{"id":"https://openalex.org/W2560422232","doi":"https://doi.org/10.1109/ecc.2016.7810556","title":"Biomolecular implementation of nonlinear system theoretic operators","display_name":"Biomolecular implementation of nonlinear system theoretic operators","publication_year":2016,"publication_date":"2016-06-01","ids":{"openalex":"https://openalex.org/W2560422232","doi":"https://doi.org/10.1109/ecc.2016.7810556","mag":"2560422232"},"language":"en","primary_location":{"id":"doi:10.1109/ecc.2016.7810556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ecc.2016.7810556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 European Control Conference (ECC)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pureportal.coventry.ac.uk/en/publications/3d066dab-41eb-435c-8820-7b90c4ee067a","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025432609","display_name":"Mathias Foo","orcid":"https://orcid.org/0000-0003-1400-2659"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mathias Foo","raw_affiliation_strings":["University of Warwick, Coventry, West Midlands, GB"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Warwick, Coventry, West Midlands, GB","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068046998","display_name":"Rucha Sawlekar","orcid":null},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rucha Sawlekar","raw_affiliation_strings":["Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334905","display_name":"Jongmin Kim","orcid":"https://orcid.org/0000-0002-2713-1006"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jongmin Kim","raw_affiliation_strings":["Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077819322","display_name":"Declan G. Bates","orcid":"https://orcid.org/0000-0003-1395-9846"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Declan G. Bates","raw_affiliation_strings":["Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086007559","display_name":"Guy\u2010Bart Stan","orcid":"https://orcid.org/0000-0002-5560-902X"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Guy-Bart Stan","raw_affiliation_strings":["Department of Bioengineering, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009592061","display_name":"Vishwesh Kulkarni","orcid":"https://orcid.org/0000-0002-2285-8652"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vishwesh Kulkarni","raw_affiliation_strings":["Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Warwick Integrative Synthetic Biology (WISB), University of Warwick, Coventry, UK","institution_ids":["https://openalex.org/I39555362"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2631,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.95755322,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"107","issue":null,"first_page":"1824","last_page":"1831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13052","display_name":"Molecular Communication and Nanonetworks","score":0.9944000244140625,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6242993474006653},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.6206718683242798},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.593840479850769},{"id":"https://openalex.org/keywords/maximization","display_name":"Maximization","score":0.5110974907875061},{"id":"https://openalex.org/keywords/chemical-process","display_name":"Chemical process","score":0.4973647892475128},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.4546227753162384},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.42758461833000183},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3664781451225281},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3496442139148712},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3022317886352539},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2193688452243805},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2015913426876068},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1986669898033142},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.12743887305259705},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.12277144193649292}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6242993474006653},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.6206718683242798},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.593840479850769},{"id":"https://openalex.org/C2776330181","wikidata":"https://www.wikidata.org/wiki/Q18358244","display_name":"Maximization","level":2,"score":0.5110974907875061},{"id":"https://openalex.org/C124223222","wikidata":"https://www.wikidata.org/wiki/Q2281940","display_name":"Chemical process","level":2,"score":0.4973647892475128},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4546227753162384},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.42758461833000183},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3664781451225281},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3496442139148712},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3022317886352539},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2193688452243805},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2015913426876068},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1986669898033142},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.12743887305259705},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.12277144193649292},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1109/ecc.2016.7810556","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ecc.2016.7810556","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2016 European Control Conference (ECC)","raw_type":"proceedings-article"},{"id":"pmh:oai:pure.atira.dk:openaire/3d066dab-41eb-435c-8820-7b90c4ee067a","is_oa":true,"landing_page_url":"https://pureportal.coventry.ac.uk/en/publications/3d066dab-41eb-435c-8820-7b90c4ee067a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402411","display_name":"Pure (Coventry University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I73417466","host_organization_name":"Coventry University","host_organization_lineage":["https://openalex.org/I73417466"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foo, M, Sawlekar, R, Kim, J, Bates, D G, Stan, G B & Kulkarni, V 2017, Biomolecular implementation of nonlinear system theoretic operators. in 2016 European Control Conference, ECC 2016. 