{"id":"https://openalex.org/W1988308387","doi":"https://doi.org/10.1109/dicta.2012.6411682","title":"Microscopic Image Segmentation with Two-Level Enhancement of Feature Discriminability","display_name":"Microscopic Image Segmentation with Two-Level Enhancement of Feature Discriminability","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W1988308387","doi":"https://doi.org/10.1109/dicta.2012.6411682","mag":"1988308387"},"language":"en","primary_location":{"id":"doi:10.1109/dicta.2012.6411682","is_oa":false,"landing_page_url":"https://doi.org/10.1109/dicta.2012.6411682","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Conference on Digital Image Computing Techniques and Applications (DICTA)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041567418","display_name":"Yang Song","orcid":"https://orcid.org/0000-0003-1283-1672"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Yang Song","raw_affiliation_strings":["BMIT Research Group, University of Sydney, Australia","BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia"],"affiliations":[{"raw_affiliation_string":"BMIT Research Group, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076697411","display_name":"Weidong Cai","orcid":"https://orcid.org/0000-0003-3706-8896"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Weidong Cai","raw_affiliation_strings":["BMIT Research Group, University of Sydney, Australia","BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia"],"affiliations":[{"raw_affiliation_string":"BMIT Research Group, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068891693","display_name":"Dagan Feng","orcid":"https://orcid.org/0000-0002-3381-214X"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Dagan Feng","raw_affiliation_strings":["BMIT Research Group, University of Sydney, Australia","BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia"],"affiliations":[{"raw_affiliation_string":"BMIT Research Group, University of Sydney, Australia","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"BMIT Res. group, Univ. of Sydney, Sydney, NSW, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041567418"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":null,"apc_paid":null,"fwci":1.7106,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.87628435,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.8111851215362549},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.7146257162094116},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.7016352415084839},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.6399920582771301},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6352789998054504},{"id":"https://openalex.org/keywords/pixel","display_name":"Pixel","score":0.6205843687057495},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.6082309484481812},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.6017907857894897},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5810479521751404},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5527665019035339},{"id":"https://openalex.org/keywords/feature-extraction","display_name":"Feature extraction","score":0.4109340310096741}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.8111851215362549},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.7146257162094116},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.7016352415084839},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6399920582771301},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6352789998054504},{"id":"https://openalex.org/C160633673","wikidata":"https://www.wikidata.org/wiki/Q355198","display_name":"Pixel","level":2,"score":0.6205843687057495},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.6082309484481812},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.6017907857894897},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5810479521751404},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5527665019035339},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.4109340310096741},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/dicta.2012.6411682","is_oa":false,"landing_page_url":"https://doi.org/10.1109/dicta.2012.6411682","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 International Conference on Digital Image Computing Techniques and Applications (DICTA)","raw_type":"proceedings-article"},{"id":"pmh:oai:ira.lib.polyu.edu.hk:10397/37815","is_oa":false,"landing_page_url":"http://hdl.handle.net/10397/37815","pdf_url":null,"source":{"id":"https://openalex.org/S4306400205","display_name":"PolyU Institutional Research Archive (Hong Kong Polytechnic University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I14243506","host_organization_name":"Hong Kong Polytechnic University","host_organization_lineage":["https://openalex.org/I14243506"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Conference Paper"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Reduced inequalities","id":"https://metadata.un.org/sdg/10","score":0.7200000286102295}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W128926205","https://openalex.org/W1508404128","https://openalex.org/W1546683379","https://openalex.org/W1898142672","https://openalex.org/W1980219685","https://openalex.org/W2004686526","https://openalex.org/W2017143576","https://openalex.org/W2098917263","https://openalex.org/W2101309634","https://openalex.org/W2104311408","https://openalex.org/W2116148865","https://openalex.org/W2127183517","https://openalex.org/W2129650255","https://openalex.org/W2132116135","https://openalex.org/W2147880316","https://openalex.org/W2158074918","https://openalex.org/W6630399218","https://openalex.org/W6632643893","https://openalex.org/W6639777894","https://openalex.org/W6682082992"],"related_works":["https://openalex.org/W2965546495","https://openalex.org/W4389116644","https://openalex.org/W2153315159","https://openalex.org/W3103844505","https://openalex.org/W259157601","https://openalex.org/W4205463238","https://openalex.org/W2761785940","https://openalex.org/W1482209366","https://openalex.org/W2110523656","https://openalex.org/W1617617605"],"abstract_inverted_index":{"Microscopic":[0],"cellular":[1],"image":[2],"segmentation":[3,18],"has":[4],"become":[5],"one":[6],"of":[7,32,94,129],"the":[8,80,91,105,117,139],"most":[9],"important":[10],"routine":[11],"procedures":[12],"in":[13],"modern":[14],"biological":[15],"applications.":[16],"The":[17,120],"task":[19],"is":[20,87,123],"non-trivial,":[21],"however,":[22],"mainly":[23],"due":[24],"to":[25,62,89],"imaging":[26],"artifacts":[27],"causing":[28],"highly":[29],"inhomogeneous":[30],"appearances":[31],"cell":[33,54,74],"nuclei":[34,55],"and":[35,42,56,59,108,134],"background":[36,57],"with":[37],"large":[38],"intensity":[39,81,95,101],"variations":[40],"within":[41],"across":[43],"images.":[44],"Such":[45],"inconsistent":[46],"appearance":[47],"profiles":[48],"would":[49],"cause":[50],"feature":[51],"overlapping":[52],"between":[53],"pixels":[58],"hence":[60],"lead":[61],"misclassifiation.":[63],"In":[64],"this":[65],"paper,":[66],"we":[67],"present":[68],"a":[69,99,110],"novel":[70],"method":[71,122],"for":[72,103,115],"automatic":[73],"nucleus":[75],"segmentation,":[76],"focusing":[77],"on":[78,125],"tackling":[79],"inhomogeneity":[82],"issue.":[83],"A":[84],"two-level":[85],"approach":[86],"designed":[88],"enhance":[90],"discriminative":[92],"power":[93],"features,":[96],"by":[97],"first":[98],"reference-based":[100],"normalization":[102],"reducing":[104],"inter-image":[106],"variations,":[107],"then":[109],"further":[111],"localized":[112],"object":[113],"discrimination":[114],"overcoming":[116],"intra-image":[118],"variations.":[119],"proposed":[121],"evaluated":[124],"three":[126],"different":[127],"sets":[128],"2D":[130],"fluorescence":[131],"microscopy":[132],"images,":[133],"encouraging":[135],"performance":[136],"improvements":[137],"over":[138],"state-of-the-art":[140],"results":[141],"are":[142],"obtained.":[143]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}