_name":"Shanghai University","ror":"https://ror.org/006teas31","country_code":"CN","type":"education","lineage":["https://openalex.org/I113940042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wu Zhang","raw_affiliation_strings":["School of Computer Engineering and Science, High Performance Computing Center, Shanghai University, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"School of Computer Engineering and Science, High Performance Computing Center, Shanghai University, Shanghai, China","institution_ids":["https://openalex.org/I113940042"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100677765"],"corresponding_institution_ids":["https://openalex.org/I141962983","https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":0.1313,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.50483722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"34","issue":null,"first_page":"6329","last_page":"6332"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8775640726089478},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7393472194671631},{"id":"https://openalex.org/keywords/cure-data-clustering-algorithm","display_name":"CURE data clustering algorithm","score":0.4714525640010834},{"id":"https://openalex.org/keywords/canopy-clustering-algorithm","display_name":"Canopy clustering algorithm","score":0.4639764428138733},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.4614924192428589},{"id":"https://openalex.org/keywords/correlation-clustering","display_name":"Correlation clustering","score":0.45272448658943176},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.43059390783309937},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41056448221206665},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.34934696555137634},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3218064606189728}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8775640726089478},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7393472194671631},{"id":"https://openalex.org/C33704608","wikidata":"https://www.wikidata.org/wiki/Q5014717","display_name":"CURE data clustering algorithm","level":4,"score":0.4714525640010834},{"id":"https://openalex.org/C104047586","wikidata":"https://www.wikidata.org/wiki/Q5033439","display_name":"Canopy clustering algorithm","level":4,"score":0.4639764428138733},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.4614924192428589},{"id":"https://openalex.org/C94641424","wikidata":"https://www.wikidata.org/wiki/Q5172845","display_name":"Correlation clustering","level":3,"score":0.45272448658943176},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.43059390783309937},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41056448221206665},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.34934696555137634},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3218064606189728},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347441","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347441","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23367376","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1493206838","https://openalex.org/W1967316786","https://openalex.org/W1985203726","https://openalex.org/W1995413875","https://openalex.org/W2053159677","https://openalex.org/W2097216034","https://openalex.org/W2110734043","https://openalex.org/W2121564430","https://openalex.org/W2124166542","https://openalex.org/W2143011057","https://openalex.org/W2148474327","https://openalex.org/W2154139219","https://openalex.org/W2159675211","https://openalex.org/W2161855013","https://openalex.org/W4236236547"],"related_works":["https://openalex.org/W3144143113","https://openalex.org/W3022637481","https://openalex.org/W3120229345","https://openalex.org/W3088133960","https://openalex.org/W3039964395","https://openalex.org/W2607902515","https://openalex.org/W2393707058","https://openalex.org/W2371010743","https://openalex.org/W2170078080","https://openalex.org/W2050713761"],"abstract_inverted_index":{"Detection":[0],"of":[1,30,97,140],"protein":[2,128,141],"families":[3,77,142],"in":[4,79,88,137],"large":[5],"scale":[6],"database":[7],"is":[8,67,135],"a":[9,106,145],"difficult":[10],"but":[11],"important":[12],"biological":[13],"problem.":[14,22],"Computational":[15],"clustering":[16,27,60,102],"methods":[17],"can":[18],"effectively":[19],"address":[20],"the":[21,36,44,71,89,95,98,101,122,127,133,138,149],"Although":[23],"there":[24],"exist":[25],"many":[26],"algorithms,":[28],"most":[29],"them":[31],"are":[32,41,50,113],"just":[33],"based":[34],"on":[35,100,109,126],"threshold.":[37],"Their":[38],"computational":[39],"performances":[40],"affected":[42],"by":[43,117],"weight":[45],"distribution":[46],"greatly,":[47],"and":[48,64,93,143],"they":[49],"only":[51],"valid":[52],"for":[53],"some":[54],"special":[55],"networks.":[56],"A":[57],"new":[58],"network":[59],"algorithm,":[61],"Markov":[62],"Finding":[63],"Clustering":[65],"(MFC),":[66],"proposed":[68],"to":[69,121],"cluster":[70],"proteins":[72],"into":[73],"their":[74],"functionally":[75],"specific":[76],"accurately":[78],"this":[80],"paper.":[81],"The":[82],"MFC":[83],"algorithm":[84,134],"makes":[85],"an":[86],"improvement":[87],"random":[90],"walk":[91],"process":[92],"reduces":[94],"affection":[96],"noise":[99],"result.":[103],"It":[104],"has":[105,144],"good":[107],"performance":[108,147],"these":[110],"networks":[111],"which":[112],"not":[114],"well":[115],"addressed":[116],"existing":[118],"algorithms":[119],"sensitive":[120],"noise.":[123],"Finally,":[124],"experiments":[125],"sequence":[129],"datasets":[130],"demonstrate":[131],"that":[132],"effective":[136],"detection":[139],"better":[146],"than":[148],"current":[150],"algorithms.":[151]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}