{"id":"https://openalex.org/W2138833301","doi":"https://doi.org/10.1109/embc.2012.6346224","title":"A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue","display_name":"A fresh look at the validity of the diffusion approximation for modeling fluorescence spectroscopy in biological tissue","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2138833301","doi":"https://doi.org/10.1109/embc.2012.6346224","mag":"2138833301","pmid":"https://pubmed.ncbi.nlm.nih.gov/23366185"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6346224","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346224","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079547600","display_name":"Chintha C. Handapangoda","orcid":null},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"C. C. Handapangoda","raw_affiliation_strings":["Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia. chinthah@gmail.com","Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia"],"affiliations":[{"raw_affiliation_string":"Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia. chinthah@gmail.com","institution_ids":["https://openalex.org/I149704539"]},{"raw_affiliation_string":"Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia","institution_ids":["https://openalex.org/I149704539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088983596","display_name":"Malin Premaratne","orcid":"https://orcid.org/0000-0002-2419-4431"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"M. Premaratne","raw_affiliation_strings":["Advanced Computing and Simulation Laboratory (A L), Department of Electrical and Computer Systems Engineering, Monash University, Clayton, VIC, Australia","Advanced Computing and Simulation Laboratory (AxL), Department of Electrical and Computer Systems Engineering, Monash University, Clayton, Victoria 3800, Australia"],"affiliations":[{"raw_affiliation_string":"Advanced Computing and Simulation Laboratory (A L), Department of Electrical and Computer Systems Engineering, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Advanced Computing and Simulation Laboratory (AxL), Department of Electrical and Computer Systems Engineering, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015293969","display_name":"Saeid Nahavandi","orcid":"https://orcid.org/0000-0002-0360-5270"},"institutions":[{"id":"https://openalex.org/I149704539","display_name":"Deakin University","ror":"https://ror.org/02czsnj07","country_code":"AU","type":"education","lineage":["https://openalex.org/I149704539"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Nahavandi","raw_affiliation_strings":["Centre for Intelligent Systems Research, Deakin University, Geelong, VIC, Australia","Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia"],"affiliations":[{"raw_affiliation_string":"Centre for Intelligent Systems Research, Deakin University, Geelong, VIC, Australia","institution_ids":["https://openalex.org/I149704539"]},{"raw_affiliation_string":"Centre for Intelligent Systems Research, Deakin University, Geelong, Victoria 3217, Australia","institution_ids":["https://openalex.org/I149704539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5079547600"],"corresponding_institution_ids":["https://openalex.org/I149704539"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18671532,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":null,"first_page":"1494","last_page":"1497"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.7819423079490662},{"id":"https://openalex.org/keywords/spectroscopy","display_name":"Spectroscopy","score":0.7041317224502563},{"id":"https://openalex.org/keywords/fluorescence-spectroscopy","display_name":"Fluorescence spectroscopy","score":0.6401667594909668},{"id":"https://openalex.org/keywords/fluorescence-correlation-spectroscopy","display_name":"Fluorescence correlation spectroscopy","score":0.5860530138015747},{"id":"https://openalex.org/keywords/biological-tissue","display_name":"Biological tissue","score":0.5687330365180969},{"id":"https://openalex.org/keywords/fluorescence-cross-correlation-spectroscopy","display_name":"Fluorescence cross-correlation spectroscopy","score":0.5340019464492798},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5320858359336853},{"id":"https://openalex.org/keywords/photon","display_name":"Photon","score":0.5235342979431152},{"id":"https://openalex.org/keywords/time-resolved-spectroscopy","display_name":"Time-resolved spectroscopy","score":0.4624161720275879},{"id":"https://openalex.org/keywords/photon-diffusion","display_name":"Photon diffusion","score":0.4465368986129761},{"id":"https://openalex.org/keywords/excitation","display_name":"Excitation","score":0.4178239703178406},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39503413438796997},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3553706407546997},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3504628539085388},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.3364734947681427},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.3065098524093628},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2957924008369446},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.07942712306976318}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.7819423079490662},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.7041317224502563},{"id":"https://openalex.org/C158711907","wikidata":"https://www.wikidata.org/wiki/Q1768467","display_name":"Fluorescence