{"id":"https://openalex.org/W2137558998","doi":"https://doi.org/10.1109/cvprw.2009.5204057","title":"Tracking of cell populations to understand their spatio-temporal behavior in response to physical stimuli","display_name":"Tracking of cell populations to understand their spatio-temporal behavior in response to physical stimuli","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W2137558998","doi":"https://doi.org/10.1109/cvprw.2009.5204057","mag":"2137558998"},"language":"en","primary_location":{"id":"doi:10.1109/cvprw.2009.5204057","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cvprw.2009.5204057","pdf_url":null,"source":{"id":"https://openalex.org/S4363608118","display_name":"2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108167329","display_name":"David House","orcid":"https://orcid.org/0000-0002-4628-3769"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David House","raw_affiliation_strings":["Departments of Computer Science, Boston University, USA","Department of Computer Science Boston University Boston MA USA"],"affiliations":[{"raw_affiliation_string":"Departments of Computer Science, Boston University, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Computer Science Boston University Boston MA USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104034282","display_name":"Matthew L. Walker","orcid":null},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew L. Walker","raw_affiliation_strings":["Biomedical Engineering, Boston University, USA","Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Boston University, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101409712","display_name":"Zheng Wu","orcid":"https://orcid.org/0000-0003-4207-3657"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zheng Wu","raw_affiliation_strings":["Departments of Computer Engineering Science, Boston University, USA","Department of Computer Science Boston University Boston MA USA"],"affiliations":[{"raw_affiliation_string":"Departments of Computer Engineering Science, Boston University, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Computer Science Boston University Boston MA USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034776394","display_name":"Joyce Wong","orcid":"https://orcid.org/0000-0002-3526-6381"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyce Y. Wong","raw_affiliation_strings":["Biomedical Engineering, Boston University, USA","Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering, Boston University, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Dept. of Biomed. Eng., Boston Univ., Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058798782","display_name":"Margrit Betke","orcid":"https://orcid.org/0000-0002-4491-6868"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margrit Betke","raw_affiliation_strings":["Departments of Computer Science, Boston University, USA","Department of Computer Science Boston University Boston MA USA"],"affiliations":[{"raw_affiliation_string":"Departments of Computer Science, Boston University, USA","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Computer Science Boston University Boston MA USA","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5108167329"],"corresponding_institution_ids":["https://openalex.org/I111088046"],"apc_list":null,"apc_paid":null,"fwci":15.8621,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"186","last_page":"193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clutter","display_name":"Clutter","score":0.6581078767776489},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.5733509063720703},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5344658493995667},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.4898907542228699},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.46007877588272095},{"id":"https://openalex.org/keywords/multicellular-organism","display_name":"Multicellular organism","score":0.4575177729129791},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4522557258605957},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.42914384603500366},{"id":"https://openalex.org/keywords/random-walk","display_name":"Random walk","score":0.4251704812049866},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.39688193798065186},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.3761425316333771},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.34825414419174194},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2179017961025238},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1859324872493744},{"id":"https://openalex.org/keywords/radar","display_name":"Radar","score":0.10917207598686218}],"concepts":[{"id":"https://openalex.org/C132094186","wikidata":"https://www.wikidata.org/wiki/Q641585","display_name":"Clutter","level":3,"score":0.6581078767776489},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.5733509063720703},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5344658493995667},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.4898907542228699},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.46007877588272095},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.4575177729129791},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4522557258605957},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.42914384603500366},{"id":"https://openalex.org/C121194460","wikidata":"https://www.wikidata.org/wiki/Q856741","display_name":"Random