{"id":"https://openalex.org/W2010954353","doi":"https://doi.org/10.1109/embc.2012.6347157","title":"Spatio-temporal inter-ictal activity recorded from human epileptic hippocampal slices","display_name":"Spatio-temporal inter-ictal activity recorded from human epileptic hippocampal slices","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2010954353","doi":"https://doi.org/10.1109/embc.2012.6347157","mag":"2010954353","pmid":"https://pubmed.ncbi.nlm.nih.gov/23367092"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347157","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089991463","display_name":"Min-Chi Hsiao","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min-Chi Hsiao","raw_affiliation_strings":["Department of Biomedical Engineering at University of Southern California USC, Los Angeles, CA 90089, USA. mhsiao@usc.edu","Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering at University of Southern California USC, Los Angeles, CA 90089, USA. mhsiao@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027662718","display_name":"Pen-Ning Yu","orcid":"https://orcid.org/0000-0003-0542-7356"},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pen-Ning Yu","raw_affiliation_strings":["Department of Biomedical Engineering, USC, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1342924430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070732235","display_name":"Dong Song","orcid":"https://orcid.org/0000-0002-6179-1120"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dong Song","raw_affiliation_strings":["Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Center for Neural Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038583687","display_name":"C. Y. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I1342924430","display_name":"LAC+USC Medical Center","ror":"https://ror.org/04xzj3x20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I1342924430"]},{"id":"https://openalex.org/I2800154431","display_name":"Keck Hospital of USC","ror":"https://ror.org/01rq8ck58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431"]},{"id":"https://openalex.org/I2802549562","display_name":"Rancho Los Amigos National Rehabilitation Center","ror":"https://ror.org/03t3q6164","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I2802549562"]},{"id":"https://openalex.org/I4210157890","display_name":"Neurological Surgery","ror":"https://ror.org/04r0gp612","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210157890"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Y. Liu","raw_affiliation_strings":["Department of Neurological Surgery, Adult Comprehensive Epilepsy Program at USC, Keck Hospital of USC, LAC USC Medical Center, Los Angeles, CA, USA","Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurological Surgery, Adult Comprehensive Epilepsy Program at USC, Keck Hospital of USC, LAC USC Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I2800154431","https://openalex.org/I1342924430","https://openalex.org/I4210157890"]},{"raw_affiliation_string":"Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA","institution_ids":["https://openalex.org/I2802549562"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112853584","display_name":"Christi Heck","orcid":null},"institutions":[{"id":"https://openalex.org/I2800154431","display_name":"Keck Hospital of USC","ror":"https://ror.org/01rq8ck58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. N. Heck","raw_affiliation_strings":["Department of Neurology, Adult Comprehensive Epilepsy Program, Keck Hospital of USC, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Adult Comprehensive Epilepsy Program, Keck Hospital of USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I2800154431"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112386761","display_name":"David Millett","orcid":null},"institutions":[{"id":"https://openalex.org/I2800154431","display_name":"Keck Hospital of USC","ror":"https://ror.org/01rq8ck58","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800154431"]},{"id":"https://openalex.org/I2802549562","display_name":"Rancho Los Amigos National Rehabilitation Center","ror":"https://ror.org/03t3q6164","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1328359107","https://openalex.org/I2802549562"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Millett","raw_affiliation_strings":["Department of Neurology, Keck Hospital of USC, Los Angeles, CA, USA","Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Keck Hospital of USC, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I2800154431"]},{"raw_affiliation_string":"Rancho Los Amigos National Rehabilitation Center, Downey, CA, USA","institution_ids":["https://openalex.org/I2802549562"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111911478","display_name":"Theodore W. Berger","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. W. Berger","raw_affiliation_strings":["Department of Biomedical Engineering, Program in Neuroscience and Center for Neural Engineering, USC, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Program in Neuroscience and Center for Neural Engineering, USC, Los Angeles, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":null,"first_page":"5166","last_page":"5169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subiculum","display_name":"Subiculum","score":0.8965052366256714},{"id":"https://openalex.org/keywords/ictal","display_name":"Ictal","score":0.891109049320221},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.7917050123214722},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.778091549873352},{"id":"https://openalex.org/keywords/temporal-lobe","display_name":"Temporal