spectroscopy","level":3,"score":0.6401667594909668},{"id":"https://openalex.org/C144618238","wikidata":"https://www.wikidata.org/wiki/Q902601","display_name":"Fluorescence correlation spectroscopy","level":3,"score":0.5860530138015747},{"id":"https://openalex.org/C2983453321","wikidata":"https://www.wikidata.org/wiki/Q40397","display_name":"Biological tissue","level":2,"score":0.5687330365180969},{"id":"https://openalex.org/C36038061","wikidata":"https://www.wikidata.org/wiki/Q8564081","display_name":"Fluorescence cross-correlation spectroscopy","level":4,"score":0.5340019464492798},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5320858359336853},{"id":"https://openalex.org/C159317903","wikidata":"https://www.wikidata.org/wiki/Q3198","display_name":"Photon","level":2,"score":0.5235342979431152},{"id":"https://openalex.org/C133279788","wikidata":"https://www.wikidata.org/wiki/Q7804835","display_name":"Time-resolved spectroscopy","level":3,"score":0.4624161720275879},{"id":"https://openalex.org/C47019982","wikidata":"https://www.wikidata.org/wiki/Q305032","display_name":"Photon diffusion","level":3,"score":0.4465368986129761},{"id":"https://openalex.org/C83581075","wikidata":"https://www.wikidata.org/wiki/Q1361503","display_name":"Excitation","level":2,"score":0.4178239703178406},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39503413438796997},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3553706407546997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3504628539085388},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.3364734947681427},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.3065098524093628},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2957924008369446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07942712306976318},{"id":"https://openalex.org/C2982854487","wikidata":"https://www.wikidata.org/wiki/Q9128","display_name":"Light source","level":2,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013050","descriptor_name":"Spectrometry, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019265","descriptor_name":"Spectroscopy, Near-Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1109/embc.2012.6346224","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6346224","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23366185","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23366185","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null},{"id":"pmh:oai:dro.deakin.edu.au:DU:30050977","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306402457","display_name":"Deakin Research Online (Deakin University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149704539","host_organization_name":"Deakin University","host_organization_lineage":["https://openalex.org/I149704539"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W578387667","https://openalex.org/W1738557335","https://openalex.org/W1971397175","https://openalex.org/W1982162561","https://openalex.org/W2020444919","https://openalex.org/W2034028838","https://openalex.org/W2039832787","https://openalex.org/W2043093884","https://openalex.org/W2056177869","https://openalex.org/W2057798149","https://openalex.org/W2122287305","https://openalex.org/W2136279246","https://openalex.org/W2139701685","https://openalex.org/W2156059855"],"related_works":["https://openalex.org/W2077751539","https://openalex.org/W4799174","https://openalex.org/W1974622548","https://openalex.org/W2404211371","https://openalex.org/W2093068017","https://openalex.org/W2042464131","https://openalex.org/W2468630222","https://openalex.org/W1989008401","https://openalex.org/W2413144020","https://openalex.org/W2085436366"],"abstract_inverted_index":{"Fluorescence":[0],"has":[1],"become":[2],"a":[3],"widely":[4,51],"used":[5,17,52],"technique":[6],"for":[7,18,69],"applications":[8],"in":[9,23,55,81,85],"noninvasive":[10],"diagnostic":[11],"tissue":[12,25,87],"spectroscopy.":[13],"The":[14,75],"standard":[15],"model":[16],"characterizing":[19],"fluorescence":[20,56,83],"photon":[21,43],"transport":[22,71],"biological":[24,86],"is":[26,88],"based":[27],"on":[28],"the":[29,33,36,50,70],"diffusion":[30,53],"approximation.":[31],"On":[32],"premise":[34],"that":[35,60],"total":[37],"energy":[38],"of":[39,72,77],"excitation":[40],"and":[41,58],"fluorescent":[42,73],"flows":[44],"must":[45,62],"be":[46,63],"conserved,":[47],"we":[48],"derive":[49],"equations":[54],"spectroscopy":[57,84],"show":[59],"there":[61],"an":[64],"additional":[65,79],"term":[66,80],"to":[67],"account":[68],"photons.":[74],"significance":[76],"this":[78],"modeling":[82],"assessed.":[89]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}
