{"id":"https://openalex.org/W4401070930","doi":"https://doi.org/10.1109/drc61706.2024.10605396","title":"The nanopore-FET: a nanofluidic-nanoelectronic silicon-based device for enabling proteomics","display_name":"The nanopore-FET: a nanofluidic-nanoelectronic silicon-based device for enabling proteomics","publication_year":2024,"publication_date":"2024-06-24","ids":{"openalex":"https://openalex.org/W4401070930","doi":"https://doi.org/10.1109/drc61706.2024.10605396"},"language":"en","primary_location":{"id":"doi:10.1109/drc61706.2024.10605396","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/drc61706.2024.10605396","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 Device Research Conference (DRC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082568923","display_name":"Anne S. Verhulst","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Anne S. Verhulst","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044665841","display_name":"Aderik Voorspoels","orcid":"https://orcid.org/0000-0003-1955-2254"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Aderik Voorspoels","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071469619","display_name":"Nihat Akkan","orcid":"https://orcid.org/0000-0001-9067-0603"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Nihat Akkan","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063180502","display_name":"Juliette Gevers","orcid":"https://orcid.org/0000-0003-2677-5093"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Juliette Gevers","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063474361","display_name":"Sybren Santermans","orcid":"https://orcid.org/0000-0002-0843-102X"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Sybren Santermans","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050409249","display_name":"Kherim Willems","orcid":"https://orcid.org/0000-0003-1341-1581"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Kherim Willems","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019896972","display_name":"Koen Martens","orcid":"https://orcid.org/0000-0001-7135-5536"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Martens","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014128177","display_name":"Pol Van Dorpe","orcid":"https://orcid.org/0000-0003-0918-1664"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Pol Van Dorpe","raw_affiliation_strings":["imec,Leuven,Belgium,3001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"imec,Leuven,Belgium,3001","institution_ids":["https://openalex.org/I4210114974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210114974"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09853948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11582","display_name":"Nanopore and Nanochannel Transport Studies","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10412","display_name":"Microfluidic and Capillary Electrophoresis Applications","score":0.9739000201225281,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanopore","display_name":"Nanopore","score":0.8070959448814392},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.674474835395813},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.6705926656723022},{"id":"https://openalex.org/keywords/silicon","display_name":"Silicon","score":0.6700398921966553},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.42013996839523315}],"concepts":[{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.8070959448814392},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.674474835395813},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6705926656723022},{"id":"https://openalex.org/C544956773","wikidata":"https://www.wikidata.org/wiki/Q670","display_name":"Silicon","level":2,"score":0.6700398921966553},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.42013996839523315}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/drc61706.2024.10605396","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1109/drc61706.2024.10605396","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2024 Device Research Conference (DRC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W2009886994","https://openalex.org/W2167969083","https://openalex.org/W2562252980","https://openalex.org/W2936223241","https://openalex.org/W4210924530"],"related_works":["https://openalex.org/W2055215578","https://openalex.org/W3097090396","https://openalex.org/W2734703372","https://openalex.org/W2267068863","https://openalex.org/W1989500433","https://openalex.org/W2924313437","https://openalex.org/W2328692626","https://openalex.org/W3141442004","https://openalex.org/W2011288926","https://openalex.org/W2952466397"],"abstract_inverted_index":{"Determining":[0],"the":[1,5,18,26,32,77,97,118,123,126,130,145,149,187,194],"DNA":[2,141],"sequence":[3],"of":[4,35,101,136,148],"human":[6,27],"genome":[7],"not":[8],"only":[9],"transformed":[10],"biology":[11],"but":[12],"also":[13],"revolutionized":[14],"medicine.":[15],"To":[16,155],"make":[17],"next":[19],"step":[20],"towards":[21],"precision":[22],"and":[23,50],"personalized":[24],"medicine,":[25],"proteome":[28],"(":[29],"i.e.":[30],",":[31,92,143,152,181],"complete":[33],"set":[34],"human-produced":[36],"proteins)":[37],"needs":[38],"to":[39,76,140,193],"be":[40],"determined":[41],"as":[42,138,189,191],"well.":[43],"But":[44],"that":[45,63,72,165],"requires":[46],"a":[47,61,110,167,171],"more":[48],"sensitive":[49],"higher":[51],"throughput":[52],"technique":[53,62,85,150],"than":[54],"is":[55,74,86],"available":[56],"today,":[57],"and,":[58],"very":[59,82],"importantly,":[60],"can":[64],"perform":[65],"measurements":[66],"on":[67,88,162],"unaltered,":[68],"single":[69],"proteins,":[70,137],"such":[71],"there":[73],"access":[75],"fundamental":[78],"protein":[79],"properties.":[80],"A":[81],"promising,":[83],"recent":[84],"based":[87],"nanopore":[89,111,124,169],"sensing":[90],"[1":[91],"2]":[93],".":[94,154,183],"In":[95],"essence,":[96],"working":[98],"principle":[99],"consists":[100],"driving":[102],"an":[103,106,163],"analyte":[104],"in":[105],"electrolyte":[107],"solution":[108],"through":[109,122],"between":[112],"2":[113],"reservoirs,":[114],"while":[115],"measuring":[116],"either":[117],"ionic":[119],"current":[120],"variations":[121,128],"or":[125],"voltage":[127],"inside":[129],"nanopore.":[131],"The":[132],"fast":[133],"translocation":[134],"speed":[135],"compared":[139],"e.g.":[142],"prevents":[144],"general":[146],"applicability":[147],"[3":[151],"4]":[153],"overcome":[156],"this":[157],"challenge,":[158],"we":[159],"are":[160],"focusing":[161],"implementation":[164],"embeds":[166],"solid-state":[168],"into":[170],"nanoscale":[172],"field-effect":[173],"transistor":[174],"(nanopore-FET)":[175],"(see":[176],"Fig.":[177],"1":[178],")":[179],"[5":[180],"6]":[182],"This":[184],"approach":[185],"brings":[186],"amplifier":[188],"close":[190],"possible":[192],"nanopore,":[195],"promising":[196],"increased":[197],"bandwidth.":[198]},"counts_by_year":[],"updated_date":"2026-06-26T08:34:08.712188","created_date":"2025-10-10T00:00:00"}