2016 European Control Conference, ECC 2016, Institute of Electrical and Electronics Engineers Inc., pp. 1824-1831, 2016 European Control Conference, Aalborg, Denmark, 29/06/16. https://doi.org/10.1109/ECC.2016.7810556","raw_type":"info:eu-repo/semantics/conferenceObject"},{"id":"pmh:oai:wrap.warwick.ac.uk:84213","is_oa":false,"landing_page_url":"http://wrap.warwick.ac.uk/84213/7/WRAP_crn_nonlinear_ecc2016_VVK-March30.pdf","pdf_url":"http://wrap.warwick.ac.uk/84213/7/WRAP_crn_nonlinear_ecc2016_VVK-March30.pdf","source":{"id":"https://openalex.org/S4306400665","display_name":"Warwick Research Archive Portal (University of Warwick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I39555362","host_organization_name":"University of Warwick","host_organization_lineage":["https://openalex.org/I39555362"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Conference Item"},{"id":"pmh:oai:pure.atira.dk:publications/3d066dab-41eb-435c-8820-7b90c4ee067a","is_oa":false,"landing_page_url":"https://pureportal.coventry.ac.uk/en/publications/biomolecular-implementation-of-nonlinear-system-theoretic-operators(3d066dab-41eb-435c-8820-7b90c4ee067a).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402411","display_name":"Pure (Coventry University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I73417466","host_organization_name":"Coventry University","host_organization_lineage":["https://openalex.org/I73417466"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/53630","is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/53630","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Control Conference (ECC)","raw_type":"Conference Paper"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire/3d066dab-41eb-435c-8820-7b90c4ee067a","is_oa":true,"landing_page_url":"https://pureportal.coventry.ac.uk/en/publications/3d066dab-41eb-435c-8820-7b90c4ee067a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402411","display_name":"Pure (Coventry University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I73417466","host_organization_name":"Coventry University","host_organization_lineage":["https://openalex.org/I73417466"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Foo, M, Sawlekar, R, Kim, J, Bates, D G, Stan, G B & Kulkarni, V 2017, Biomolecular implementation of nonlinear system theoretic operators. in 2016 European Control Conference, ECC 2016. 2016 European Control Conference, ECC 2016, Institute of Electrical and Electronics Engineers Inc., pp. 1824-1831, 2016 European Control Conference, Aalborg, Denmark, 29/06/16. https://doi.org/10.1109/ECC.2016.7810556","raw_type":"info:eu-repo/semantics/conferenceObject"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1511075568","display_name":null,"funder_award_id":"EP/M002187/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G1899910","display_name":"Engineering Fellowships for Growth: Systems and control engineering framework for robust and efficient synthetic biology","funder_award_id":"EP/M002187/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G2774327540","display_name":null,"funder_award_id":"EP/M002187","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G3184405124","display_name":null,"funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3293224696","display_name":"Warwick Integrative Synthetic Biology Centre","funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4122777843","display_name":null,"funder_award_id":"BB/M017982","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G625002215","display_name":null,"funder_award_id":"BB/M017982/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320320279","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W75441505","https://openalex.org/W1596194860","https://openalex.org/W1623155147","https://openalex.org/W1645305843","https://openalex.org/W1964928696","https://openalex.org/W1977624796","https://openalex.org/W1990476699","https://openalex.org/W2005615084","https://openalex.org/W2008626444","https://openalex.org/W2008793553","https://openalex.org/W2020376340","https://openalex.org/W2021540900","https://openalex.org/W2023145868","https://openalex.org/W2027576577","https://openalex.org/W2036546758","https://openalex.org/W2049311792","https://openalex.org/W2050630660","https://openalex.org/W2052212572","https://openalex.org/W2081534232","https://openalex.org/W2094781369","https://openalex.org/W2108903561","https://openalex.org/W2110216011","https://openalex.org/W2111843456","https://openalex.org/W2117056464","https://openalex.org/W2134759932","https://openalex.org/W2139771289","https://openalex.org/W2163730983","https://openalex.org/W2295269446","https://openalex.org/W6663079200","https://openalex.org/W6677729657"],"related_works":["https://openalex.org/W3141738981","https://openalex.org/W2099102792","https://openalex.org/W4254255930","https://openalex.org/W2009687716","https://openalex.org/W634364059","https://openalex.org/W4377564965","https://openalex.org/W4205129443","https://openalex.org/W2555186193","https://openalex.org/W2022630293","https://openalex.org/W2794977423"],"abstract_inverted_index":{"Synthesis":[0],"of":[1,12,19,73,111,118,121,133],"biomolecular":[2],"circuits":[3],"for":[4,129],"controlling":[5],"molecular-scale":[6],"processes":[7],"is":[8],"an":[9],"important":[10],"goal":[11],"synthetic":[13],"biology":[14],"with":[15],"a":[16,112,126,134],"wide":[17],"range":[18],"in":[20,23],"vitro":[21],"and":[22,32,64,78,124],"vivo":[24],"applications,":[25],"including":[26],"biomass":[27],"maximization,":[28],"nanoscale":[29],"drug":[30],"delivery,":[31],"many":[33],"others.":[34],"In":[35],"this":[36],"paper,":[37],"we":[38],"present":[39],"new":[40],"results":[41,103],"on":[42],"how":[43,70,90],"abstract":[44],"chemical":[45,92],"reactions":[46,93],"can":[47,80,94],"be":[48,81,95],"used":[49,53],"to":[50,83],"implement":[51,84],"commonly":[52],"system":[54],"theoretic":[55],"operators":[56],"such":[57,91],"as":[58],"the":[59,116,119,131],"polynomial":[60],"functions,":[61],"rational":[62],"functions":[63],"Hill-type":[65],"nonlinearity.":[66],"We":[67,87],"first":[68],"describe":[69],"idealised":[71],"versions":[72],"multi-molecular":[74],"reactions,":[75],"catalysis,":[76],"annihilation,":[77],"degradation":[79],"combined":[82],"these":[85],"operators.":[86],"then":[88],"show":[89],"implemented":[96],"using":[97],"enzyme-free,":[98],"entropy-driven":[99],"DNA":[100],"reactions.":[101],"Our":[102],"are":[104],"illustrated":[105],"through":[106],"three":[107],"applications:":[108],"(1)":[109],"implementation":[110],"Stan-Sepulchre":[113],"oscillator,":[114],"(2)":[115],"computation":[117],"ratio":[120],"two":[122],"signals,":[123],"(3)":[125],"PI+antiwindup":[127],"controller":[128],"regulating":[130],"output":[132],"static":[135],"nonlinear":[136],"plant.":[137]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-08-11T07:18:39.950985","created_date":"2025-10-10T00:00:00"}