{"id":"https://openalex.org/W2084454304","doi":"https://doi.org/10.1109/embc.2012.6345949","title":"Effect of gadobutrol on VX2 magnetic resonance diffusion-weighted imaging","display_name":"Effect of gadobutrol on VX2 magnetic resonance diffusion-weighted imaging","publication_year":2012,"publication_date":"2012-08-01","ids":{"openalex":"https://openalex.org/W2084454304","doi":"https://doi.org/10.1109/embc.2012.6345949","mag":"2084454304","pmid":"https://pubmed.ncbi.nlm.nih.gov/23365910"},"language":"en","primary_location":{"id":"doi:10.1109/embc.2012.6345949","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6345949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016837919","display_name":"P.-C Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"P.-C Chen","raw_affiliation_strings":["Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC. pcchen@isu.kmu.edu.tw","Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC. pcchen@isu.kmu.edu.tw","institution_ids":["https://openalex.org/I98298690"]},{"raw_affiliation_string":"Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035117112","display_name":"Jo\u2010Chi Jao","orcid":"https://orcid.org/0000-0001-7360-9376"},"institutions":[{"id":"https://openalex.org/I152743029","display_name":"Kaohsiung Medical University","ror":"https://ror.org/03gk81f96","country_code":"TW","type":"education","lineage":["https://openalex.org/I152743029"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"J.-C Jao","raw_affiliation_strings":["Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan","Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, 807, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I152743029"]},{"raw_affiliation_string":"Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, 807, Taiwan, ROC","institution_ids":["https://openalex.org/I152743029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047966322","display_name":"Ding-Jie LIN","orcid":null},"institutions":[{"id":"https://openalex.org/I98298690","display_name":"I-Shou University","ror":"https://ror.org/04d7e4m76","country_code":"TW","type":"education","lineage":["https://openalex.org/I98298690"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"D.-J Lin","raw_affiliation_strings":["Department of Biomedical Engineering, I-SHOU University, Kaohsiung, Taiwan","Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, I-SHOU University, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I98298690"]},{"raw_affiliation_string":"Department of Biomedical Engineering, I-SHOU University, Kaohsiung 824, Taiwan, ROC","institution_ids":["https://openalex.org/I98298690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085708470","display_name":"Chu-Yuan Hsiao","orcid":"https://orcid.org/0009-0003-5542-6826"},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C.-C Hsiao","raw_affiliation_strings":["Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","Department of Radiology, Kaohsiung Veterans General Hospital, 813, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210152230"]},{"raw_affiliation_string":"Department of Radiology, Kaohsiung Veterans General Hospital, 813, Taiwan, ROC","institution_ids":["https://openalex.org/I4210152230"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033433664","display_name":"Huay\u2010Ben Pan","orcid":"https://orcid.org/0000-0002-9326-2098"},"institutions":[{"id":"https://openalex.org/I4210152230","display_name":"Kaohsiung Veterans General Hospital","ror":"https://ror.org/04jedda80","country_code":"TW","type":"funder","lineage":["https://openalex.org/I4210152230"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"H.-B Pan","raw_affiliation_strings":["Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","Department of Radiology, Kaohsiung Veterans General Hospital, 813, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan","institution_ids":["https://openalex.org/I4210152230"]},{"raw_affiliation_string":"Department of Radiology, Kaohsiung Veterans General Hospital, 813, Taiwan, ROC","institution_ids":["https://openalex.org/I4210152230"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2564,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64396079,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2012","issue":null,"first_page":"384","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gadobutrol","display_name":"Gadobutrol","score":0.9829387664794922},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.8345018625259399},{"id":"https://openalex.org/keywords/effective-diffusion-coefficient","display_name":"Effective