{"id":"https://openalex.org/W2001605839","doi":"https://doi.org/10.1109/embc.2012.6346625","title":"Autonomic control mechanism of maximal lower body negative pressure application","display_name":"Autonomic control mechanism of maximal lower body negative pressure application","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2001605839","doi":"https://doi.org/10.1109/embc.2012.6346625","mag":"2001605839","pmid":"https://pubmed.ncbi.nlm.nih.gov/23366586"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6346625","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023894020","display_name":"Nandakumar Selvaraj","orcid":null},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]},{"id":"https://openalex.org/I4210129612","display_name":"VitalConnect (United States)","ror":"https://ror.org/0350fs434","country_code":"US","type":"company","lineage":["https://openalex.org/I4210129612"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. Selvaraj","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA. snandaa@gmail.com","Vital Connect Inc., Campbell, CA 95008 USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA 01609, USA. snandaa@gmail.com","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Vital Connect Inc., Campbell, CA 95008 USA","institution_ids":["https://openalex.org/I4210129612"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058798075","display_name":"Kirk H. Shelley","orcid":"https://orcid.org/0000-0002-7344-0897"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. H. Shelley","raw_affiliation_strings":["Department of Anesthesiology, Yale University, New Heaven, CT, USA","Department of Anesthesiology, Yale University, New Haven, CT 06520 USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Anesthesiology, Yale University, New Haven, CT 06520 USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049465222","display_name":"David G. Silverman","orcid":"https://orcid.org/0000-0003-1842-5739"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. G. Silverman","raw_affiliation_strings":["Department of Anesthesiology, Yale University, New Heaven, CT, USA","Department of Anesthesiology, Yale University, New Haven, CT 06520 USA"],"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Yale University, New Heaven, CT, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Anesthesiology, Yale University, New Haven, CT 06520 USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025562404","display_name":"Nina S. Stachenfeld","orcid":"https://orcid.org/0000-0002-6597-5031"},"institutions":[{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Stachenfeld","raw_affiliation_strings":["John B. Pierce Laboratory, New Heaven, CT, USA","John B. Pierce Laboratory, New Haven, CT 06519 USA"],"affiliations":[{"raw_affiliation_string":"John B. Pierce Laboratory, New Heaven, CT, USA","institution_ids":["https://openalex.org/I4210098204"]},{"raw_affiliation_string":"John B. Pierce Laboratory, New Haven, CT 06519 USA","institution_ids":["https://openalex.org/I4210098204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032573836","display_name":"Ki H. Chon","orcid":"https://orcid.org/0000-0002-4422-4837"},"institutions":[{"id":"https://openalex.org/I107077323","display_name":"Worcester Polytechnic Institute","ror":"https://ror.org/05ejpqr48","country_code":"US","type":"education","lineage":["https://openalex.org/I107077323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. H. Chon","raw_affiliation_strings":["Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA","institution_ids":["https://openalex.org/I107077323"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA","institution_ids":["https://openalex.org/I107077323"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023894020"],"corresponding_institution_ids":["https://openalex.org/I107077323","https://openalex.org/I4210129612"],"apc_list":null,"apc_paid":null,"fwci":0.1863,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.58182657,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2012","issue":null,"first_page":"3120","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11196","display_name":"Non-Invasive Vital Sign Monitoring","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/baroreflex","display_name":"Baroreflex","score":0.9209976196289062},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"Heart rate variability","score":0.7722045183181763},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"Blood pressure","score":0.7021346688270569},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6267191171646118},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.6107244491577148},{"id":"https://openalex.org/keywords/heart-rate","display_name":"Heart rate","score":0.5762152671813965},{"id":"https://openalex.org/keywords/reflex","display_name":"Reflex","score":0.5726425051689148},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5122343897819519},{"id":"https://openalex.org/keywords/lower-body","display_name":"Lower