{"id":"https://openalex.org/W2889135846","doi":"https://doi.org/10.1109/drc.2018.8442212","title":"Color-Filtered Si Photodiode Array for On-Chip Calcium Imaging in Living Cells","display_name":"Color-Filtered Si Photodiode Array for On-Chip Calcium Imaging in Living Cells","publication_year":2018,"publication_date":"2018-06-01","ids":{"openalex":"https://openalex.org/W2889135846","doi":"https://doi.org/10.1109/drc.2018.8442212","mag":"2889135846"},"language":"en","primary_location":{"id":"doi:10.1109/drc.2018.8442212","is_oa":false,"landing_page_url":"https://doi.org/10.1109/drc.2018.8442212","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 76th Device Research Conference (DRC)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100683262","display_name":"Zheshun Xiong","orcid":"https://orcid.org/0009-0007-6582-6005"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Z. Xiong","raw_affiliation_strings":["Department of Electrical and Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031664190","display_name":"Fuu-Jiun Hwang","orcid":"https://orcid.org/0000-0003-0477-986X"},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F.-J. Hwang","raw_affiliation_strings":["University of Massachusetts Amherst, Amherst, MA, US"],"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst, Amherst, MA, US","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053026752","display_name":"Dacheng Mao","orcid":"https://orcid.org/0000-0001-6434-8557"},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Mao","raw_affiliation_strings":["Department of Biology, University of Massachusetts, Amherst, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts, Amherst, MA, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057197923","display_name":"Guo\u2010Hua Li","orcid":null},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.-L. Li","raw_affiliation_strings":["University of Massachusetts Amherst, Amherst, MA, US"],"affiliations":[{"raw_affiliation_string":"University of Massachusetts Amherst, Amherst, MA, US","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001878763","display_name":"Guangyu Xu","orcid":"https://orcid.org/0000-0003-1423-5399"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Xu","raw_affiliation_strings":["Department of Electrical and Computer Engineering"],"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100683262"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.107,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41412537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"6","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11240","display_name":"Luminescence and Fluorescent Materials","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fluorescence","display_name":"Fluorescence","score":0.63776695728302},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.48111194372177124},{"id":"https://openalex.org/keywords/photodiode","display_name":"Photodiode","score":0.4787009060382843},{"id":"https://openalex.org/keywords/calcium-imaging","display_name":"Calcium imaging","score":0.4570905566215515},{"id":"https://openalex.org/keywords/calcium","display_name":"Calcium","score":0.4356370270252228},{"id":"https://openalex.org/keywords/fluorescence-microscope","display_name":"Fluorescence microscope","score":0.43216753005981445},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3915584087371826},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3731487989425659},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.34381943941116333},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.33500468730926514},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.29628050327301025},{"id":"https://openalex.org/keywords/optoelectronics","display_name":"Optoelectronics","score":0.277142733335495},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23364317417144775},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1840735375881195},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.17356887459754944},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.103727787733078}],"concepts":[{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.63776695728302},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.48111194372177124},{"id":"https://openalex.org/C751236","wikidata":"https://www.wikidata.org/wiki/Q175943","display_name":"Photodiode","level":2,"score":0.4787009060382843},{"id":"https://openalex.org/C2776032975","wikidata":"https://www.wikidata.org/wiki/Q5018833","display_name":"Calcium imaging","level":3,"score":0.4570905566215515},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4356370270252228},{"id":"https://openalex.org/C169274487","wikidata":"https://www.wikidata.org/wiki/Q840211","display_name":"Fluorescence