diffusion coefficient","score":0.6797674894332886},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.5805977582931519},{"id":"https://openalex.org/keywords/nuclear-magnetic-resonance","display_name":"Nuclear magnetic resonance","score":0.4916451573371887},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.45306381583213806},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.419704407453537},{"id":"https://openalex.org/keywords/gadolinium","display_name":"Gadolinium","score":0.41622835397720337},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.38505011796951294},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.3059356212615967},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1183600127696991}],"concepts":[{"id":"https://openalex.org/C2776875665","wikidata":"https://www.wikidata.org/wiki/Q2570844","display_name":"Gadobutrol","level":3,"score":0.9829387664794922},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.8345018625259399},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.6797674894332886},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.5805977582931519},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.4916451573371887},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.45306381583213806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.419704407453537},{"id":"https://openalex.org/C557651011","wikidata":"https://www.wikidata.org/wiki/Q1832","display_name":"Gadolinium","level":2,"score":0.41622835397720337},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.38505011796951294},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3059356212615967},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1183600127696991},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1109/embc.2012.6345949","is_oa":false,"landing_page_url":"https://doi.org/10.1109/embc.2012.6345949","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society","raw_type":"proceedings-article"},{"id":"pmid:23365910","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23365910","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1977140291","https://openalex.org/W2007092107","https://openalex.org/W2007684905","https://openalex.org/W2038961815","https://openalex.org/W2084573604","https://openalex.org/W2085236333","https://openalex.org/W2089864641","https://openalex.org/W2148444243","https://openalex.org/W2170655079"],"related_works":["https://openalex.org/W4301391107","https://openalex.org/W4283259974","https://openalex.org/W2803232995","https://openalex.org/W3011727973","https://openalex.org/W2094149890","https://openalex.org/W4297855528","https://openalex.org/W2035316823","https://openalex.org/W2695198348","https://openalex.org/W2945339633","https://openalex.org/W3002091697"],"abstract_inverted_index":{"The":[0,58,76],"aim":[1],"of":[2,10,47,119,140],"this":[3],"study":[4],"was":[5,52,61],"to":[6],"evaluate":[7],"the":[8,15,44,55,85,114,135],"effect":[9],"contrast":[11],"agent":[12],"gadobutrol":[13,103,147],"on":[14,43],"magnetic":[16],"resonance":[17],"diffusion-weighted":[18],"imaging":[19],"(MR":[20],"DWI).":[21],"Gadobutrol":[22],"has":[23,31],"higher":[24,32],"relaxivity":[25],"than":[26,36],"Gd-DTPA":[27,37],"and":[28,89,97,101,116,124,142,145],"it":[29],"also":[30,130],"formulation":[33],"1.0":[34],"M":[35],"0.5":[38],"M.":[39],"VX2":[40],"tumor":[41,96,120,141],"implanted":[42],"left":[45],"thigh":[46],"each":[48],"New":[49],"Zealand":[50],"rabbit":[51],"used":[53],"as":[54],"animal":[56],"model.":[57],"MR":[59,69],"scanning":[60],"performed":[62],"using":[63],"a":[64],"1.5":[65],"T":[66],"clinical":[67],"whole-body":[68],"scanner":[70],"with":[71],"an":[72],"8-channel":[73],"knee":[74],"coil.":[75],"results":[77],"showed":[78],"that":[79],"there":[80,108],"were":[81,109,129],"significant":[82,111,132],"differences":[83,112],"in":[84,113,134],"signal-to-noise":[86],"ratio":[87,137],"(SNR)":[88],"apparent":[90],"diffusion":[91],"coefficient":[92],"(ADC)":[93],"values":[94,118,139],"between":[95],"muscle":[98,122,143],"both":[99],"before":[100,123,144],"after":[102,125,146],"injection":[104],"(0.1":[105],"mmol/kg).":[106],"However,":[107],"no":[110,131],"SNR":[115],"ADC":[117],"or":[121],"gadobutol":[126],"administration.":[127],"There":[128],"difference":[133],"contrast-to-noise":[136],"(CNR)":[138],"injection.":[148]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}