body","score":0.474540114402771},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"Autonomic nervous system","score":0.44925200939178467},{"id":"https://openalex.org/keywords/anesthesia","display_name":"Anesthesia","score":0.32994282245635986}],"concepts":[{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.9209976196289062},{"id":"https://openalex.org/C71635504","wikidata":"https://www.wikidata.org/wiki/Q933954","display_name":"Heart rate variability","level":4,"score":0.7722045183181763},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7021346688270569},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6267191171646118},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6107244491577148},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5762152671813965},{"id":"https://openalex.org/C83974742","wikidata":"https://www.wikidata.org/wiki/Q179405","display_name":"Reflex","level":2,"score":0.5726425051689148},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5122343897819519},{"id":"https://openalex.org/C3018708532","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Lower body","level":2,"score":0.474540114402771},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.44925200939178467},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.32994282245635986}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008150","descriptor_name":"Lower Body Negative Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6346625","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346625","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23366586","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23366586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1553375296","https://openalex.org/W1979726128","https://openalex.org/W1990827987","https://openalex.org/W1994558230","https://openalex.org/W2004028584","https://openalex.org/W2021791192","https://openalex.org/W2032445864","https://openalex.org/W2043737500","https://openalex.org/W2049571914","https://openalex.org/W2062618262","https://openalex.org/W2086155609","https://openalex.org/W2090626911","https://openalex.org/W2091732895","https://openalex.org/W2137322371","https://openalex.org/W2151499534","https://openalex.org/W2183374069","https://openalex.org/W2189201168","https://openalex.org/W2225916174","https://openalex.org/W4246019005"],"related_works":["https://openalex.org/W2273745536","https://openalex.org/W4387253560","https://openalex.org/W1548647706","https://openalex.org/W2501692008","https://openalex.org/W4386224683","https://openalex.org/W4214500667","https://openalex.org/W4360974335","https://openalex.org/W3120791867","https://openalex.org/W1847525600","https://openalex.org/W4385546015"],"abstract_inverted_index":{"Autonomic":[0],"control":[1],"mechanisms":[2],"during":[3,19,126],"progressive":[4],"hemorrhage":[5,31,162],"in":[6,32,108,141],"humans":[7],"remain":[8],"complex":[9],"and":[10,44,50,63,78,94,102,117,147,151],"unclear.":[11],"The":[12,70],"present":[13],"study":[14],"investigates":[15],"the":[16,76,131,143],"autonomic":[17],"reflexes":[18],"maximal":[20,71,127,157],"application":[21,73,155],"of":[22,39,55,92,120,133,156,170],"lower":[23],"body":[24],"negative":[25],"pressure":[26,47,113],"(LBNP)":[27],"that":[28,159],"mimics":[29],"severe":[30,161],"conscious":[33],"human":[34],"subjects":[35],"(n=10)":[36],"using":[37,122],"analyses":[38],"heart":[40,109],"rate":[41],"variability":[42,48],"(HRV)":[43],"systolic":[45,77],"blood":[46,112],"(BPV)":[49],"baroreflex":[51,171],"sensitivity.":[52],"Spectral":[53],"analysis":[54],"HRV":[56,121],"included":[57],"linear":[58],"power":[59,91],"spectral":[60],"density":[61],"(PSD),":[62],"nonlinear":[64],"principal":[65],"dynamic":[66],"modes":[67],"(PDM)":[68],"methods.":[69],"LBNP":[72,128,158],"decreased":[74],"(P<0.01)":[75],"pulse":[79],"pressures":[80],"(PP),":[81],"root":[82],"mean":[83],"square":[84],"successive":[85],"differences,":[86],"normalized":[87],"high":[88],"frequency":[89,100],"(HF)":[90],"HRV,":[93],"transfer":[95],"function":[96],"gains":[97],"at":[98],"low":[99],"(LF)":[101],"HF":[103],"bands.":[104],"Meanwhile,":[105],"increases":[106],"(P<0.05)":[107],"rate,":[110],"diastolic":[111],"(DBP),":[114],"LFHRV,":[115],"LF/HFHRV,":[116],"sympathetic":[118,174],"activity":[119],"PDM":[123],"were":[124,139],"observed":[125],"tolerance.":[129],"After":[130],"termination":[132],"LBNP,":[134],"no":[135],"significant":[136],"changes":[137],"(P>0.05)":[138],"found":[140,164],"all":[142],"parameters":[144],"except":[145],"DBP":[146],"PP":[148],"between":[149],"recovery":[150],"baseline":[152],"conditions.":[153],"Rapid":[154],"simulated":[160],"was":[163],"to":[165],"be":[166],"associated":[167],"with":[168],"unloading":[169],"mediated":[172],"increased":[173],"reflex.":[175]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}