{"id":"https://openalex.org/W2048292442","doi":"https://doi.org/10.1109/embc.2012.6347268","title":"Investigation of cerebral hemodynamics and collateralization in asymptomatic carotid stenoses","display_name":"Investigation of cerebral hemodynamics and collateralization in asymptomatic carotid stenoses","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2048292442","doi":"https://doi.org/10.1109/embc.2012.6347268","mag":"2048292442","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367203"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347268","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347268","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052856350","display_name":"Khalid AlMuhanna","orcid":"https://orcid.org/0000-0002-4303-3641"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Khalid AlMuhanna","raw_affiliation_strings":["Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030, USA. kalmuha1@ gmu.edu","Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030 USA"],"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030, USA. kalmuha1@ gmu.edu","institution_ids":["https://openalex.org/I162714631"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030 USA","institution_ids":["https://openalex.org/I162714631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101437611","display_name":"Limin Zhao","orcid":"https://orcid.org/0000-0002-5968-7543"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I1315496137","display_name":"University of Maryland Medical Center","ror":"https://ror.org/00sde4n60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315496137","https://openalex.org/I14285509"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Limin Zhao","raw_affiliation_strings":["University of Maryland Medical Center, Baltimore, MD, USA","University of Maryland Medical Center, Baltimore, 21201 USA"],"affiliations":[{"raw_affiliation_string":"University of Maryland Medical Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1315496137"]},{"raw_affiliation_string":"University of Maryland Medical Center, Baltimore, 21201 USA","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I1315496137"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064533965","display_name":"Grzegorz Kowalewski","orcid":"https://orcid.org/0000-0001-7183-7711"},"institutions":[{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Kowalewski","raw_affiliation_strings":["Baltimore Veteran Affairs Medical Center, Baltimore, MD, USA","Baltimore Veteran Affairs Medical Center, Baltimore, MD 21201 USA"],"affiliations":[{"raw_affiliation_string":"Baltimore Veteran Affairs Medical Center, Baltimore, MD, USA","institution_ids":["https://openalex.org/I2799886695"]},{"raw_affiliation_string":"Baltimore Veteran Affairs Medical Center, Baltimore, MD 21201 USA","institution_ids":["https://openalex.org/I2799886695"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077106229","display_name":"Kirk W. Beach","orcid":"https://orcid.org/0000-0002-9872-8352"},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. W. Beach","raw_affiliation_strings":["Department of Surgery, Vascular Division and Department of Bioengineering, University of Washington, Seattle, WA, USA","Department of Surgery, Vascular Division, and Department of Bioengineering, University of Washington, Seattle, 98104 USA"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Vascular Division and Department of Bioengineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Surgery, Vascular Division, and Department of Bioengineering, University of Washington, Seattle, 98104 USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040412256","display_name":"Brajesh K. Lal","orcid":"https://orcid.org/0000-0001-6724-8201"},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brajesh K. Lal","raw_affiliation_strings":["Center for Vascular Diagnostics, Department of Vascular Surgery, University of Maryland, Baltimore, MD, USA","Center for Vascular Diagnostics, Department of Vascular Surgery, University of Maryland, Baltimore, 21201 USA"],"affiliations":[{"raw_affiliation_string":"Center for Vascular Diagnostics, Department of Vascular Surgery, University of Maryland, Baltimore, MD, USA","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"Center for Vascular Diagnostics, Department of Vascular Surgery, University of Maryland, Baltimore, 21201 USA","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075067189","display_name":"Siddhartha Sikdar","orcid":"https://orcid.org/0000-0002-6426-2320"},"institutions":[{"id":"https://openalex.org/I162714631","display_name":"George Mason University","ror":"https://ror.org/02jqj7156","country_code":"US","type":"education","lineage":["https://openalex.org/I162714631"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Sikdar","raw_affiliation_strings":["Electrical and Computer Engineering Department and Bioengineering Department, George Mason University, Fairfax, VA, USA","Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030 USA"],"affiliations":[{"raw_affiliation_string":"Electrical and Computer Engineering Department and Bioengineering Department, George Mason University, Fairfax, VA, USA","institution_ids":["https://openalex.org/I162714631"]},{"raw_affiliation_string":"Electrical and Computer Engineering Department, and Bioengineering Department, George Mason University, Fairfax, VA 22030 USA","institution_ids":["https://openalex.org/I162714631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5052856350"],"corresponding_institution_ids":["https://openalex.org/I162714631"],"apc_list":null,"apc_paid":null,"fwci":0.7325,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.75758999,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"148","issue":null,"first_page":"5618","last_page":"5621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stenosis","display_name":"Stenosis","score":0.7538381218910217},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7477314472198486},{"id":"https://openalex.org/keywords/transcranial-doppler","display_name":"Transcranial Doppler","score":0.7388214468955994},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.7313838005065918},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6601599454879761},{"id":"https://openalex.org/keywords/asymptomatic","display_name":"Asymptomatic","score":0.6386218070983887},{"id":"https://openalex.org/keywords/hemodynamics","display_name":"Hemodynamics","score":0.615886390209198},{"id":"https://openalex.org/keywords/carotid-endarterectomy","display_name":"Carotid