lobe","score":0.7322883009910583},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6719481348991394},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.5793327689170837},{"id":"https://openalex.org/keywords/mesial-temporal-lobe-epilepsy","display_name":"Mesial temporal lobe epilepsy","score":0.5375224351882935},{"id":"https://openalex.org/keywords/lamotrigine","display_name":"Lamotrigine","score":0.47570547461509705},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4648045301437378},{"id":"https://openalex.org/keywords/dentate-gyrus","display_name":"Dentate gyrus","score":0.43993037939071655},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3050665855407715}],"concepts":[{"id":"https://openalex.org/C2778499278","wikidata":"https://www.wikidata.org/wiki/Q1499420","display_name":"Subiculum","level":4,"score":0.8965052366256714},{"id":"https://openalex.org/C17755696","wikidata":"https://www.wikidata.org/wiki/Q16564780","display_name":"Ictal","level":3,"score":0.891109049320221},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.7917050123214722},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.778091549873352},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.7322883009910583},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6719481348991394},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5793327689170837},{"id":"https://openalex.org/C2994116697","wikidata":"https://www.wikidata.org/wiki/Q616667","display_name":"Mesial temporal lobe epilepsy","level":4,"score":0.5375224351882935},{"id":"https://openalex.org/C2778802184","wikidata":"https://www.wikidata.org/wiki/Q410346","display_name":"Lamotrigine","level":3,"score":0.47570547461509705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4648045301437378},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.43993037939071655},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3050665855407715}],"mesh":[{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004867","descriptor_name":"Equipment Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008839","descriptor_name":"Microelectrodes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D009924","descriptor_name":"Organ Culture Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019544","descriptor_name":"Equipment Failure Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347157","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347157","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23367092","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23367092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8100000023841858}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1611572442","https://openalex.org/W1974809694","https://openalex.org/W2004115145","https://openalex.org/W2028756092","https://openalex.org/W2066333735","https://openalex.org/W2069586118","https://openalex.org/W2084148692","https://openalex.org/W2095025631","https://openalex.org/W2102869980","https://openalex.org/W2114499550","https://openalex.org/W2115720575","https://openalex.org/W2127019545","https://openalex.org/W2135629133","https://openalex.org/W2145617691","https://openalex.org/W2149509587","https://openalex.org/W2155388215","https://openalex.org/W2156463085","https://openalex.org/W2167139422","https://openalex.org/W2415778488","https://openalex.org/W2479151136","https://openalex.org/W6683193954"],"related_works":["https://openalex.org/W3022859466","https://openalex.org/W2026350127","https://openalex.org/W3110479941","https://openalex.org/W2015878647","https://openalex.org/W2790553598","https://openalex.org/W2767316930","https://openalex.org/W1978742383","https://openalex.org/W2040377233","https://openalex.org/W2365242551","https://openalex.org/W3031020408"],"abstract_inverted_index":{"Epilepsy":[0],"is":[1,48,61],"a":[2,9,49,92],"medical":[3,31],"syndrome":[4],"that":[5],"produces":[6],"seizures":[7],"affecting":[8],"variety":[10],"of":[11,19,24,37,40,58],"mental":[12],"and":[13,22,130,156],"physical":[14],"functions.":[15],"The":[16,117],"actual":[17],"mechanisms":[18],"the":[20,25,35,59,64,134],"onset":[21],"termination":[23],"seizure":[26,147],"are":[27],"still":[28],"unclear.":[29],"While":[30],"therapies":[32],"can":[33,100,121],"suppress":[34],"symptoms":[36],"seizures,":[38],"30%":[39],"patients":[41,83],"do":[42],"not":[43],"respond":[44],"well.":[45],"Temporal":[46],"lobectomy":[47],"common":[50],"surgical":[51],"treatment":[52],"for":[53],"medically":[54],"refractory":[55],"epilepsy.":[56,90],"Part":[57],"hippocampus":[60],"removed":[62],"from":[63,82,85],"patient.":[65],"In":[66],"this":[67,139],"study,":[68],"we":[69],"have":[70],"developed":[71],"an":[72],"in":[73,77,104,124,138],"vitro":[74],"epileptic":[75],"model":[76,136],"human":[78],"hippocampal":[79],"slices":[80],"resected":[81],"suffering":[84],"intractable":[86],"mesial":[87],"temporal":[88],"lobe":[89],"Using":[91],"planar":[93],"multielectrode":[94],"array":[95],"system,":[96],"spatio-temporal":[97],"inter-ictal":[98,119],"activity":[99,120],"be":[101,122],"consistently":[102],"recorded":[103,123],"high-potassium":[105],"(8":[106],"mM),":[107],"low-magnesium":[108],"(0.25":[109],"mM)":[110],"aCSF":[111],"with":[112],"additional":[113],"100":[114],"\u00b5M":[115],"4-aminopyridine.":[116],"induced":[118],"different":[125],"regions":[126],"including":[127],"dentate,":[128],"CA1":[129],"Subiculum.":[131],"We":[132],"hope":[133],"experimental":[135],"built":[137],"study":[140],"will":[141],"help":[142],"us":[143],"understand":[144],"more":[145],"about":[146],"generation,":[148],"as":[149,151],"well":[150],"providing":[152],"insights":[153],"into":[154],"prevention":[155],"novel":[157],"therapeutics.":[158]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2025-10-10T00:00:00"}