walk","level":2,"score":0.4251704812049866},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.39688193798065186},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3761425316333771},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.34825414419174194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2179017961025238},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1859324872493744},{"id":"https://openalex.org/C554190296","wikidata":"https://www.wikidata.org/wiki/Q47528","display_name":"Radar","level":2,"score":0.10917207598686218},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1109/cvprw.2009.5204057","is_oa":false,"landing_page_url":"https://doi.org/10.1109/cvprw.2009.5204057","pdf_url":null,"source":{"id":"https://openalex.org/S4363608118","display_name":"2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2009 IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops","raw_type":"proceedings-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.158.2796","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.158.2796","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.bu.edu/fac/betke/papers/House-etal-MMBIA-2009.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.224.3024","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.224.3024","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cs-people.bu.edu/wuzheng/research/publication/MMBIA2009.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.459.2766","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.459.2766","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://csr.bu.edu/cells/content/house-etal.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.75}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W635669621","https://openalex.org/W1542184883","https://openalex.org/W1593910109","https://openalex.org/W1970613379","https://openalex.org/W1984724534","https://openalex.org/W1989493360","https://openalex.org/W2023667918","https://openalex.org/W2024250498","https://openalex.org/W2044973895","https://openalex.org/W2093872708","https://openalex.org/W2103247257","https://openalex.org/W2115283652","https://openalex.org/W2118688758","https://openalex.org/W2119345721","https://openalex.org/W2128871431","https://openalex.org/W2129078811","https://openalex.org/W2140181136","https://openalex.org/W2143871084","https://openalex.org/W2146688665","https://openalex.org/W2151705331","https://openalex.org/W2159001825","https://openalex.org/W2161841955","https://openalex.org/W2162170877","https://openalex.org/W2409220685","https://openalex.org/W2911709767","https://openalex.org/W3089669417","https://openalex.org/W6676887477"],"related_works":["https://openalex.org/W1963836821","https://openalex.org/W2522472446","https://openalex.org/W2145740829","https://openalex.org/W4281994149","https://openalex.org/W345142232","https://openalex.org/W2166797439","https://openalex.org/W2805325890","https://openalex.org/W4247350725","https://openalex.org/W2132267912","https://openalex.org/W2038227545"],"abstract_inverted_index":{"We":[0,63,91],"have":[1],"developed":[2],"methods":[3],"for":[4,105],"segmentation":[5],"and":[6,20,30,57,75,78],"tracking":[7],"of":[8,24,28,42,82,110,115,117,128],"cells":[9,25,130],"in":[10,26,102,124,133],"time-lapse":[11],"phase-contrast":[12],"microscopy":[13],"images.":[14],"Our":[15,113],"multi-object":[16],"Bayesian":[17],"algorithm":[18],"detects":[19],"tracks":[21],"large":[22],"numbers":[23],"presence":[27],"clutter":[29],"identifies":[31],"cell":[32,46,69,83,94,119],"division.":[33],"To":[34],"solve":[35],"the":[36,40,86,98,103,107,111,125],"data":[37],"association":[38],"problem,":[39],"assignment":[41,61],"current":[43],"measurements":[44],"to":[45,67,97,131],"tracks,":[47],"we":[48],"tested":[49],"various":[50],"cost":[51],"functions":[52],"with":[53,85],"both":[54],"an":[55],"optimal":[56],"a":[58],"fast,":[59],"suboptimal":[60],"algorithm.":[62],"also":[64],"propose":[65],"metrics":[66],"quantify":[68],"migration":[70,84],"properties,":[71],"such":[72],"as":[73],"motility":[74],"directional":[76],"persistence,":[77],"compared":[79],"our":[80],"findings":[81],"standard":[87],"random":[88],"walk":[89],"model.":[90],"measured":[92],"how":[93],"populations":[95],"respond":[96],"physical":[99],"stimuli":[100],"presented":[101],"environment,":[104],"example,":[106],"stiffness":[108],"property":[109],"substrate.":[112],"analysis":[114],"hundreds":[116],"spatio-temporal":[118],"trajectories":[120],"revealed":[121],"significant":[122],"differences":[123],"behavioral":[126],"response":[127],"fibroblast":[129],"changes":[132],"hydrogel":[134],"conditions.":[135]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}