{"id":"https://openalex.org/W4214876720","doi":"https://doi.org/10.1109/dese54285.2021.9719384","title":"Identifying Diagnostic and Prognostic Targets for Papillary Thyroid Carcinoma Through Mining Gene Expression BIG Datasets Using Adaptive Filtering and Advanced Bioinformatics Algorithms","display_name":"Identifying Diagnostic and Prognostic Targets for Papillary Thyroid Carcinoma Through Mining Gene Expression BIG Datasets Using Adaptive Filtering and Advanced Bioinformatics Algorithms","publication_year":2021,"publication_date":"2021-12-07","ids":{"openalex":"https://openalex.org/W4214876720","doi":"https://doi.org/10.1109/dese54285.2021.9719384"},"language":"en","primary_location":{"id":"doi:10.1109/dese54285.2021.9719384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/dese54285.2021.9719384","pdf_url":null,"source":{"id":"https://openalex.org/S4363608546","display_name":"2021 14th International Conference on Developments in eSystems Engineering (DeSE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 14th International Conference on Developments in eSystems Engineering (DeSE)","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://discovery.ucl.ac.uk/10154293/2/Hamoudi_Identifying%20Diagnostic%20and%20Prognostic%20targets%20for%20Papillary%20Thyroid%20Carcinoma%20through%20mining%20Gene%20Expression%20BIG%20Datasets%20using%20Adaptive%20Filtering%20and%20Advanced%20Bioinformatics%20Algorithms_AAM.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078782434","display_name":"Asma Almansoori","orcid":null},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Asma Almansoori","raw_affiliation_strings":["Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009153493","display_name":"Poorna Manasa Bhamidimarri","orcid":"https://orcid.org/0000-0002-7418-0492"},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Poorna Manasa Bhamidimarri","raw_affiliation_strings":["Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038257377","display_name":"Riyad Bendardaf","orcid":"https://orcid.org/0000-0002-5158-4590"},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]}],"countries":["AE"],"is_corresponding":false,"raw_author_name":"Riyad Bendardaf","raw_affiliation_strings":["College of Medicine, University of Sharjah,Sharjah,United Arab Emirates,27272","Department of Oncology, University Hospital Sharjah, Sharjah, United Arab Emirates"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Medicine, University of Sharjah,Sharjah,United Arab Emirates,27272","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Department of Oncology, University Hospital Sharjah, Sharjah, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046629044","display_name":"Rifat Hamoudi","orcid":"https://orcid.org/0000-0002-1402-0868"},"institutions":[{"id":"https://openalex.org/I29891158","display_name":"University of Sharjah","ror":"https://ror.org/00engpz63","country_code":"AE","type":"education","lineage":["https://openalex.org/I29891158"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["AE","GB"],"is_corresponding":false,"raw_author_name":"Rifat Hamoudi","raw_affiliation_strings":["Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272","College of Medicine, University of Sharjah, Sharjah, United Arab Emirates","Division of Surgery and Interventional Science, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sharjah Institute for Medical Research, University of Sharjah,Sharjah,United Arab Emirates,27272","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"College of Medicine, University of Sharjah, Sharjah, United Arab Emirates","institution_ids":["https://openalex.org/I29891158"]},{"raw_affiliation_string":"Division of Surgery and Interventional Science, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"102","issue":null,"first_page":"358","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.946399986743927,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-carcinoma","display_name":"Thyroid carcinoma","score":0.6681807637214661},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"Thyroid cancer","score":0.5772314667701721},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.511340320110321},{"id":"https://openalex.org/keywords/papillary-thyroid-cancer","display_name":"Papillary thyroid cancer","score":0.4856363832950592},{"id":"https://openalex.org/keywords/thyroid","display_name":"Thyroid","score":0.4844801127910614},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.4828806221485138},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39803874492645264},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33500105142593384},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3275515139102936},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.26509958505630493},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.20806357264518738}],"concepts":[{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6681807637214661},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5772314667701721},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.511340320110321},{"id":"https://openalex.org/C2781461381","wikidata":"https://www.wikidata.org/wiki/Q2292945","display_name":"Papillary thyroid cancer","level":4,"score":0.4856363832950592},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.4844801127910614},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4828806221485138},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39803874492645264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33500105142593384},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3275515139102936},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26509958505630493},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.20806357264518738}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1109/dese54285.2021.9719384","is_oa":false,"landing_page_url":"https://doi.org/10.1109/dese54285.2021.9719384","pdf_url":null,"source":{"id":"https://openalex.org/S4363608546","display_name":"2021 14th International Conference on Developments in eSystems Engineering (DeSE)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2021 14th International Conference on Developments in eSystems Engineering (DeSE)","raw_type":"proceedings-article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10154293","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10154293/","pdf_url":"https://discovery.ucl.ac.uk/10154293/2/Hamoudi_Identifying%20Diagnostic%20and%20Prognostic%20targets%20for%20Papillary%20Thyroid%20Carcinoma%20through%20mining%20Gene%20Expression%20BIG%20Datasets%20using%20Adaptive%20Filtering%20and%20Advanced%20Bioinformatics%20Algorithms_AAM.