endarterectomy","score":0.530179500579834},{"id":"https://openalex.org/keywords/circle-of-willis","display_name":"Circle of Willis","score":0.5249742865562439},{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.47655633091926575},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.47327423095703125},{"id":"https://openalex.org/keywords/collateral-circulation","display_name":"Collateral circulation","score":0.4419528841972351},{"id":"https://openalex.org/keywords/collateralization","display_name":"Collateralization","score":0.4236138164997101}],"concepts":[{"id":"https://openalex.org/C2780007028","wikidata":"https://www.wikidata.org/wiki/Q2343082","display_name":"Stenosis","level":2,"score":0.7538381218910217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7477314472198486},{"id":"https://openalex.org/C191616109","wikidata":"https://www.wikidata.org/wiki/Q3512319","display_name":"Transcranial Doppler","level":2,"score":0.7388214468955994},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7313838005065918},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6601599454879761},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.6386218070983887},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.615886390209198},{"id":"https://openalex.org/C2781068581","wikidata":"https://www.wikidata.org/wiki/Q5045544","display_name":"Carotid endarterectomy","level":3,"score":0.530179500579834},{"id":"https://openalex.org/C2780944724","wikidata":"https://www.wikidata.org/wiki/Q487595","display_name":"Circle of Willis","level":2,"score":0.5249742865562439},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.47655633091926575},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.47327423095703125},{"id":"https://openalex.org/C2776599846","wikidata":"https://www.wikidata.org/wiki/Q5145979","display_name":"Collateral circulation","level":2,"score":0.4419528841972351},{"id":"https://openalex.org/C2781223538","wikidata":"https://www.wikidata.org/wiki/Q4227941","display_name":"Collateralization","level":3,"score":0.4236138164997101},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2777910564","wikidata":"https://www.wikidata.org/wiki/Q694563","display_name":"Collateral","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002560","descriptor_name":"Cerebrovascular Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D016893","descriptor_name":"Carotid Stenosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018608","descriptor_name":"Ultrasonography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347268","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347268","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23367203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8399999737739563}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320333868","display_name":"Clinical Science Research and Development","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1969228703","https://openalex.org/W1979388461","https://openalex.org/W2028896052","https://openalex.org/W2029209421","https://openalex.org/W2035772449","https://openalex.org/W2083381805","https://openalex.org/W2112360098","https://openalex.org/W2133910031","https://openalex.org/W2468590728","https://openalex.org/W4240900378"],"related_works":["https://openalex.org/W1508793606","https://openalex.org/W2586110817","https://openalex.org/W2402127527","https://openalex.org/W2802917463","https://openalex.org/W4212855351","https://openalex.org/W2148761940","https://openalex.org/W2798973074","https://openalex.org/W4250650536","https://openalex.org/W2388061226","https://openalex.org/W2391827294"],"abstract_inverted_index":{"Stroke":[0],"is":[1],"the":[2,9,14,30,43,51,54,63,79,89,100,103,114,134,148,156,165,235,242,252],"second":[3],"leading":[4],"cause":[5,85],"of":[6,13,17,21,65,81,88,102,130,147,176,237,251],"death":[7],"in":[8,29,61,73,78,110,113,119,133,164,193],"world,":[10],"and":[11,150,160,197,218,247],"one":[12],"major":[15],"causes":[16],"disability.":[18],"Approximately":[19],"30%":[20],"ischemic":[22],"strokes":[23],"are":[24,231],"due":[25],"to":[26,41,105,154,233,248,254],"plaque":[27,55,66,104,246],"rupture":[28],"carotid":[31,93,123,171,245],"arteries.":[32],"The":[33],"most":[34],"popular":[35],"diagnostic":[36],"method":[37],"uses":[38],"Doppler":[39,139],"ultrasound":[40],"find":[42],"percent":[44],"stenosis.":[45,125,172],"However,":[46],"other":[47],"factors,":[48],"such":[49,208],"as":[50,209],"hemodynamics":[52,243],"around":[53,92,244],"may":[56,98],"play":[57],"a":[58,142,187,219],"larger":[59],"role":[60,236],"identifying":[62],"risk":[64],"rupture.":[67,106],"It":[68],"has":[69],"been":[70],"shown":[71],"previously":[72],"simulations":[74],"that":[75],"non-collateral":[76],"flow":[77,111,162],"circle":[80],"Willis":[82],"(COW)":[83],"could":[84],"an":[86],"increase":[87,99],"intraluminal":[90],"velocity":[91,131,195,221],"plaque.":[94],"This":[95],"added":[96],"strain":[97],"vulnerability":[101],"We":[107,126],"investigated":[108],"asymmetries":[109],"waveforms":[112,132,181],"middle":[115],"cerebral":[116],"artery":[117,124],"(MCA)":[118],"asymptomatic":[120,170],"patients":[121,168,178,214],"with":[122,141,169,183,190,223],"compared":[127],"clinical":[128],"results":[129],"MCA,":[135],"acquired":[136],"using":[137],"transcranial":[138],"(TCD),":[140],"simple":[143],"linear":[144],"simulation":[145],"model":[146],"intra-":[149],"extracranial":[151],"arterial":[152],"network":[153],"investigate":[155],"relationship":[157],"between":[158],"contralateral":[159],"ipsilateral":[161],"profiles":[163],"MCA":[166],"for":[167,186,212,226],"In":[173,200],"17":[174],"out":[175],"23":[177],"we":[179],"found":[180],"consistent":[182],"those":[184],"predicted":[185],"collateralized":[188],"COW,":[189],"minimal":[191],"differences":[192],"delay,":[194],"magnitude":[196],"resistivity":[198],"index.":[199],"6":[201],"cases,":[202],"some":[203],"unexpected":[204],"findings":[205],"were":[206],"noted,":[207],"large":[210,220],"delays":[211],"2":[213],"\u2264":[215],"50%":[216],"stenosis,":[217],"difference":[222],"low":[224],"delay":[225],"4":[227],"patients.":[228],"More":[229],"studies":[230],"needed":[232],"elucidate":[234],"incomplete":[238],"intracranial":[239],"collateralization":[240],"on":[241],"use":[249],"imaging":[250],"COW":[253],"corroborate":[255],"our":[256],"results.":[257]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
