{"id":"https://openalex.org/W2024600615","doi":"https://doi.org/10.1109/embc.2012.6347011","title":"Effect of hypothermia on the thalamocortical function in the rat model","display_name":"Effect of hypothermia on the thalamocortical function in the rat model","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2024600615","doi":"https://doi.org/10.1109/embc.2012.6347011","mag":"2024600615","pmid":"https://pubmed.ncbi.nlm.nih.gov/23366972"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6347011","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347011","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023767636","display_name":"A. Maybhate","orcid":"https://orcid.org/0000-0002-7564-8536"},"institutions":[{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Maybhate","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA. anil@jhmi.edu","Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA. anil@jhmi.edu","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100420560","display_name":"Cheng Chen","orcid":"https://orcid.org/0000-0002-7323-1104"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Chen","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088964967","display_name":"Nitish V. Thakor","orcid":"https://orcid.org/0000-0002-9981-9395"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. V. Thakor","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100612505","display_name":"Xiaofeng Jia","orcid":"https://orcid.org/0000-0003-1445-8525"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaofeng Jia","raw_affiliation_strings":["Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Avenue, Traylor Building, Room 710-C, Baltimore, MD 21205, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5023767636"],"corresponding_institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"],"apc_list":null,"apc_paid":null,"fwci":0.1849,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.5788696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"56","issue":null,"first_page":"4680","last_page":"4683"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10645","display_name":"Cardiac Arrest and Resuscitation","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.8244755268096924},{"id":"https://openalex.org/keywords/hypothermia","display_name":"Hypothermia","score":0.7970267534255981},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6650911569595337},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"Neuroprotection","score":0.6052069664001465},{"id":"https://openalex.org/keywords/somatosensory-system","display_name":"Somatosensory system","score":0.5577876567840576},{"id":"https://openalex.org/keywords/local-field-potential","display_name":"Local field potential","score":0.4956859350204468},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4671684503555298},{"id":"https://openalex.org/keywords/rat-model","display_name":"Rat model","score":0.42484280467033386},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.4116052985191345},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.3564070463180542},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.33496028184890747},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17831459641456604}],"concepts":[{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.8244755268096924},{"id":"https://openalex.org/C2777390192","wikidata":"https://www.wikidata.org/wiki/Q1036696","display_name":"Hypothermia","level":2,"score":0.7970267534255981},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6650911569595337},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6052069664001465},{"id":"https://openalex.org/C172497186","wikidata":"https://www.wikidata.org/wiki/Q328835","display_name":"Somatosensory system","level":2,"score":0.5577876567840576},{"id":"https://openalex.org/C117838684","wikidata":"https://www.wikidata.org/wiki/Q533483","display_name":"Local field potential","level":2,"score":0.4956859350204468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4671684503555298},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.42484280467033386},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4116052985191345},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3564070463180542},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.33496028184890747},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17831459641456604}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007035","descriptor_name":"Hypothermia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007035","descriptor_name":"Hypothermia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007035","descriptor_name":"Hypothermia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013003","descriptor_name":"Somatosensory Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013787","descriptor_name":"Thalamic Nuclei","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6347011","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6347011","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23366972","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23366972","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1968398093","https://openalex.org/W1973474414","https://openalex.org/W1979916433","https://openalex.org/W1985230697","https://openalex.org/W1988029624","https://openalex.org/W1992740876","https://openalex.org/W1996236451","https://openalex.org/W2026380971","https://openalex.org/W2041180516","https://openalex.org/W2052128673","https://openalex.org/W2055736398","https://openalex.org/W2058056440","https://openalex.org/W2062642814","https://openalex.org/W2084989826","https://openalex.org/W2098699774","https://openalex.org/W2112596836","https://openalex.org/W2113762408","https://openalex.org/W2120561852","https://openalex.org/W2131729872","https://openalex.org/W2137303544","https://openalex.org/W2155399089","https://openalex.org/W2161512811","https://openalex.org/W2178225550","https://openalex.org/W2313797090","https://openalex.org/W6676879379"],"related_works":["https://openalex.org/W1480298651","https://openalex.org/W2293954084","https://openalex.org/W1604036919","https://openalex.org/W2009016507","https://openalex.org/W2039352766","https://openalex.org/W1968014587","https://openalex.org/W2011274314","https://openalex.org/W2943583691","https://openalex.org/W1999326214","https://openalex.org/W2338971691"],"abstract_inverted_index":{"Neuroprotective":[0],"effects":[1],"of":[2,10,40,47,65,123,147],"hypothermia":[3],"are":[4,27],"well":[5,19],"documented":[6],"in":[7,15,102,129],"many":[8],"injuries":[9],"the":[11,24,38,44,48,56,63,70,85,90,106,120,124],"central":[12],"nervous":[13],"system":[14],"animal":[16],"models":[17],"as":[18,20],"clinical":[21],"studies.":[22],"However,":[23],"underlying":[25],"mechanisms":[26],"not":[28],"fully":[29],"understood.":[30],"An":[31],"important":[32,143],"yet":[33],"unexplored":[34],"background":[35],"issue":[36],"is":[37],"effect":[39,64],"hypothermic":[41,97],"cooling":[42,68,133],"on":[43,69],"regional":[45],"functionality":[46],"healthy":[49,103],"CNS.":[50],"In":[51],"a":[52],"pilot":[53],"study":[54],"with":[55,111,131,136],"rat":[57],"model,":[58],"we":[59],"seek":[60],"to":[61],"characterize":[62],"moderate":[66],"bodily":[67,132],"thalamo-cortical":[71,107],"(T-C)":[72],"function.":[73],"Multiunit":[74],"activity":[75,126],"(MUA)":[76],"and":[77,89,98,105,134],"local":[78],"field":[79],"potentials":[80],"(LFPs)":[81],"were":[82],"recorded":[83],"from":[84],"thalamus":[86],"(VPL":[87],"nucleus)":[88],"somatosensory":[91],"cortex":[92],"(S1)":[93],"for":[94],"normothermic,":[95],"mild":[96,99,137],"hyperthermic":[100],"conditions":[101],"rats":[104],"dynamics":[108],"was":[109],"characterized":[110],"Granger":[112],"Causal":[113],"Interaction":[114],"(GCI).":[115],"The":[116],"GCI":[117],"indicated":[118],"that":[119],"thalamic":[121],"driving":[122],"cortical":[125],"significantly":[127],"increases":[128],"strength":[130],"weakens":[135],"heating.":[138],"These":[139],"results":[140],"could":[141],"have":[142],"implications":[144],"towards":[145],"understanding":[146],"hypothermia.":[148]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}