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: Proceedings of the14th International Conference on Developments in eSystems Engineering (DeSE) 2021. (pp. pp. 358-363). Institute of Electrical and Electronics Engineers (IEEE) (2021)","raw_type":"Proceedings paper"}],"best_oa_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10154293","is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10154293/","pdf_url":"https://discovery.ucl.ac.uk/10154293/2/Hamoudi_Identifying%20Diagnostic%20and%20Prognostic%20targets%20for%20Papillary%20Thyroid%20Carcinoma%20through%20mining%20Gene%20Expression%20BIG%20Datasets%20using%20Adaptive%20Filtering%20and%20Advanced%20Bioinformatics%20Algorithms_AAM.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: Proceedings of the14th International Conference on Developments in eSystems Engineering (DeSE) 2021. (pp. pp. 358-363). Institute of Electrical and Electronics Engineers (IEEE) (2021)","raw_type":"Proceedings paper"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4214876720.pdf"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W1594389219","https://openalex.org/W1967440935","https://openalex.org/W1977258127","https://openalex.org/W1990762111","https://openalex.org/W2018896819","https://openalex.org/W2020852864","https://openalex.org/W2061341378","https://openalex.org/W2069792474","https://openalex.org/W2103017472","https://openalex.org/W2110214424","https://openalex.org/W2130410032","https://openalex.org/W2171328556","https://openalex.org/W2346266753","https://openalex.org/W2885548039","https://openalex.org/W2900044275","https://openalex.org/W2928665623","https://openalex.org/W2969476850","https://openalex.org/W3004947966","https://openalex.org/W3135402673","https://openalex.org/W3185354749","https://openalex.org/W4233489284"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W3022228189","https://openalex.org/W4389691350","https://openalex.org/W2017000262","https://openalex.org/W2116565214","https://openalex.org/W2520425266","https://openalex.org/W4206801750","https://openalex.org/W2067336395","https://openalex.org/W3211845144","https://openalex.org/W2015018111"],"abstract_inverted_index":{"Thyroid":[0,52],"Cancer":[1],"is":[2,15,28,39,54],"the":[3,9,21,26,61,102,113,125,130,151,158,162,250],"most":[4,33,246],"common":[5,34],"endocrine":[6],"malignancy.":[7],"Although":[8],"mortality":[10],"rate":[11],"of":[12,25,36,44,46,49,63,78,104,124,161,172,235,240,285,294],"thyroid":[13,37,41,50,84,181],"cancer":[14,38,53],"considered":[16,30],"to":[17,74,100,119,149,198,282],"be":[18],"low,":[19],"however":[20],"reoccurrence":[22],"and":[23,56,177,192,209,220,238,258,263,267,279],"persistence":[24],"disease":[27,115],"still":[29],"high.":[31],"The":[32,201,225,245,288],"type":[35],"papillary":[40,83,180],"carcinoma":[42,85,182],"consisting":[43,171],">70%":[45],"all":[47],"types":[48],"cancer.":[51],"heterogeneous":[55],"complex.":[57],"BIG":[58],"data":[59],"in":[60,128,135],"form":[62],"publicly":[64],"available":[65],"gene":[66],"expression":[67],"(transcriptomics)":[68],"datasets":[69],"can":[70],"provide":[71],"valuable":[72],"source":[73],"gain":[75],"deeper":[76],"understanding":[77],"complex":[79],"diseases":[80],"such":[81],"as":[82],"(PTC).":[86],"In":[87,117],"this":[88],"study,":[89],"we":[90],"used":[91,134],"a":[92],"novel":[93],"bioinformatics":[94],"method":[95],"based":[96],"on":[97,122],"adaptive":[98],"filtering":[99],"reduce":[101],"number":[103],"genes":[105,108,132,248],"expressed":[106],"eliminating":[107],"that":[109,276],"are":[110],"invariant":[111],"across":[112,140,157,249],"various":[114,159],"stages.":[116],"order":[118],"shed":[120],"light":[121],"some":[123],"mechanisms":[126,293],"involved":[127],"PTC,":[129,262],"filtered":[131],"were":[133,253],"systematic":[136],"pathway":[137],"analysis":[138,165,273],"searches":[139],"20,500":[141],"annotated":[142],"cellular":[143,155,187],"pathways":[144,156,188,203,227,252],"using":[145],"modified":[146],"Kolmogorov-Smirnov":[147],"algorithm":[148],"identify":[150],"relevant":[152],"differentially":[153],"activated":[154,186],"stages":[160],"disease.":[163],"Our":[164],"from":[166],"95":[167],"PTC":[168,206,230,286],"patient":[169],"biopsies":[170],"41":[173],"normal,":[174],"28":[175],"non-aggressive":[176,190,205,261],"26":[178],"metastatic":[179,195,229,270],"revealed":[183],"2193":[184],"differential":[185],"among":[189,194],"samples":[191,196],"1969":[193],"compared":[197],"normal":[199],"tissue.":[200],"key":[202,226],"for":[204,228,260,269],"includes":[207],"calcium":[208],"potassium":[210],"ion":[211],"transport,":[212],"hormone":[213],"signaling":[214],"pathways,":[215],"protein":[216,221],"tyrosine":[217,222],"phosphatase":[218],"activity":[219,237],"kinase":[223,243],"activity.":[224,244],"include":[231],"growth,":[232],"apoptosis,":[233],"activation":[234],"MAPK":[236],"regulation":[239],"serine":[241],"threonine":[242],"frequent":[247],"enriched":[251],"KCNQ1,":[254],"CACNA1D,":[255],"KCNN4,":[256],"BCL2,":[257],"PTK2B":[259],"EGFR,":[264],"PTK2B,":[265,277],"KCNN4":[266],"BCL2":[268,280],"PTC.":[271,295],"Survival":[272],"results":[274],"showed":[275],"CACNA1D":[278],"contributed":[281],"poor":[283],"survival":[284],"patients.":[287],"study":[289],"identified":[290],"insights":[291],"into":[292]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-07-28T07:46:37.118299","created_date":"2025-10-10T00:00:00"}