microscope","level":3,"score":0.43216753005981445},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3915584087371826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3731487989425659},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.34381943941116333},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33500468730926514},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.29628050327301025},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.277142733335495},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23364317417144775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1840735375881195},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.17356887459754944},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.103727787733078},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/drc.2018.8442212","is_oa":false,"landing_page_url":"https://doi.org/10.1109/drc.2018.8442212","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2018 76th Device Research Conference (DRC)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W1970307328","https://openalex.org/W2016399530","https://openalex.org/W2293817841"],"related_works":["https://openalex.org/W1977514416","https://openalex.org/W1508801824","https://openalex.org/W3103825119","https://openalex.org/W2105026576","https://openalex.org/W2033236975","https://openalex.org/W2140280965","https://openalex.org/W2184010844","https://openalex.org/W4255002149","https://openalex.org/W2046378968","https://openalex.org/W3101109513"],"abstract_inverted_index":{"Intracellular":[0],"calcium":[1,16,136,229,266],"dynamics":[2,276],"is":[3,73],"crucial":[4],"in":[5,14,61,89,98,231,277],"understanding":[6],"cell":[7],"activities":[8],"[1].":[9],"To":[10,65],"monitor":[11],"the":[12,49,99,198,213,218,228,235,283,287],"change":[13,60],"intracellular":[15,270],"concentration":[17],"([Ca":[18],"<sup":[19,53,69,177,245,272],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[20,54,70,178,246,273],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2+</sup>":[21,55,71,247,274],"]),":[22],"fluorescent":[23,39,76,106,260],"imaging":[24,72,107,127,137,248,294],"has":[25],"been":[26],"broadly":[27],"used":[28],"for":[29,116,163],"its":[30],"outstanding":[31],"sensitivity":[32],"and":[33,91,119,167],"specificity":[34],"[2].":[35],"This":[36,280],"method":[37],"delivers":[38],"molecules":[40,45],"into":[41],"living":[42],"cells.":[43,279],"These":[44],"specifically":[46],"respond":[47],"to":[48,95,201,211],"binding":[50],"of":[51,197,250,258,286],"Ca":[52,68,244],"ions,":[56],"followed":[57],"by":[58,75,217],"a":[59,113,141,151,157,191,204,238,259],"their":[62,117,164],"fluorescence":[63],"intensity.":[64],"date,":[66],"most":[67],"conducted":[74],"microscopes":[77,85],"that":[78,122,265],"have":[79,92,109],"high":[80],"spatiotemporal":[81],"resolutions.":[82],"However,":[83],"these":[84,103],"are":[86],"usually":[87],"large":[88],"size,":[90],"limited":[93],"access":[94],"cells":[96,233],"deep":[97,125,185,297],"tissue":[100,126,186,298],"[3].":[101],"For":[102],"reasons,":[104],"on-chip":[105,135,292],"systems":[108],"recently":[110],"emerged":[111],"as":[112,203],"viable":[114],"alternative":[115],"miniaturized":[118],"implantable":[120],"nature":[121],"can":[123],"grant":[124],"[4].":[128],"In":[129],"this":[130],"work,":[131],"we":[132,189],"present":[133],"an":[134,291],"platform":[138],"based":[139],"on":[140,195],"20-\u03bcm":[142],"pitched":[143],"passive":[144,158],"Si":[145,159],"photodiode":[146],"(PD)":[147],"array":[148,161,200,253,289],"assembled":[149],"with":[150,237,256,296],"high-performance":[152],"color":[153,205],"filter.":[154],"We":[155],"chose":[156],"PD":[160,199,252,288],"structure":[162],"CMOS":[165],"compatibility":[166],"low-power":[168],"operation":[169],"(sub-":[170],"10":[171],"\u03bcW":[172],"power,":[173],"~":[174],"0.2":[175],"mW/mm":[176],"xmlns:xlink=\"http://www.w3.org/1999/xlink\">2</sup>":[179],"power":[180],"density),":[181],"which":[182,207],"allows":[183],"chronic":[184],"imaging.":[187],"Importantly,":[188],"coated":[190],"light":[192,215,222],"absorber":[193],"layer":[194],"top":[196],"serve":[202],"filter,":[206],"offers":[208],"extinction":[209],"ratio":[210],"reject":[212],"excitation":[214],"provided":[216],"microscope.":[219,261],"The":[220,243],"emission":[221],"(peaked":[223],"at":[224],"~602":[225],"nm)":[226],"from":[227],"indicators":[230],"C2C12":[232],"passes":[234],"filter":[236],">":[239],"76%":[240],"transmission":[241],"coefficient.":[242],"data":[249],"our":[251],"well":[254],"match":[255],"those":[257],"Our":[262],"results":[263],"show":[264],"ionophores":[267],"induce":[268],"heterogeneous":[269],"[Ca":[271],"]":[275],"different":[278],"work":[281],"suggests":[282],"possible":[284],"use":[285],"towards":[290],"live-cell":[293],"system":[295],"access.":[299]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
