{"id":"https://openalex.org/W3148034496","doi":"https://doi.org/10.1109/date.2012.6176469","title":"Genetic/bio design automation for (re-)engineering biological systems","display_name":"Genetic/bio design automation for (re-)engineering biological systems","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W3148034496","doi":"https://doi.org/10.1109/date.2012.6176469","mag":"3148034496"},"language":"en","primary_location":{"id":"doi:10.1109/date.2012.6176469","is_oa":false,"landing_page_url":"https://doi.org/10.1109/date.2012.6176469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Design, Automation & Test in Europe Conference & Exhibition (DATE)","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048817284","display_name":"Soha Hassoun","orcid":"https://orcid.org/0000-0001-9477-2199"},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. Hassoun","raw_affiliation_strings":["Department of Computer Science, Tufts University, Medford, MA, USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, Tufts University, Medford, MA, USA","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048817284"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":null,"apc_paid":null,"fwci":0.2627,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.59367361,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3","issue":null,"first_page":"242","last_page":"247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9819999933242798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/automation","display_name":"Automation","score":0.6678406596183777},{"id":"https://openalex.org/keywords/computer-automated-design","display_name":"Computer-automated design","score":0.6409576535224915},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5486347675323486},{"id":"https://openalex.org/keywords/electronic-design-automation","display_name":"Electronic design automation","score":0.47906097769737244},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.4651763141155243},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.3367560803890228},{"id":"https://openalex.org/keywords/systems-design","display_name":"Systems design","score":0.2982240617275238},{"id":"https://openalex.org/keywords/software-engineering","display_name":"Software engineering","score":0.2887870669364929},{"id":"https://openalex.org/keywords/embedded-system","display_name":"Embedded system","score":0.15425574779510498},{"id":"https://openalex.org/keywords/mechanical-engineering","display_name":"Mechanical engineering","score":0.13561102747917175}],"concepts":[{"id":"https://openalex.org/C115901376","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automation","level":2,"score":0.6678406596183777},{"id":"https://openalex.org/C205976826","wikidata":"https://www.wikidata.org/wiki/Q5157390","display_name":"Computer-automated design","level":3,"score":0.6409576535224915},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5486347675323486},{"id":"https://openalex.org/C64260653","wikidata":"https://www.wikidata.org/wiki/Q1194864","display_name":"Electronic design automation","level":2,"score":0.47906097769737244},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.4651763141155243},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.3367560803890228},{"id":"https://openalex.org/C31352089","wikidata":"https://www.wikidata.org/wiki/Q3750474","display_name":"Systems design","level":2,"score":0.2982240617275238},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.2887870669364929},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.15425574779510498},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.13561102747917175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/date.2012.6176469","is_oa":false,"landing_page_url":"https://doi.org/10.1109/date.2012.6176469","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2012 Design, Automation & Test in Europe Conference & Exhibition (DATE)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W35463602","https://openalex.org/W1543833632","https://openalex.org/W1549936579","https://openalex.org/W1579292960","https://openalex.org/W1592132377","https://openalex.org/W1970556744","https://openalex.org/W1981779283","https://openalex.org/W1982836457","https://openalex.org/W1987607959","https://openalex.org/W1989543002","https://openalex.org/W1994134392","https://openalex.org/W1996529795","https://openalex.org/W1997996256","https://openalex.org/W2002560900","https://openalex.org/W2003000734","https://openalex.org/W2006943154","https://openalex.org/W2028343312","https://openalex.org/W2031785499","https://openalex.org/W2032408161","https://openalex.org/W2042067428","https://openalex.org/W2055799844","https://openalex.org/W2062819025","https://openalex.org/W2065432632","https://openalex.org/W2066614304","https://openalex.org/W2073293499","https://openalex.org/W2083011190","https://openalex.org/W2085993965","https://openalex.org/W2100084634","https://openalex.org/W2102164505","https://openalex.org/W2107409961","https://openalex.org/W2108590631","https://openalex.org/W2113983551","https://openalex.org/W2116324021","https://openalex.org/W2122436512","https://openalex.org/W2128746754","https://openalex.org/W2129106849","https://openalex.org/W2132207273","https://openalex.org/W2135206190","https://openalex.org/W2144779133","https://openalex.org/W2160237938","https://openalex.org/W2165603655","https://openalex.org/W2166927282","https://openalex.org/W2167330628","https://openalex.org/W2180208126","https://openalex.org/W6645665922","https://openalex.org/W6647502407"],"related_works":["https://openalex.org/W1965052231","https://openalex.org/W3206090678","https://openalex.org/W2116146778","https://openalex.org/W3023070634","https://openalex.org/W2015574931","https://openalex.org/W2759881596","https://openalex.org/W2888160777","https://openalex.org/W2542536804","https://openalex.org/W2050767015","https://openalex.org/W2074925005"],"abstract_inverted_index":{"Constructing":[0],"biological":[1,31,59,94],"circuits":[2],"in":[3,15,21,38,45,63,84],"a":[4],"bottom-up":[5],"modular":[6],"fashion":[7],"using":[8],"design":[9,61,88],"methodologies":[10,91],"similar":[11],"to":[12],"those":[13],"used":[14],"electronics":[16],"has":[17],"gained":[18],"tremendous":[19],"attention":[20],"the":[22,39,51,56],"past":[23],"decade.":[24],"The":[25],"end":[26],"goal,":[27],"however,":[28],"is":[29],"engineering":[30,93],"systems":[32],"and":[33,66,69,76,90],"not":[34],"only":[35],"individual":[36],"components":[37],"context":[40],"of":[41,58],"pursuing":[42],"applications":[43],"useful":[44],"improving":[46],"human":[47],"health":[48],"or":[49],"enhancing":[50],"environment.":[52],"This":[53],"article":[54],"reviews":[55],"basics":[57],"system":[60],"rooted":[62],"Metabolic":[64],"Engineering":[65],"Systems":[67],"Biology":[68],"outlines":[70],"current":[71,82],"system-level":[72],"modeling,":[73],"analysis,":[74],"optimization,":[75],"synthesis":[77],"with":[78],"emphasis":[79],"on":[80],"some":[81],"bottlenecks":[83],"establishing":[85],"more":[86],"rigorous":[87],"tools":[89],"for":[92],"systems.":[95]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}